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IPR030391 is a RNA methyltransferase TrmA, conserved site.
<p>In Escherichia coli, the trmA protein is a tRNA (uracil-5-)-methyltransferase ([ec:2.1.1.35]) that catalyses the S-adenosylmethionine dependent methylation of U54 in all tRNAs. Orthologues of trmA are found in many eubacterial species. A number of uncharacterised homologues of trmA have been found [[cite:PUB00004469]]:</p> <ul> <li>Escherichia coli hypothetical protein ygcA and HI0333, the corresponding Haemophilus influenzae protein.</li> <li>Haemophilus influenzae hypothetical protein HI0958.</li> <li>Chlamydia trachomatis protein HOM1.</li> <li>Fission yeast hypothetical protein SpAC4G8.07c.</li> </ul> <p>It is probable that ygcA/HI0333 and HI0958 are responsible for the methylation of U747 and U1939 in 23S rRNA. In trmA, a cysteine is known to participate in the catalytic mechanism by forming a covalent adduct to C6 of uracil.</p> <p>This entry represents a conserved site located at the C-terminal end. It contains a conserved histidine.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | 23S rRNA (uracil-5-)-methyltransferase rumA [Medicago truncatula] gi|357454725|ref|XP_003597643.1| | 13 | ||
| – | 23S rRNA (Uracil-5-)-methyltransferase; TAIR: AT3G21300.1 RNA methyltransferase family protein; Swiss-Prot: sp|Q8KGF9|Y009_CHLTE Uncharacterized RNA methyltransferase CT0009; TrEMBL-Plants: tr|G7IHW5|G7IHW5_MEDTR 23S rRNA (Uracil-5)-methyltransferase RumA; Found in the gene: LotjaGi3g1v0022800 | 18 | ||
| – | 23S rRNA (Uracil-5-)-methyltransferase; TAIR: AT3G21300.1 RNA methyltransferase family protein; Swiss-Prot: sp|Q8KGF9|Y009_CHLTE Uncharacterized RNA methyltransferase CT0009; TrEMBL-Plants: tr|G7IHW5|G7IHW5_MEDTR 23S rRNA (Uracil-5)-methyltransferase RumA; Found in the gene: LotjaGi3g1v0022800 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd02440 | CDD | 1 | 33.33 |