Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR014746 is a Glutamine synthetase/guanido kinase, catalytic domain.
<p>The C-terminal catalytic domains of glutamine synthetase and the guanido kinase family (which includes creatine kinase and arginine kinase) share a common structural fold, namely a common core consisting of two β-α-β2-α repeats [[cite:PUB00034749]].</p> <p>Glutamine synthetase ([ec:6.3.1.2]) (GS) [[cite:PUB00006495]] plays an essential role in the metabolism of nitrogen by catalysing the condensation of glutamate and ammonia to form glutamine. There seem to be three different classes of GS [[cite:PUB00004813], [cite:PUB00003408], [cite:PUB00003430]]. Class I enzymes (GSI) are specific to prokaryotes, and are oligomers of 12 identical subunits; the activity of GSI-type enzyme is controlled by the adenylation of a tyrosine residue. Class II enzymes (GSII) are found in eukaryotes and in bacteria, and are oligomers of 8 identical subunits. Class III enzymes (GSIII) have been found in Bacteroides fragilis in Butyrivibrio fibrisolvens, and are oligomers of six identical subunits. While the three classes of GS's are clearly structurally related, the sequence similarities are not so extensive.</p> <p>ATP:guanido phosphotransferases are a family of structurally and functionally related enzymes [[cite:PUB00002616], [cite:PUB00000670]] that reversibly catalyse the transfer of phosphate between ATP and various phosphogens. The enzymes belonging to this family include:</p> <ul> <li>Glycocyamine kinase ([ec:2.7.3.1]), which catalyses the transfer of phosphate from ATP to guanidoacetate.</li> <li>Arginine kinase ([ec:2.7.3.3]), which catalyses the transfer of phosphate from ATP to arginine.</li> <li>Taurocyamine kinase ([ec:2.7.3.4]), an annelid-specific enzyme that catalyses the transfer of phosphate from ATP to taurocyamine.</li> <li>Lombricine kinase ([ec:2.7.3.5]), an annelid-specific enzyme that catalyses the transfer of phosphate from ATP to lombricine.</li> <li>Smc74, a cercaria-specific enzyme from Schistosoma mansoni [[cite:PUB00002616]].</li> <li>Creatine kinase ([ec:2.7.3.2]) (CK) [[cite:PUB00000040], [cite:PUB00002619]], which plays an important role in energy metabolism of vertebrates.</li> </ul>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Molecular function | Catalytic activity | Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | RecName: Full=Glutamine synthetase nodule isozyme; Short=GS; AltName: Full=Glutamate--ammonia ligasegi|170637|gb|AAA34239.1| glutamine synthetase [Vigna aconitifolia] gi|417060|sp|P32289.1|GLNA_VIGAC | 13 | ||
– | Cytosolic glutamine synthetase [Securigera parviflora] gi|30692028|gb|AAP33169.1| | 16 | ||
– | PREDICTED: protein fluG-like isoform X1 [Cicer arietinum] gi|502122093|ref|XP_004497575.1| | 16 | ||
– | PREDICTED: protein fluG-like isoform X1 [Cicer arietinum] gi|502122093|ref|XP_004497575.1| | 14 | ||
– | Glutamine synthetase [Lotus japonicus] gi|2073448|emb|CAA73366.1| | 8 | ||
– | Glutamine synthetase [Lotus japonicus] gi|2073448|emb|CAA73366.1| | 8 | ||
– | Glutamine synthetase [Lotus japonicus] gi|26892201|gb|AAN84563.1| | 15 | ||
– | Glutamine synthetase [Lotus japonicus] gi|26892201|gb|AAN84563.1| | 15 | ||
– | Glutamine synthetase [Lotus japonicus] gi|26892201|gb|AAN84563.1| | 15 | ||
