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GO:0070481

View this GO term in other databases

Overview

Field Value
Namespace Biological process
Short description Nuclear-transcribed mRNA catabolic process, non-stop decay
Full defintion The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that is lacking a stop codon.
Subterm of

Relationships

The relationship of GO:0070481 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
PMID
Exosome-mediated recognition and degradation of mRNAs lacking a termination codon.van Hoof A, Frischmeyer PA, Dietz HC, Parker R
Science. 2002 Mar 22; 295 (5563): 2262–4.PMID: 11910110

One role of messenger RNA (mRNA) degradation is to maintain the fidelity of gene expression by degrading aberrant transcripts. Recent results show that mRNAs without translation termination codons are unstable in eukaryotic cells. We used yeast mutants to demonstrate that these "nonstop" mRNAs are degraded by the exosome in a 3'-to-5' direction. The degradation of nonstop transcripts requires the exosome-associated protein Ski7p. Ski7p is closely related to the translation elongation factor EF1A and the translation termination factor eRF3. This suggests that the recognition of nonstop mRNAs involves the binding of Ski7p to an empty aminoacyl-(RNA-binding) site (A site) on the ribosome, thereby bringing the exosome to a mRNA with a ribosome stalled near the 3' end. This system efficiently degrades mRNAs that are prematurely polyadenylated within the coding region and prevents their expression.

Associated Lotus transcripts 6

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj1g3v4691650.1
– Pelota-like protein [Medicago truncatula] gi|357510895|ref|XP_003625736.1|
GO terms
3
Lj5g3v1301220.1
– PREDICTED: protein pelota-like [Glycine max] gi|356535240|ref|XP_003536156.1|
GO terms
3
LotjaGi1g1v0683200.1
– Protein pelota homolog; TAIR: AT4G27650.1 Eukaryotic release factor 1 (eRF1) family protein; Swiss-Prot: sp|Q9ZT87|PEL1_ARATH Protein PELOTA 1; TrEMBL-Plants: tr|G7L4Y7|G7L4Y7_MEDTR Eukaryotic release factor 1 (ERF1) family protein; Found in the gene: LotjaGi1g1v0683200
GO terms
3
LotjaGi5g1v0204100.1
– Protein pelota homolog; TAIR: AT4G27650.1 Eukaryotic release factor 1 (eRF1) family protein; Swiss-Prot: sp|Q9ZT87|PEL1_ARATH Protein PELOTA 1; TrEMBL-Plants: tr|V7BDS6|V7BDS6_PHAVU Protein pelota homolog; Found in the gene: LotjaGi5g1v0204100
GO terms
3
LotjaGi5g1v0204100.2
– Protein pelota homolog; TAIR: AT4G27650.1 Eukaryotic release factor 1 (eRF1) family protein; Swiss-Prot: sp|Q9ZT87|PEL1_ARATH Protein PELOTA 1; TrEMBL-Plants: tr|A0A151U5G2|A0A151U5G2_CAJCA Protein pelota homolog; Found in the gene: LotjaGi5g1v0204100
GO terms
3
LotjaGi5g1v0204100.3
– Protein pelota homolog; TAIR: AT4G27650.1 Eukaryotic release factor 1 (eRF1) family protein; Swiss-Prot: sp|Q9ZT87|PEL1_ARATH Protein PELOTA 1; TrEMBL-Plants: tr|A0A151U5G2|A0A151U5G2_CAJCA Protein pelota homolog; Found in the gene: LotjaGi5g1v0204100
GO terms
3

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0071025
Biological process RNA surveillance 1 16.67