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IPR021983 is a PRP8 domain IV core.
<p>This entry represents Prp8 domain IV, which adopts a RNase H like fold within its core structure but with little sequence similarity. Pre-mRNA-splicing factor 8 (Prp8), a spliceosome protein, interacts directly with the splice sites and branch regions of precursor-mRNAs and spliceosomal RNAs associated with catalysis of the two steps of splicing. Catalysis of RNA cleavage by RNase H-like proteins involves a two-metal mechanism in which adjacently-bound divalent magnesium ions promote hydrolysis by activation of a water nucleophile and stabilization of the transition-state. However, the Prp8 domain IV contains only one of the canonical metal-binding sites and the coordinating side chains are spatially conserved with respect to Mg2+-coordinating residues within the RNase H fold [[cite:PUB00051743]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: pre-mRNA-processing-splicing factor 8-like [Cicer arietinum] gi|502080722|ref|XP_004486659.1| | 21 | ||
| – | Pre-mRNA-processing-splicing factor 8; TAIR: AT1G80070.1 Pre-mRNA-processing-splicing factor; Swiss-Prot: sp|Q9SSD2|PRP8A_ARATH Pre-mRNA-processing-splicing factor 8A; TrEMBL-Plants: tr|V7BXW4|V7BXW4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0008200 | 36 | ||
| – | Pre-mRNA-processing-splicing factor 8; TAIR: AT1G80070.1 Pre-mRNA-processing-splicing factor; Swiss-Prot: sp|Q9SSD2|PRP8A_ARATH Pre-mRNA-processing-splicing factor 8A; TrEMBL-Plants: tr|V7BXW4|V7BXW4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0008200 | 35 | ||
| – | Pre-mRNA-processing-splicing factor 8; TAIR: AT1G80070.1 Pre-mRNA-processing-splicing factor; Swiss-Prot: sp|Q9SSD2|PRP8A_ARATH Pre-mRNA-processing-splicing factor 8A; TrEMBL-Plants: tr|V7BXW4|V7BXW4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0008200 | 35 | ||
| – | Pre-mRNA-processing-splicing factor 8; TAIR: AT1G80070.1 Pre-mRNA-processing-splicing factor; Swiss-Prot: sp|Q9SSD2|PRP8A_ARATH Pre-mRNA-processing-splicing factor 8A; TrEMBL-Plants: tr|V7BXW4|V7BXW4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0008200 | 35 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd13838 | CDD | 1 | 20.00 |