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IPR032691 is a Mon2/Sec7/BIG1-like, HUS domain.
<p>This entry represent the HUS regulatory domain found towards the N terminus in guanine nucleotide exchange factors involved Golgi transport, such as budding yeast protein Sec7, protein Mon2 and BIG1-like proteins [[cite:PUB00101185], [cite:PUB00101184]].</p> <p>Sec7 and its homologues are guanine nucleotide exchange factors (GEFs) involved in the secretory pathway [[cite:PUB00076748]]. The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI [[cite:PUB00005683]]. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF [[cite:PUB00076747]].</p> <p>Mon2 is distantly related to the Arf1 guanine nucleotide exchange factors (GEFs), such as Sec7. However, it lacks the Sec7 domain that catalyses nucleotide exchange on Arf1. Instead, Mon2 acts as a scaffold to recruit the Golgi-localised pool of Dop1 [[cite:PUB00068242]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: pattern formation protein EMB30-like [Glycine max] gi|356569278|ref|XP_003552830.1| | 18 | ||
| – | PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 2-like [Cicer arietinum] gi|502104766|ref|XP_004492642.1| | 19 | ||
| – | PREDICTED: protein MON2 homolog isoform 2 [Glycine max] gi|356535141|ref|XP_003536107.1| | 12 | ||
| – | PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 2-like [Cicer arietinum] gi|502157877|ref|XP_004510941.1| | 29 | ||
| – | PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 5-like [Cicer arietinum] gi|502150646|ref|XP_004508055.1| | 25 | ||
| – | PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 5-like [Cicer arietinum] gi|502150646|ref|XP_004508055.1| | 23 | ||
| – | PREDICTED: ARF guanine-nucleotide exchange factor GNOM-like isoform X1 [Cicer arietinum] gi|502137738|ref|XP_004503168.1| | 19 | ||
| – | Brefeldin A-inhibited guanine nucleotide-exchange protein; TAIR: AT4G38200.1 SEC7-like guanine nucleotide exchange family protein; Swiss-Prot: sp|F4JSZ5|BIG1_ARATH Brefeldin A-inhibited guanine nucleotide-exchange protein 1; TrEMBL-Plants: tr|A0A0B2R8L7|A0A0B2R8L7_GLYSO Brefeldin A-inhibited guanine nucleotide-exchange protein 2; Found in the gene: LotjaGi1g1v0000200 | 18 | ||
| – | Brefeldin A-inhibited guanine nucleotide-exchange protein; TAIR: AT4G38200.1 SEC7-like guanine nucleotide exchange family protein; Swiss-Prot: sp|F4JSZ5|BIG1_ARATH Brefeldin A-inhibited guanine nucleotide-exchange protein 1; TrEMBL-Plants: tr|I1JJW7|I1JJW7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0000200 | 24 | ||
| – | Brefeldin A-inhibited guanine nucleotide-exchange protein; TAIR: AT4G38200.1 SEC7-like guanine nucleotide exchange family protein; Swiss-Prot: sp|F4JSZ5|BIG1_ARATH Brefeldin A-inhibited guanine nucleotide-exchange protein 1; TrEMBL-Plants: tr|A0A0B2R8L7|A0A0B2R8L7_GLYSO Brefeldin A-inhibited guanine nucleotide-exchange protein 2; Found in the gene: LotjaGi1g1v0000200 | 18 | ||
| – | Guanine nucleotide exchange family protein; TAIR: AT1G13980.1 sec7 domain-containing protein; Swiss-Prot: sp|Q42510|GNOM_ARATH ARF guanine-nucleotide exchange factor GNOM; TrEMBL-Plants: tr|K7M5B1|K7M5B1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0087500 | 20 | ||
| – | Guanine nucleotide exchange family protein; TAIR: AT1G13980.1 sec7 domain-containing protein; Swiss-Prot: sp|Q42510|GNOM_ARATH ARF guanine-nucleotide exchange factor GNOM; TrEMBL-Plants: tr|K7M5B1|K7M5B1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0087500 | 20 | ||
| – | Guanine nucleotide exchange family protein; TAIR: AT1G13980.1 sec7 domain-containing protein; Swiss-Prot: sp|Q42510|GNOM_ARATH ARF guanine-nucleotide exchange factor GNOM; TrEMBL-Plants: tr|K7M5B1|K7M5B1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0087500 | 20 | ||
| – | Guanine nucleotide exchange family protein; TAIR: AT1G13980.1 sec7 domain-containing protein; Swiss-Prot: sp|Q42510|GNOM_ARATH ARF guanine-nucleotide exchange factor GNOM; TrEMBL-Plants: tr|V7B7Q8|V7B7Q8_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0087500 | 20 | ||
| – | Brefeldin A-inhibited guanine nucleotide-exchange protein; TAIR: AT3G60860.1 SEC7-like guanine nucleotide exchange family protein; Swiss-Prot: sp|Q9LZX8|BIG2_ARATH Brefeldin A-inhibited guanine nucleotide-exchange protein 2; TrEMBL-Plants: tr|G7L099|G7L099_MEDTR Brefeldin A-inhibited guanine nucleotide-exchange protein; Found in the gene: LotjaGi1g1v0463300 | 26 | ||
| – | Brefeldin A-inhibited guanine nucleotide-exchange protein; TAIR: AT3G60860.1 SEC7-like guanine nucleotide exchange family protein; Swiss-Prot: sp|Q9LZX8|BIG2_ARATH Brefeldin A-inhibited guanine nucleotide-exchange protein 2; TrEMBL-Plants: tr|G7L099|G7L099_MEDTR Brefeldin A-inhibited guanine nucleotide-exchange protein; Found in the gene: LotjaGi1g1v0463300 | 26 | ||
| – | Brefeldin A-inhibited guanine nucleotide-exchange protein; TAIR: AT3G60860.1 SEC7-like guanine nucleotide exchange family protein; Swiss-Prot: sp|Q9LZX8|BIG2_ARATH Brefeldin A-inhibited guanine nucleotide-exchange protein 2; TrEMBL-Plants: tr|A0A151TB78|A0A151TB78_CAJCA Brefeldin A-inhibited guanine nucleotide-exchange protein 2; Found in the gene: LotjaGi1g1v0463300 | 24 | ||
| – | Guanine nucleotide exchange family protein; TAIR: AT5G19610.1 GNOM-like 2; Swiss-Prot: sp|F4K2K3|GNL2_ARATH ARF guanine-nucleotide exchange factor GNL2; TrEMBL-Plants: tr|G7KNH6|G7KNH6_MEDTR ARF guanine-nucleotide exchange factor GNOM protein; Found in the gene: LotjaGi2g1v0214000 | 19 | ||
| – | Brefeldin A-inhibited guanine nucleotide-exchange protein; TAIR: AT3G60860.1 SEC7-like guanine nucleotide exchange family protein; Swiss-Prot: sp|Q9LZX8|BIG2_ARATH Brefeldin A-inhibited guanine nucleotide-exchange protein 2; TrEMBL-Plants: tr|A0A0B2S605|A0A0B2S605_GLYSO Brefeldin A-inhibited guanine nucleotide-exchange protein 2; Found in the gene: LotjaGi3g1v0432300 | 24 | ||
| – | Brefeldin A-inhibited guanine nucleotide-exchange protein; TAIR: AT3G60860.1 SEC7-like guanine nucleotide exchange family protein; Swiss-Prot: sp|Q9LZX8|BIG2_ARATH Brefeldin A-inhibited guanine nucleotide-exchange protein 2; TrEMBL-Plants: tr|I1N3F3|I1N3F3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0432300 | 26 | ||
| – | Brefeldin A-inhibited guanine nucleotide-exchange protein; TAIR: AT3G43300.3 HOPM interactor 7; Swiss-Prot: sp|F4IXW2|BIG5_ARATH Brefeldin A-inhibited guanine nucleotide-exchange protein 5; TrEMBL-Plants: tr|A0A0B2SIY4|A0A0B2SIY4_GLYSO Brefeldin A-inhibited guanine nucleotide-exchange protein 2; Found in the gene: LotjaGi4g1v0318600 | 24 | ||
| – | Brefeldin A-inhibited guanine nucleotide-exchange protein; TAIR: AT3G43300.3 HOPM interactor 7; Swiss-Prot: sp|F4IXW2|BIG5_ARATH Brefeldin A-inhibited guanine nucleotide-exchange protein 5; TrEMBL-Plants: tr|A0A0B2SIY4|A0A0B2SIY4_GLYSO Brefeldin A-inhibited guanine nucleotide-exchange protein 2; Found in the gene: LotjaGi4g1v0318600 | 24 | ||