– | Glutamine synthetase; TAIR: AT5G37600.1 hypothetical protein; Swiss-Prot: sp|P32289|GLNA_VIGAC Glutamine synthetase nodule isozyme; TrEMBL-Plants: tr|A0A0S3RZR8|A0A0S3RZR8_PHAAN Glutamine synthetase; Found in the gene: LotjaGi1g1v0095400 | 17 | ||
– | Glutamine synthetase; TAIR: AT5G37600.1 hypothetical protein; Swiss-Prot: sp|P32289|GLNA_VIGAC Glutamine synthetase nodule isozyme; TrEMBL-Plants: tr|A0A0S3RZR8|A0A0S3RZR8_PHAAN Glutamine synthetase; Found in the gene: LotjaGi1g1v0095400 | 17 | ||
– | Glutamine synthetase; TAIR: AT5G37600.1 hypothetical protein; Swiss-Prot: sp|Q43785|GLNA3_MEDSA Glutamine synthetase nodule isozyme; TrEMBL-Plants: tr|I3T8A0|I3T8A0_LOTJA Glutamine synthetase; Found in the gene: LotjaGi2g1v0192900 | 17 | ||
– | Glutamate-cysteine ligase; TAIR: AT4G23100.1 glutamate-cysteine ligase; Swiss-Prot: sp|P46309|GSH1_ARATH Glutamate--cysteine ligase, chloroplastic; TrEMBL-Plants: tr|G7KC28|G7KC28_MEDTR Glutamate-cysteine ligase B; Found in the gene: LotjaGi2g1v0434100 | 11 | ||
– | Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; TAIR: AT1G48520.1 GLU-ADT subunit B; Swiss-Prot: sp|B9SQR9|GATB_RICCO Glutamyl-tRNA(Gln) amidotransferase subunit B, chloroplastic/mitochondrial; TrEMBL-Plants: tr|I1KQC8|I1KQC8_SOYBN Glutamyl-tRNA(Gln) amidotransferase subunit B, chloroplastic/mitochondrial; Found in the gene: LotjaGi4g1v0219600 | 27 | ||
– | Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; TAIR: AT1G48520.1 GLU-ADT subunit B; Swiss-Prot: sp|B9SQR9|GATB_RICCO Glutamyl-tRNA(Gln) amidotransferase subunit B, chloroplastic/mitochondrial; TrEMBL-Plants: tr|I1KQC8|I1KQC8_SOYBN Glutamyl-tRNA(Gln) amidotransferase subunit B, chloroplastic/mitochondrial; Found in the gene: LotjaGi4g1v0219600 | 27 | ||
– | Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; TAIR: AT1G48520.1 GLU-ADT subunit B; Swiss-Prot: sp|B9SQR9|GATB_RICCO Glutamyl-tRNA(Gln) amidotransferase subunit B, chloroplastic/mitochondrial; TrEMBL-Plants: tr|I1KQC8|I1KQC8_SOYBN Glutamyl-tRNA(Gln) amidotransferase subunit B, chloroplastic/mitochondrial; Found in the gene: LotjaGi4g1v0219600 | 27 | ||
– | Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; TAIR: AT1G48520.1 GLU-ADT subunit B; Swiss-Prot: sp|B9SQR9|GATB_RICCO Glutamyl-tRNA(Gln) amidotransferase subunit B, chloroplastic/mitochondrial; TrEMBL-Plants: tr|I1KQC8|I1KQC8_SOYBN Glutamyl-tRNA(Gln) amidotransferase subunit B, chloroplastic/mitochondrial; Found in the gene: LotjaGi4g1v0219600 | 27 | ||
– | Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; TAIR: AT1G48520.1 GLU-ADT subunit B; Swiss-Prot: sp|B9SQR9|GATB_RICCO Glutamyl-tRNA(Gln) amidotransferase subunit B, chloroplastic/mitochondrial; TrEMBL-Plants: tr|I1KQC8|I1KQC8_SOYBN Glutamyl-tRNA(Gln) amidotransferase subunit B, chloroplastic/mitochondrial; Found in the gene: LotjaGi4g1v0219600 | 27 | ||
– | Glutamate--cysteine ligase, chloroplastic; TAIR: AT4G23100.1 glutamate-cysteine ligase; Swiss-Prot: sp|Q9ZNX6|GSH1_MEDTR Glutamate--cysteine ligase, chloroplastic; TrEMBL-Plants: tr|Q6XXZ2|Q6XXZ2_LOTJA Gamma-glutamylcysteine synthetase; Found in the gene: LotjaGi4g1v0425600 | 11 | ||
– | Glutamate--cysteine ligase, chloroplastic; TAIR: AT4G23100.1 glutamate-cysteine ligase; Swiss-Prot: sp|Q9ZNX6|GSH1_MEDTR Glutamate--cysteine ligase, chloroplastic; TrEMBL-Plants: tr|Q6XXZ2|Q6XXZ2_LOTJA Gamma-glutamylcysteine synthetase; Found in the gene: LotjaGi4g1v0425600 | 11 | ||
– | Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; TAIR: AT1G48520.1 GLU-ADT subunit B; Swiss-Prot: sp|B9SQR9|GATB_RICCO Glutamyl-tRNA(Gln) amidotransferase subunit B, chloroplastic/mitochondrial; TrEMBL-Plants: tr|I1KQC8|I1KQC8_SOYBN Glutamyl-tRNA(Gln) amidotransferase subunit B, chloroplastic/mitochondrial; Found in the gene: LotjaGi4g1v0457900 | 27 | ||
– | Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; TAIR: AT1G48520.1 GLU-ADT subunit B; Swiss-Prot: sp|B9SQR9|GATB_RICCO Glutamyl-tRNA(Gln) amidotransferase subunit B, chloroplastic/mitochondrial; TrEMBL-Plants: tr|I1KQC8|I1KQC8_SOYBN Glutamyl-tRNA(Gln) amidotransferase subunit B, chloroplastic/mitochondrial; Found in the gene: LotjaGi4g1v0457900 | 27 | ||
– | Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; TAIR: AT1G48520.1 GLU-ADT subunit B; Swiss-Prot: sp|B9SQR9|GATB_RICCO Glutamyl-tRNA(Gln) amidotransferase subunit B, chloroplastic/mitochondrial; TrEMBL-Plants: tr|I1KQC8|I1KQC8_SOYBN Glutamyl-tRNA(Gln) amidotransferase subunit B, chloroplastic/mitochondrial; Found in the gene: LotjaGi4g1v0457900 | 27 | ||
– | Glutamine synthetase; TAIR: AT3G53180.1 nodulin/glutamine synthase-like protein; Swiss-Prot: sp|P38094|FLUG_EMENI Protein fluG; TrEMBL-Plants: tr|A0A072VVL5|A0A072VVL5_MEDTR Glutamate-ammonia ligase-like protein; Found in the gene: LotjaGi5g1v0085200 | 14 | ||
– | Glutamine synthetase; TAIR: AT3G53180.1 nodulin/glutamine synthase-like protein; Swiss-Prot: sp|P38094|FLUG_EMENI Protein fluG; TrEMBL-Plants: tr|I1L922|I1L922_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0085200 | 16 | ||
– | Glutamine synthetase; TAIR: AT5G37600.1 hypothetical protein; Swiss-Prot: sp|Q42899|GLNA1_LOTJA Glutamine synthetase cytosolic isozyme; TrEMBL-Plants: tr|Q84L17|Q84L17_9FABA Glutamine synthetase; Found in the gene: LotjaGi6g1v0055300 | 18 | ||
– | Glutamine synthetase; TAIR: AT5G37600.1 hypothetical protein; Swiss-Prot: sp|Q42899|GLNA1_LOTJA Glutamine synthetase cytosolic isozyme; TrEMBL-Plants: tr|Q84L17|Q84L17_9FABA Glutamine synthetase; Found in the gene: LotjaGi6g1v0055300 | 18 | ||
– | Glutamine synthetase; TAIR: AT5G35630.1 glutamine synthetase 2; Swiss-Prot: sp|Q9XQ94|GLNA2_MEDSA Glutamine synthetase leaf isozyme, chloroplastic; TrEMBL-Plants: tr|Q8GT61|Q8GT61_LOTJA Glutamine synthetase; Found in the gene: LotjaGi6g1v0300700 | 17 | ||
– | Glutamine synthetase; TAIR: AT5G35630.1 glutamine synthetase 2; Swiss-Prot: sp|Q9XQ94|GLNA2_MEDSA Glutamine synthetase leaf isozyme, chloroplastic; TrEMBL-Plants: tr|Q8GT61|Q8GT61_LOTJA Glutamine synthetase; Found in the gene: LotjaGi6g1v0300700 | 17 | ||
– | Glutamine synthetase; TAIR: AT5G35630.1 glutamine synthetase 2; Swiss-Prot: sp|Q9XQ94|GLNA2_MEDSA Glutamine synthetase leaf isozyme, chloroplastic; TrEMBL-Plants: tr|Q8GT61|Q8GT61_LOTJA Glutamine synthetase; Found in the gene: LotjaGi6g1v0300700 | 13 | ||
– | Glutamine synthetase; TAIR: AT5G35630.1 glutamine synthetase 2; Swiss-Prot: sp|Q9XQ94|GLNA2_MEDSA Glutamine synthetase leaf isozyme, chloroplastic; TrEMBL-Plants: tr|Q8GT61|Q8GT61_LOTJA Glutamine synthetase; Found in the gene: LotjaGi6g1v0300700 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
SSF55931 | SUPERFAMILY | 1 | 3.23 |