Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR027652 is a Pre-mRNA-processing-splicing factor 8.
<p>Pre-mRNA-processing-splicing factor 8 (Prp8) is a central component of the spliceosome, which may play a role in aligning the pre-mRNA 5'- and 3'-exons for ligation. It interacts with U5 snRNA, and with pre-mRNA 5'-splice sites in B spliceosomes and 3'-splice sites in C spliceosomes. It is part of the U5 snRNP complex, and of U5.4/6 and U5.U4atac/U6atac snRNP complexes in U2- and U12-dependent spliceosomes, respectively. It is also found in a mRNA splicing-dependent exon junction complex (EJC) with SRRM1 where it interacts with U5 snRNP proteins SNRP116 and WDR57/SPF38 [[cite:PUB00044473], [cite:PUB00044758]].</p> <p>Mutations of human Prp8 cause retinitis pigmentosa 13, a retinal dystrophy belonging to the group of pigmentary retinopathies [[cite:PUB00066910]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | MRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. | ||
| Cellular component | Spliceosomal complex | Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Pre-mRNA-processing-splicing factor [Medicago truncatula] gi|357455267|ref|XP_003597914.1| | 9 | ||
| – | Pre-mRNA-processing-splicing factor [Medicago truncatula] gi|357455267|ref|XP_003597914.1| | 8 | ||
| – | PREDICTED: pre-mRNA-processing-splicing factor 8-like [Cicer arietinum] gi|502080722|ref|XP_004486659.1| | 21 | ||
| – | Pre-mRNA-processing-splicing factor 8; TAIR: AT1G80070.1 Pre-mRNA-processing-splicing factor; Swiss-Prot: sp|Q9SSD2|PRP8A_ARATH Pre-mRNA-processing-splicing factor 8A; TrEMBL-Plants: tr|V7BXW4|V7BXW4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0008200 | 36 | ||
| – | Pre-mRNA-processing-splicing factor 8; TAIR: AT1G80070.1 Pre-mRNA-processing-splicing factor; Swiss-Prot: sp|Q9SSD2|PRP8A_ARATH Pre-mRNA-processing-splicing factor 8A; TrEMBL-Plants: tr|V7BXW4|V7BXW4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0008200 | 35 | ||
| – | Pre-mRNA-processing-splicing factor 8; TAIR: AT1G80070.1 Pre-mRNA-processing-splicing factor; Swiss-Prot: sp|Q9SSD2|PRP8A_ARATH Pre-mRNA-processing-splicing factor 8A; TrEMBL-Plants: tr|V7BXW4|V7BXW4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0008200 | 35 | ||
| – | Pre-mRNA-processing-splicing factor 8; TAIR: AT1G80070.1 Pre-mRNA-processing-splicing factor; Swiss-Prot: sp|Q9SSD2|PRP8A_ARATH Pre-mRNA-processing-splicing factor 8A; TrEMBL-Plants: tr|V7BXW4|V7BXW4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0008200 | 35 | ||
| – | Pre-mRNA-processing-splicing factor 8; TAIR: AT1G80070.1 Pre-mRNA-processing-splicing factor; Swiss-Prot: sp|Q9SSD2|PRP8A_ARATH Pre-mRNA-processing-splicing factor 8A; TrEMBL-Plants: tr|A0A151SPN6|A0A151SPN6_CAJCA Pre-mRNA-processing-splicing factor 8; Found in the gene: LotjaGi3g1v0008200 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR11140:SF1 | PANTHER | 1 | 12.50 |