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IPR028468 is a Smc1, ATP-binding cassette domain.
<p>This entry represents the ATP-binding cassette domain of eukaryotic Smc1 proteins.</p> <p>Smc1 (Structural maintenance of chromosomes protein 1) is involved in chromosome cohesion during cell cycle and in DNA repair. In eukaryotes, the Smc1-Smc3 heterodimer is part of the cohesin complex, which is required for the cohesion of sister chromatids after DNA replication [[cite:PUB00068475], [cite:PUB00068892], [cite:PUB00007543]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Chromatin binding | Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. | ||
| Biological process | Mitotic sister chromatid cohesion | The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission. | ||
| Cellular component | Cohesin complex | A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3). | ||
| Molecular function | Protein heterodimerization activity | Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Structural maintenance of chromosomes protein; TAIR: AT3G54670.1 Structural maintenance of chromosomes (SMC) family protein; Swiss-Prot: sp|Q6Q1P4|SMC1_ARATH Structural maintenance of chromosomes protein 1; TrEMBL-Plants: tr|A0A0S3SRB6|A0A0S3SRB6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0181700 | 12 | ||
| – | Structural maintenance of chromosomes protein; TAIR: AT3G54670.1 Structural maintenance of chromosomes (SMC) family protein; Swiss-Prot: sp|Q6Q1P4|SMC1_ARATH Structural maintenance of chromosomes protein 1; TrEMBL-Plants: tr|A0A0S3SRB6|A0A0S3SRB6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0181700 | 12 | ||
| – | Structural maintenance of chromosomes protein; TAIR: AT3G54670.1 Structural maintenance of chromosomes (SMC) family protein; Swiss-Prot: sp|Q6Q1P4|SMC1_ARATH Structural maintenance of chromosomes protein 1; TrEMBL-Plants: tr|A0A0B2P8J7|A0A0B2P8J7_GLYSO Structural maintenance of chromosomes protein; Found in the gene: LotjaGi5g1v0181700 | 21 | ||
| – | Structural maintenance of chromosomes protein; TAIR: AT3G54670.1 Structural maintenance of chromosomes (SMC) family protein; Swiss-Prot: sp|Q6Q1P4|SMC1_ARATH Structural maintenance of chromosomes protein 1; TrEMBL-Plants: tr|I1LYK3|I1LYK3_SOYBN Structural maintenance of chromosomes protein; Found in the gene: LotjaGi5g1v0181700 | 17 | ||
| – | Structural maintenance of chromosomes protein; TAIR: AT3G54670.1 Structural maintenance of chromosomes (SMC) family protein; Swiss-Prot: sp|Q6Q1P4|SMC1_ARATH Structural maintenance of chromosomes protein 1; TrEMBL-Plants: tr|A0A0S3SR98|A0A0S3SR98_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0181700 | 20 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd03275 | CDD | 1 | 20.00 |