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IPR019580 is a Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding.
<p>This entry represents the interacting site for U6-snRNA, which is part of U4/U6.</p> <p>U5 tri-snRNPs complex of the spliceosome is a prime candidate for the role of cofactor in the spliceosome's RNA core. The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis. This close association with crucial RNA sequences, together with extensive genetic evidence, suggests that Prp8 could directly affect the function of the catalytic core, perhaps acting as a splicing cofactor [[cite:PUB00044474]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | U6 snRNA binding | Interacting selectively and non-covalently with the U6 small nuclear RNA (U6 snRNA). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: pre-mRNA-processing-splicing factor 8-like [Cicer arietinum] gi|502080722|ref|XP_004486659.1| | 21 | ||
| – | Pre-mRNA-processing-splicing factor 8; TAIR: AT1G80070.1 Pre-mRNA-processing-splicing factor; Swiss-Prot: sp|Q9SSD2|PRP8A_ARATH Pre-mRNA-processing-splicing factor 8A; TrEMBL-Plants: tr|V7BXW4|V7BXW4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0008200 | 36 | ||
| – | Pre-mRNA-processing-splicing factor 8; TAIR: AT1G80070.1 Pre-mRNA-processing-splicing factor; Swiss-Prot: sp|Q9SSD2|PRP8A_ARATH Pre-mRNA-processing-splicing factor 8A; TrEMBL-Plants: tr|V7BXW4|V7BXW4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0008200 | 35 | ||
| – | Pre-mRNA-processing-splicing factor 8; TAIR: AT1G80070.1 Pre-mRNA-processing-splicing factor; Swiss-Prot: sp|Q9SSD2|PRP8A_ARATH Pre-mRNA-processing-splicing factor 8A; TrEMBL-Plants: tr|V7BXW4|V7BXW4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0008200 | 35 | ||
| – | Pre-mRNA-processing-splicing factor 8; TAIR: AT1G80070.1 Pre-mRNA-processing-splicing factor; Swiss-Prot: sp|Q9SSD2|PRP8A_ARATH Pre-mRNA-processing-splicing factor 8A; TrEMBL-Plants: tr|V7BXW4|V7BXW4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0008200 | 35 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd13838 | CDD | 1 | 20.00 |