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IPR029710

Source: InterPro

Description

IPR029710 is a DNA ligase 4.

<p>DNA ligase 4 (LIG4) is involved in DNA double-strand break repair [[cite:PUB00070667]]. In higher eukaryotes it forms a complex with XRCC4, which is responsible for the ligation step during the DNA-PK-dependent non-homologous end joining (D-NHEJ) [[cite:PUB00070668], [cite:PUB00070670], [cite:PUB00106867]]. The Ku component of the DNA-PK (DNA-dependent protein kinase) complex contributes to the recruitment of the LIG4-XRCC4 complex at the DNA break site [[cite:PUB00070668]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003677
Molecular function DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
Subterm of
GO:0003910
Molecular function DNA ligase (ATP) activity Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m).
Subterm of
GO:0005524
Molecular function ATP binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
Subterm of
GO:0006281
Biological process DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
Subterm of
GO:0051103
Biological process DNA ligation involved in DNA repair The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair.
Subterm of
Part of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
LotjaGi6g1v0235200.1
– DNA ligase; TAIR: AT5G57160.2 DNA ligase IV; Swiss-Prot: sp|Q9LL84|DNLI4_ARATH DNA ligase 4; TrEMBL-Plants: tr|K7MBU8|K7MBU8_SOYBN DNA ligase; Found in the gene: LotjaGi6g1v0235200
Domains
26
LotjaGi6g1v0235200.2
– DNA ligase; TAIR: AT5G57160.1 DNA ligase IV; Swiss-Prot: sp|Q9LL84|DNLI4_ARATH DNA ligase 4; TrEMBL-Plants: tr|K7MBU8|K7MBU8_SOYBN DNA ligase; Found in the gene: LotjaGi6g1v0235200
Domains
36

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 50.00