Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR025792 is a tRNA (guanine(37)-N(1))-methyltransferase, eukaryotic.
<p>This entry represents RNA (guanine(37)-N(1))-methyltransferase from eukaryotes. This enzyme specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs [[cite:PUB00058053]].</p> <p>Methyltransferases (EC [ec:2.1.1.-]) constitute an important class of enzymes present in every life form. They transfer a methyl group most frequently from S-adenosyl L-methionine (SAM or AdoMet) to a nucleophilic acceptor such as oxygen leading to S-adenosyl-L-homocysteine (AdoHcy) and a methylated molecule [[cite:PUB00057957], [cite:PUB00057958], [cite:PUB00054125]]. All these enzymes have in common a conserved region of about 130 amino acid residues that allow them to bind SAM [[cite:PUB00006319]]. The substrates that are methylated by these enzymes cover virtually every kind of biomolecules ranging from small molecules, to lipids, proteins and nucleic acids [[cite:PUB00057957], [cite:PUB00057958], [cite:PUB00006319]]. Methyltransferase are therefore involved in many essential cellular processes including biosynthesis, signal transduction, protein repair, chromatin regulation and gene silencing [[cite:PUB00057957], [cite:PUB00057958], [cite:PUB00054125]]. More than 230 families of methyltransferases have been described so far, of which more than 220 use SAM as the methyl donor.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | TRNA (guanine-N1-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine. | ||
| Biological process | TRNA methylation | The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | SAM (and some other nucleotide) binding motif [Medicago truncatula] gi|124359271|gb|ABN05774.1| | 13 | ||
| – | TRNA (guanine(37)-N1)-methyltransferase; TAIR: AT4G27340.1 Met-10+ like family protein; Swiss-Prot: sp|F6H2F8|TRM51_VITVI tRNA (guanine(37)-N1)-methyltransferase 1; TrEMBL-Plants: tr|A0A151SVP0|A0A151SVP0_CAJCA tRNA (guanine(37)-N1)-methyltransferase; Found in the gene: LotjaGi3g1v0079700 | 20 | ||
| – | TRNA (guanine(37)-N1)-methyltransferase; TAIR: AT4G27340.1 Met-10+ like family protein; Swiss-Prot: sp|F6H2F8|TRM51_VITVI tRNA (guanine(37)-N1)-methyltransferase 1; TrEMBL-Plants: tr|A0A0B2R1V7|A0A0B2R1V7_GLYSO tRNA (guanine(37)-N1)-methyltransferase; Found in the gene: LotjaGi3g1v0079700 | 13 | ||
| – | TRNA (guanine(37)-N1)-methyltransferase; TAIR: AT4G27340.1 Met-10+ like family protein; Swiss-Prot: sp|F6H2F8|TRM51_VITVI tRNA (guanine(37)-N1)-methyltransferase 1; TrEMBL-Plants: tr|A0A151SVP0|A0A151SVP0_CAJCA tRNA (guanine(37)-N1)-methyltransferase; Found in the gene: LotjaGi3g1v0079700 | 13 | ||
| – | TRNA (guanine(37)-N1)-methyltransferase; TAIR: AT3G56120.1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|F6HH45|TRM52_VITVI tRNA (guanine(37)-N1)-methyltransferase 2; TrEMBL-Plants: tr|A0A0B2Q1C8|A0A0B2Q1C8_GLYSO tRNA (guanine(37)-N1)-methyltransferase; Found in the gene: LotjaGi4g1v0032800 | 13 | ||
| – | TRNA (guanine(37)-N1)-methyltransferase; TAIR: AT3G56120.1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|F6HH45|TRM52_VITVI tRNA (guanine(37)-N1)-methyltransferase 2; TrEMBL-Plants: tr|A0A0B2Q1C8|A0A0B2Q1C8_GLYSO tRNA (guanine(37)-N1)-methyltransferase; Found in the gene: LotjaGi4g1v0032800 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 16.67 |