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IPR031099

Source: InterPro

Description

IPR031099 is a BRCA1-associated.

<p>This entry includes animal BRCA1 (BREAST CANCER SUSCEPTIBILITY 1) proteins and their homologues from plants [[cite:PUB00074533]].</p> <p>The animal BRCA1 protein is a E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage [[cite:PUB00017952], [cite:PUB00066908]]. It contains an N-terminal zinc-finger domain. It also contains a BRCT C-terminal domain, an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain [[cite:PUB00014805]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0006281
Biological process DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
Subterm of
GO:0006974
Biological process Cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
Subterm of

Associated Lotus transcripts 7

Transcript Name Description Predicted domains Domain count
Lj0g3v0294399.1
– PREDICTED: protein BREAST CANCER SUSCEPTIBILITY 1 homolog [Cicer arietinum] gi|502110153|ref|XP_004493812.1|
Domains
22
Lj1g3v4515780.1
– PREDICTED: protein BREAST CANCER SUSCEPTIBILITY 1 homolog [Cicer arietinum] gi|502110153|ref|XP_004493812.1|
Domains
4
Lj6g3v1946520.1
– PREDICTED: protein BREAST CANCER SUSCEPTIBILITY 1 homolog [Glycine max] gi|356557797|ref|XP_003547197.1|
Domains
14
Lj6g3v1946530.1
– PREDICTED: protein BREAST CANCER SUSCEPTIBILITY 1 homolog [Glycine max] gi|356557797|ref|XP_003547197.1|
Domains
13
LotjaGi1g1v0705900.1
– Breast cancer associated RING 1; TAIR: AT1G04020.1 breast cancer associated RING 1; Swiss-Prot: sp|F4I443|BARD1_ARATH BRCA1-associated RING domain protein 1; TrEMBL-Plants: tr|A0A0B2PNV8|A0A0B2PNV8_GLYSO Protein BREAST CANCER SUSCEPTIBILITY 1 like; Found in the gene: LotjaGi1g1v0705900
Domains
27
LotjaGi6g1v0299000_LC.1
– Protein BREAST CANCER SUSCEPTIBILITY 1 like; TAIR: AT1G04020.2 breast cancer associated RING 1; Swiss-Prot: sp|F4I443|BARD1_ARATH BRCA1-associated RING domain protein 1; TrEMBL-Plants: tr|A0A151QZT5|A0A151QZT5_CAJCA Protein BREAST CANCER SUSCEPTIBILITY 1 isogeny; Found in the gene: LotjaGi6g1v0299000_LC
Domains
6
LotjaGi6g1v0312100_LC.1
– Breast cancer associated RING 1; TAIR: AT4G21070.1 breast cancer susceptibility1; Swiss-Prot: sp|Q8RXD4|BRCA1_ARATH Protein BREAST CANCER SUSCEPTIBILITY 1 homolog; TrEMBL-Plants: tr|V7BPN4|V7BPN4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0312100_LC
Domains
30

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 14.29