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GO:0070966

View this GO term in other databases

Overview

Field Value
Namespace Biological process
Short description Nuclear-transcribed mRNA catabolic process, no-go decay
Full defintion The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA with stalls in translation elongation.
Subterm of

Relationships

The relationship of GO:0070966 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCjp
PMID
Endonucleolytic cleavage of eukaryotic mRNAs with stalls in translation elongation.Doma MK, Parker R
Nature. 2006 Mar 23; 440 (7083): 561–4.PMID: 16554824

A fundamental aspect of the biogenesis and function of eukaryotic messenger RNA is the quality control systems that recognize and degrade non-functional mRNAs. Eukaryotic mRNAs where translation termination occurs too soon (nonsense-mediated decay) or fails to occur (non-stop decay) are rapidly degraded. We show that yeast mRNAs with stalls in translation elongation are recognized and targeted for endonucleolytic cleavage, referred to as 'no-go decay'. The cleavage triggered by no-go decay is dependent on translation and involves Dom34p and Hbs1p. Dom34p and Hbs1p are similar to the translation termination factors eRF1 and eRF3 (refs 3, 4), indicating that these proteins might function in recognizing the stalled ribosome and triggering endonucleolytic cleavage. No-go decay provides a mechanism for clearing the cell of stalled translation elongation complexes, which could occur as a result of damaged mRNAs or ribosomes, or as a mechanism of post-transcriptional control.

Associated Lotus transcripts 6

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj1g3v4691650.1
– Pelota-like protein [Medicago truncatula] gi|357510895|ref|XP_003625736.1|
GO terms
3
Lj5g3v1301220.1
– PREDICTED: protein pelota-like [Glycine max] gi|356535240|ref|XP_003536156.1|
GO terms
3
LotjaGi1g1v0683200.1
– Protein pelota homolog; TAIR: AT4G27650.1 Eukaryotic release factor 1 (eRF1) family protein; Swiss-Prot: sp|Q9ZT87|PEL1_ARATH Protein PELOTA 1; TrEMBL-Plants: tr|G7L4Y7|G7L4Y7_MEDTR Eukaryotic release factor 1 (ERF1) family protein; Found in the gene: LotjaGi1g1v0683200
GO terms
3
LotjaGi5g1v0204100.1
– Protein pelota homolog; TAIR: AT4G27650.1 Eukaryotic release factor 1 (eRF1) family protein; Swiss-Prot: sp|Q9ZT87|PEL1_ARATH Protein PELOTA 1; TrEMBL-Plants: tr|V7BDS6|V7BDS6_PHAVU Protein pelota homolog; Found in the gene: LotjaGi5g1v0204100
GO terms
3
LotjaGi5g1v0204100.2
– Protein pelota homolog; TAIR: AT4G27650.1 Eukaryotic release factor 1 (eRF1) family protein; Swiss-Prot: sp|Q9ZT87|PEL1_ARATH Protein PELOTA 1; TrEMBL-Plants: tr|A0A151U5G2|A0A151U5G2_CAJCA Protein pelota homolog; Found in the gene: LotjaGi5g1v0204100
GO terms
3
LotjaGi5g1v0204100.3
– Protein pelota homolog; TAIR: AT4G27650.1 Eukaryotic release factor 1 (eRF1) family protein; Swiss-Prot: sp|Q9ZT87|PEL1_ARATH Protein PELOTA 1; TrEMBL-Plants: tr|A0A151U5G2|A0A151U5G2_CAJCA Protein pelota homolog; Found in the gene: LotjaGi5g1v0204100
GO terms
3

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0071025
Biological process RNA surveillance 1 16.67