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IPR000541 is a Cytoplasmic tRNA 2-thiolation protein 1.
<p>Cytoplasmic tRNA 2-thiolation protein 1 (also known as Ncs6/Tuc1 in budding yeasts) is responsible for 2-thiolation of mcm5S2U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln) [[cite:PUB00069585], [cite:PUB00045305]]. It directly binds tRNAs and probably acts by catalysing adenylation of tRNAs, an intermediate required for 2-thiolation. Its fission yeast homologue, Ctu1 forms a complex with Ctu2 (Ncs2/Tuc2 homologue) and serves as a putative enzyme for the formation of 2-thiouridine [[cite:PUB00069587]]. This family also includes tRNA-5-methyluridine(54) 2-sulfurtransferase, which catalyses the 2-thiolation of 5-methyluridine residue at position 54 in the T loop of tRNAs, leading to 5-methyl-2-thiouridine [[cite:PUB00087328]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | TRNA binding | Interacting selectively and non-covalently with transfer RNA. | ||
| Biological process | TRNA wobble uridine modification | The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified. | ||
| Biological process | TRNA thio-modification | The addition a sulfur atom to a nucleotide in a tRNA molecule. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Cytoplasmic tRNA 2-thiolation protein [Medicago truncatula] gi|357467587|ref|XP_003604078.1| | 15 | ||
| – | Cytoplasmic tRNA 2-thiolation protein; TAIR: AT2G44270.1 repressor of lrx1; Swiss-Prot: sp|O64862|CTU1_ARATH Cytoplasmic tRNA 2-thiolation protein 1; TrEMBL-Plants: tr|G7J985|G7J985_MEDTR Cytoplasmic tRNA 2-thiolation protein 1; Found in the gene: LotjaGi1g1v0556900 | 16 | ||
| – | Cytoplasmic tRNA 2-thiolation protein; TAIR: AT2G44270.1 repressor of lrx1; Swiss-Prot: sp|O64862|CTU1_ARATH Cytoplasmic tRNA 2-thiolation protein 1; TrEMBL-Plants: tr|V7AXH9|V7AXH9_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0556900 | 14 | ||
| – | Cytoplasmic tRNA 2-thiolation protein; TAIR: AT2G44270.1 repressor of lrx1; Swiss-Prot: sp|O64862|CTU1_ARATH Cytoplasmic tRNA 2-thiolation protein 1; TrEMBL-Plants: tr|G7J985|G7J985_MEDTR Cytoplasmic tRNA 2-thiolation protein 1; Found in the gene: LotjaGi1g1v0556900 | 15 | ||
| – | Cytoplasmic tRNA 2-thiolation protein; TAIR: AT2G44270.1 repressor of lrx1; Swiss-Prot: sp|O64862|CTU1_ARATH Cytoplasmic tRNA 2-thiolation protein 1; TrEMBL-Plants: tr|G7J985|G7J985_MEDTR Cytoplasmic tRNA 2-thiolation protein 1; Found in the gene: LotjaGi1g1v0556900 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |