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IPR017969

Source: InterPro

Description

IPR017969 is a Heavy-metal-associated, conserved site.

<p>Proteins that transport heavy metals in micro-organisms and mammals share similarities in their sequences and structures.</p> <p>These proteins provide an important focus for research, some being involved in bacterial resistance to toxic metals, such as lead and cadmium, while others are involved in inherited human syndromes, such as Wilson's and Menke's diseases [[cite:PUB00005528]].</p> <p>A conserved domain has been found in a number of these heavy metal transport or detoxification proteins [[cite:PUB00005528]]. The domain, which has been termed Heavy-Metal-Associated (HMA), contains two conserved cysteines that are probably involved in metal binding.</p> <p>Structure solution of the fourth HMA domain of the Menke's copper transporting ATPase shows a well-defined structure comprising a four-stranded antiparallel β-sheet and two α-helices packed in an α-β sandwich fold [[cite:PUB00007951]]. This fold is common to other domains and is classified as "ferredoxin-like".</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0030001
Biological process Metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Subterm of
GO:0046872
Molecular function Metal ion binding Interacting selectively and non-covalently with any metal ion.
Subterm of

Associated Lotus transcripts 17

Transcript Name Description Predicted domains Domain count
Lj0g3v0126429.1
– PREDICTED: copper-transporting ATPase RAN1-like isoform X1 [Cicer arietinum] gi|502141829|ref|XP_004504659.1|
Domains
21
Lj1g3v1091080.2
– PREDICTED: myb-like protein X-like [Cicer arietinum] gi|502095842|ref|XP_004490551.1|
Domains
11
Lj2g3v2017620.1
– Heavy metal P-type ATPase [Medicago truncatula] gi|357518503|ref|XP_003629540.1|
Domains
35
Lj3g3v0718340.1
– Heavy metal ATPase [Medicago truncatula] gi|357513319|ref|XP_003626948.1|
Domains
35
Lj4g3v0341080.1
– PREDICTED: copper-transporting ATPase PAA1, chloroplastic-like [Cicer arietinum] gi|502142103|ref|XP_004504792.1|
Domains
34
Lj4g3v0341080.2
– PREDICTED: copper-transporting ATPase PAA1, chloroplastic-like [Cicer arietinum] gi|502142103|ref|XP_004504792.1|
Domains
10
LotjaGi1g1v0300800.2
– Heavy metal-associated protein; TAIR: AT5G24580.1 Heavy metal transport/detoxification superfamily protein; Swiss-Prot: sp|Q9FLU5|HIP9_ARATH Heavy metal-associated isoprenylated plant protein 9; TrEMBL-Plants: tr|A0A1J7GUW0|A0A1J7GUW0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0300800
Domains
11
LotjaGi2g1v0433300.1
– Copper-transporting ATPase; TAIR: AT1G63440.1 heavy metal atpase 5; Swiss-Prot: sp|Q9SH30|HMA5_ARATH Probable copper-transporting ATPase HMA5; TrEMBL-Plants: tr|G7KDC8|G7KDC8_MEDTR Heavy metal P-type ATPase; Found in the gene: LotjaGi2g1v0433300
Domains
42
LotjaGi2g1v0433500.1
– Copper-transporting ATPase; TAIR: AT1G63440.1 heavy metal atpase 5; Swiss-Prot: sp|Q9SH30|HMA5_ARATH Probable copper-transporting ATPase HMA5; TrEMBL-Plants: tr|A0A1J7G3K0|A0A1J7G3K0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0433500
Domains
41
LotjaGi3g1v0088800.3
– Copper-transporting ATPase; TAIR: AT1G63440.1 heavy metal atpase 5; Swiss-Prot: sp|Q9SH30|HMA5_ARATH Probable copper-transporting ATPase HMA5; TrEMBL-Plants: tr|G7LF66|G7LF66_MEDTR Heavy metal P-type ATPase; Found in the gene: LotjaGi3g1v0088800
Domains
42
LotjaGi3g1v0493500.1
– Copper-transporting ATPase; TAIR: AT1G63440.1 heavy metal atpase 5; Swiss-Prot: sp|Q9SH30|HMA5_ARATH Probable copper-transporting ATPase HMA5; TrEMBL-Plants: tr|A0A0B2SKR1|A0A0B2SKR1_GLYSO Putative copper-transporting ATPase 3; Found in the gene: LotjaGi3g1v0493500
Domains
39
LotjaGi4g1v0020900.1
– Copper-transporting ATPase; TAIR: AT5G44790.1 copper-exporting ATPase / responsive-to-antagonist 1 / copper-transporting ATPase (RAN1); Swiss-Prot: sp|Q9S7J8|HMA7_ARATH Copper-transporting ATPase RAN1; TrEMBL-Plants: tr|A0A072V003|A0A072V003_MEDTR Heavy metal P-type ATPase; Found in the gene: LotjaGi4g1v0020900
Domains
41
LotjaGi4g1v0020900.2
– Copper-transporting ATPase; TAIR: AT5G44790.1 copper-exporting ATPase / responsive-to-antagonist 1 / copper-transporting ATPase (RAN1); Swiss-Prot: sp|Q9S7J8|HMA7_ARATH Copper-transporting ATPase RAN1; TrEMBL-Plants: tr|A0A072V003|A0A072V003_MEDTR Heavy metal P-type ATPase; Found in the gene: LotjaGi4g1v0020900
Domains
41
LotjaGi4g1v0034800.2
– Copper-transporting ATPase; TAIR: AT4G33520.2 P-type ATP-ase 1; Swiss-Prot: sp|Q9SZC9|HMA6_ARATH Copper-transporting ATPase PAA1, chloroplastic; TrEMBL-Plants: tr|I1KR29|I1KR29_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0034800
Domains
42
LotjaGi6g1v0243100.1
– Copper-transporting ATPase; TAIR: AT5G44790.1 copper-exporting ATPase / responsive-to-antagonist 1 / copper-transporting ATPase (RAN1); Swiss-Prot: sp|Q9S7J8|HMA7_ARATH Copper-transporting ATPase RAN1; TrEMBL-Plants: tr|A0A151T5L3|A0A151T5L3_CAJCA Copper-transporting ATPase RAN1; Found in the gene: LotjaGi6g1v0243100
Domains
42
LotjaGi6g1v0243100.2
– Copper-transporting ATPase; TAIR: AT5G44790.1 copper-exporting ATPase / responsive-to-antagonist 1 / copper-transporting ATPase (RAN1); Swiss-Prot: sp|Q9S7J8|HMA7_ARATH Copper-transporting ATPase RAN1; TrEMBL-Plants: tr|A0A151T5L3|A0A151T5L3_CAJCA Copper-transporting ATPase RAN1; Found in the gene: LotjaGi6g1v0243100
Domains
42
LotjaGi6g1v0352800.1
– Copper-transporting atpase p-type, putative; TAIR: AT4G33520.1 P-type ATP-ase 1; Swiss-Prot: sp|Q9SZC9|HMA6_ARATH Copper-transporting ATPase PAA1, chloroplastic; TrEMBL-Plants: tr|V7BQY9|V7BQY9_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0352800
Domains
12

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd00371 CDD 1 5.88