Description

IPR027302 is a Glutamine synthetase, N-terminal conserved site.

<p>Glutamine synthetase ([ec:6.3.1.2]) (GS) [[cite:PUB00000993]] plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine.</p> <p>There seem to be three different classes of GS [[cite:PUB00004813], [cite:PUB00003408], [cite:PUB00003430]]: <ul> <li>Class I enzymes (GSI) are specific to prokaryotes, and are oligomers of 12 identical subunits. The activity of GSI-type enzyme is controlled by the adenylation of a tyrosine residue. The adenylated enzyme is inactive (see [interpro:IPR001637]).</li> <li>Class II enzymes (GSII) are found in eukaryotes and in bacteria belonging to the Rhizobiaceae, Frankiaceae, and Streptomycetaceae families (these bacteria have also a class-I GS). GSII are octamer of identical subunits. Plants have two or more isozymes of GSII, one of the isozymes is translocated into the chloroplast.</li> <li>Class III enzymes (GSIII) has, currently, only been found in Bacteroides fragilis and in Butyrivibrio fibrisolvens. It is a hexamer of identical chains. It is much larger (about 700 amino acids) than the GSI (450 to 470 amino acids) or GSII (350 to 420 amino acids) enzymes.</li> </ul> <p>While the three classes of GS's are clearly structurally related, the sequence similarities are not so extensive.</p> <p>This entry represents a conserved tetrapeptide in the N-terminal section of the enzyme.</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 13

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: