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GO:0003916

View this GO term in other databases

Overview

Field Value
Namespace Molecular function
Short description DNA topoisomerase activity
Full defintion Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.
Subterm of

Relationships

The relationship of GO:0003916 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCmah
PMID
DNA topoisomerases.Wang JC
Annu Rev Biochem. 1996; 65 (): 635–92.PMID: 8811192

The various problems of disentangling DNA strands or duplexes in a cell are all rooted in the double-helical structure of DNA. Three distinct subfamilies of enzymes, known as the DNA topoisomerases, have evolved to solve these problems. This review focuses on work in the past decade on the mechanisms and cellular functions of these enzymes. Newly discovered members and recent biochemical and structural results are reviewed, and mechanistic implications of these results are summarized. The primary cellular functions of these enzymes, including their roles in replication, transcription, chromosome condensation, and the maintenance of genome stability, are then discussed. The review ends with a summary of the regulation of the cellular levels of these enzymes and a discussion of their association with other cellular proteins.

Associated Lotus transcripts 18

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj0g3v0069809.1
– PREDICTED: DNA topoisomerase 3-alpha-like [Cicer arietinum] gi|502137087|ref|XP_004502963.1|
GO terms
3
Lj0g3v0069819.1
– PREDICTED: DNA topoisomerase 3-alpha-like [Cicer arietinum] gi|502137087|ref|XP_004502963.1|
GO terms
3
Lj2g3v0146560.1
– PREDICTED: DNA gyrase subunit A, chloroplastic/mitochondrial-like isoform X1 [Cicer arietinum] gi|502127538|ref|XP_004499748.1|
GO terms
4
Lj5g3v0611970.1
– PREDICTED: DNA topoisomerase 1-like isoform X1 [Cicer arietinum] gi|502124515|ref|XP_004498560.1|
GO terms
4
Lj5g3v0611970.2
– PREDICTED: DNA topoisomerase 1-like isoform X1 [Cicer arietinum] gi|502124515|ref|XP_004498560.1|
GO terms
4
Lj6g3v0657890.1
– PREDICTED: DNA topoisomerase 3-beta-1-like [Glycine max] gi|356540116|ref|XP_003538536.1|
GO terms
3
LotjaGi1g1v0321800.1
– DNA topoisomerase; TAIR: AT5G63920.1 topoisomerase 3alpha; Swiss-Prot: sp|Q9LVP1|TOP3A_ARATH DNA topoisomerase 3-alpha; TrEMBL-Plants: tr|A0A0S3RFA9|A0A0S3RFA9_PHAAN DNA topoisomerase; Found in the gene: LotjaGi1g1v0321800
GO terms
4
LotjaGi2g1v0064900.1
– DNA gyrase subunit A; TAIR: AT3G10690.1 DNA GYRASE A; Swiss-Prot: sp|Q5YLB5|GYRA_NICBE DNA gyrase subunit A, chloroplastic/mitochondrial; TrEMBL-Plants: tr|G7I9Z9|G7I9Z9_MEDTR DNA gyrase subunit A; Found in the gene: LotjaGi2g1v0064900
GO terms
4
LotjaGi2g1v0064900.2
– DNA gyrase subunit A; TAIR: AT3G10690.1 DNA GYRASE A; Swiss-Prot: sp|Q5YLB5|GYRA_NICBE DNA gyrase subunit A, chloroplastic/mitochondrial; TrEMBL-Plants: tr|I1L2U5|I1L2U5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0064900
GO terms
4
LotjaGi2g1v0064900.3
– DNA gyrase subunit A; TAIR: AT3G10690.1 DNA GYRASE A; Swiss-Prot: sp|Q5YLB5|GYRA_NICBE DNA gyrase subunit A, chloroplastic/mitochondrial; TrEMBL-Plants: tr|G7I9Z9|G7I9Z9_MEDTR DNA gyrase subunit A; Found in the gene: LotjaGi2g1v0064900
GO terms
4
LotjaGi2g1v0064900.4
– DNA gyrase subunit A; TAIR: AT3G10690.1 DNA GYRASE A; Swiss-Prot: sp|Q5YLB5|GYRA_NICBE DNA gyrase subunit A, chloroplastic/mitochondrial; TrEMBL-Plants: tr|G7I9Z9|G7I9Z9_MEDTR DNA gyrase subunit A; Found in the gene: LotjaGi2g1v0064900
GO terms
4
LotjaGi5g1v0067100.1
– DNA topoisomerase family protein; TAIR: AT4G31210.1 DNA topoisomerase, type IA, core; Swiss-Prot: sp|Q4UM42|TOP1_RICFE DNA topoisomerase 1; TrEMBL-Plants: tr|K7M6M6|K7M6M6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0067100
GO terms
4
LotjaGi5g1v0067100.2
– DNA topoisomerase family protein; TAIR: AT4G31210.1 DNA topoisomerase, type IA, core; Swiss-Prot: sp|Q4UM42|TOP1_RICFE DNA topoisomerase 1; TrEMBL-Plants: tr|K7M6M6|K7M6M6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0067100
GO terms
4
LotjaGi6g1v0103100.1
– DNA topoisomerase; TAIR: AT2G32000.1 DNA topoisomerase, type IA, core; Swiss-Prot: sp|F4ISQ7|TOP3B_ARATH DNA topoisomerase 3-beta; TrEMBL-Plants: tr|I1LN46|I1LN46_SOYBN DNA topoisomerase; Found in the gene: LotjaGi6g1v0103100
GO terms
3
LotjaGi6g1v0103100.2
– DNA topoisomerase; TAIR: AT2G32000.2 DNA topoisomerase, type IA, core; Swiss-Prot: sp|F4ISQ7|TOP3B_ARATH DNA topoisomerase 3-beta; TrEMBL-Plants: tr|A0A0R0HWC7|A0A0R0HWC7_SOYBN DNA topoisomerase; Found in the gene: LotjaGi6g1v0103100
GO terms
3
LotjaGi6g1v0103100.3
– DNA topoisomerase; TAIR: AT2G32000.1 DNA topoisomerase, type IA, core; Swiss-Prot: sp|F4ISQ7|TOP3B_ARATH DNA topoisomerase 3-beta; TrEMBL-Plants: tr|I1LN46|I1LN46_SOYBN DNA topoisomerase; Found in the gene: LotjaGi6g1v0103100
GO terms
3
LotjaGi6g1v0103100.4
– DNA topoisomerase; TAIR: AT2G32000.1 DNA topoisomerase, type IA, core; Swiss-Prot: sp|F4ISQ7|TOP3B_ARATH DNA topoisomerase 3-beta; TrEMBL-Plants: tr|I1LN46|I1LN46_SOYBN DNA topoisomerase; Found in the gene: LotjaGi6g1v0103100
GO terms
3
LotjaGi6g1v0103100.5
– DNA topoisomerase; TAIR: AT2G32000.1 DNA topoisomerase, type IA, core; Swiss-Prot: sp|F4ISQ7|TOP3B_ARATH DNA topoisomerase 3-beta; TrEMBL-Plants: tr|I1LN46|I1LN46_SOYBN DNA topoisomerase; Found in the gene: LotjaGi6g1v0103100
GO terms
3

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0006265
Biological process DNA topological change 1 5.56