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IPR019582 is a RNA recognition motif, spliceosomal PrP8.
<p>The large RNA-protein complex of the spliceosome catalyses pre-mRNA splicing. One of the most conserved core proteins is the pre-mRNA-processing-splicing factor 8 (PrP8) which occupies a central position in the catalytic core of the spliceosome, and has been implicated in several crucial molecular rearrangements that occur there, and has recently come under the spotlight for its role in the inherited human disease, Retinitis Pigmentosa [[cite:PUB00044473]]. The RNA-recognition motif of PrP8 is highly conserved and provides a possible RNA binding centre for the 5-prime SS, BP, or 3-prime SS of pre-mRNA which are known to contact with Prp8. The most conserved regions of an RNA- recognition-motif (RRM) are defined as the RNP1 and RNP2 sequences. Recognition of RNA targets can also be modulated by a number of other factors, most notably the two loops beta1-alpha1, beta2-beta3 and the amino acid residues C-terminal to the RNP2 domain [[cite:PUB00044474]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | RNA binding | Interacting selectively and non-covalently with an RNA molecule or a portion thereof. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: pre-mRNA-processing-splicing factor 8-like [Cicer arietinum] gi|502080722|ref|XP_004486659.1| | 21 | ||
| – | Pre-mRNA-processing-splicing factor 8; TAIR: AT1G80070.1 Pre-mRNA-processing-splicing factor; Swiss-Prot: sp|Q9SSD2|PRP8A_ARATH Pre-mRNA-processing-splicing factor 8A; TrEMBL-Plants: tr|V7BXW4|V7BXW4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0008200 | 36 | ||
| – | Pre-mRNA-processing-splicing factor 8; TAIR: AT1G80070.1 Pre-mRNA-processing-splicing factor; Swiss-Prot: sp|Q9SSD2|PRP8A_ARATH Pre-mRNA-processing-splicing factor 8A; TrEMBL-Plants: tr|V7BXW4|V7BXW4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0008200 | 35 | ||
| – | Pre-mRNA-processing-splicing factor 8; TAIR: AT1G80070.1 Pre-mRNA-processing-splicing factor; Swiss-Prot: sp|Q9SSD2|PRP8A_ARATH Pre-mRNA-processing-splicing factor 8A; TrEMBL-Plants: tr|V7BXW4|V7BXW4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0008200 | 35 | ||
| – | Pre-mRNA-processing-splicing factor 8; TAIR: AT1G80070.1 Pre-mRNA-processing-splicing factor; Swiss-Prot: sp|Q9SSD2|PRP8A_ARATH Pre-mRNA-processing-splicing factor 8A; TrEMBL-Plants: tr|V7BXW4|V7BXW4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0008200 | 35 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd13838 | CDD | 1 | 20.00 |