| – | Brefeldin A-inhibited guanine nucleotide-exchange protein; TAIR: AT3G43300.3 HOPM interactor 7; Swiss-Prot: sp|F4IXW2|BIG5_ARATH Brefeldin A-inhibited guanine nucleotide-exchange protein 5; TrEMBL-Plants: tr|A0A0B2SIY4|A0A0B2SIY4_GLYSO Brefeldin A-inhibited guanine nucleotide-exchange protein 2; Found in the gene: LotjaGi4g1v0318600 | 24 | ||
| – | Brefeldin A-inhibited guanine nucleotide-exchange protein; TAIR: AT3G43300.3 HOPM interactor 7; Swiss-Prot: sp|F4IXW2|BIG5_ARATH Brefeldin A-inhibited guanine nucleotide-exchange protein 5; TrEMBL-Plants: tr|A0A0B2SIY4|A0A0B2SIY4_GLYSO Brefeldin A-inhibited guanine nucleotide-exchange protein 2; Found in the gene: LotjaGi4g1v0318600 | 24 | ||
| – | Brefeldin A-inhibited guanine nucleotide-exchange protein; TAIR: AT3G43300.3 HOPM interactor 7; Swiss-Prot: sp|F4IXW2|BIG5_ARATH Brefeldin A-inhibited guanine nucleotide-exchange protein 5; TrEMBL-Plants: tr|A0A0B2SIY4|A0A0B2SIY4_GLYSO Brefeldin A-inhibited guanine nucleotide-exchange protein 2; Found in the gene: LotjaGi4g1v0318600 | 24 | ||
| – | Brefeldin A-inhibited guanine nucleotide-exchange protein; TAIR: AT5G27970.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9VLT1|MON2_DROME Protein MON2 homolog; TrEMBL-Plants: tr|K7LJP9|K7LJP9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0215500 | 13 | ||
| – | Brefeldin A-inhibited guanine nucleotide-exchange protein; TAIR: AT5G27970.3 ARM repeat superfamily protein; Swiss-Prot: sp|Q9VLT1|MON2_DROME Protein MON2 homolog; TrEMBL-Plants: tr|A0A0B2Q805|A0A0B2Q805_GLYSO Protein MON2 like; Found in the gene: LotjaGi5g1v0215500 | 13 | ||
| – | Brefeldin A-inhibited guanine nucleotide-exchange protein; TAIR: AT5G27970.3 ARM repeat superfamily protein; Swiss-Prot: sp|Q9VLT1|MON2_DROME Protein MON2 homolog; TrEMBL-Plants: tr|A0A0B2Q805|A0A0B2Q805_GLYSO Protein MON2 like; Found in the gene: LotjaGi5g1v0215500 | 13 | ||
| – | Brefeldin A-inhibited guanine nucleotide-exchange protein; TAIR: AT5G27970.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9VLT1|MON2_DROME Protein MON2 homolog; TrEMBL-Plants: tr|K7LJP9|K7LJP9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0215500 | 13 | ||
| – | Guanine nucleotide exchange family protein; TAIR: AT1G13980.1 sec7 domain-containing protein; Swiss-Prot: sp|Q42510|GNOM_ARATH ARF guanine-nucleotide exchange factor GNOM; TrEMBL-Plants: tr|A0A0L9U8L1|A0A0L9U8L1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0064200 | 20 | ||
| – | Guanine nucleotide exchange family protein; TAIR: AT1G13980.1 sec7 domain-containing protein; Swiss-Prot: sp|Q42510|GNOM_ARATH ARF guanine-nucleotide exchange factor GNOM; TrEMBL-Plants: tr|V7D1N8|V7D1N8_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0064200 | 21 | ||
| – | Guanine nucleotide exchange family protein; TAIR: AT1G13980.1 sec7 domain-containing protein; Swiss-Prot: sp|Q42510|GNOM_ARATH ARF guanine-nucleotide exchange factor GNOM; TrEMBL-Plants: tr|A0A0L9U8L1|A0A0L9U8L1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0064200 | 20 | ||
| – | Guanine nucleotide exchange family protein; TAIR: AT1G13980.1 sec7 domain-containing protein; Swiss-Prot: sp|Q42510|GNOM_ARATH ARF guanine-nucleotide exchange factor GNOM; TrEMBL-Plants: tr|I1MZA2|I1MZA2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0064300 | 20 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 3.03 |