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IPR000569

Source: InterPro

Description

IPR000569 is a HECT domain.

<p>The HECT (Homologous to the E6-AP Carboxyl Terminus) domain is an around 350 amino acids motif that has been identified in proteins that all belong to a particular E3 ubiquitin-protein ligase family [[cite:PUB00004858]]. HECT domain containing proteins accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then transfer it to lysine side chains of target proteins, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains. The site of ubiquitin thioester formation is a conserved cysteine residue located in the last 32-36 aa of the HECT domain [[cite:PUB00004858]]. The amino-terminal part of the HECT domain has been involved in E2 binding [[cite:PUB00018224], [cite:PUB00081573]]. Once linked to ubiquitin, the target proteins are degraded in the 26 S proteasome.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004842
Molecular function Ubiquitin-protein transferase activity Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
Subterm of

Associated Lotus transcripts 48

Transcript Name Description Predicted domains Domain count
Lj0g3v0111449.1
– PREDICTED: E3 ubiquitin-protein ligase UPL5-like [Glycine max] gi|356562613|ref|XP_003549564.1|
Domains
7
Lj0g3v0111459.1
– PREDICTED: E3 ubiquitin-protein ligase UPL5-like [Glycine max] gi|356562613|ref|XP_003549564.1|
Domains
17
Lj0g3v0204499.1
– E3 ubiquitin-protein ligase UPL5 [Medicago truncatula] gi|357447899|ref|XP_003594225.1|
Domains
7
Lj0g3v0269409.1
– PREDICTED: E3 ubiquitin-protein ligase UPL6-like [Cicer arietinum] gi|502080308|ref|XP_004486523.1|
Domains
8
Lj0g3v0269409.2
– PREDICTED: E3 ubiquitin-protein ligase UPL6-like [Cicer arietinum] gi|502080308|ref|XP_004486523.1|
Domains
6
Lj0g3v0358289.1
– PREDICTED: E3 ubiquitin-protein ligase UPL5-like [Glycine max] gi|356520102|ref|XP_003528704.1|
Domains
16
Lj1g3v0180970.1
– PREDICTED: E3 ubiquitin-protein ligase UPL2-like [Glycine max] gi|356551781|ref|XP_003544252.1|
Domains
33
Lj1g3v1526280.1
– PREDICTED: E3 ubiquitin-protein ligase UPL1-like [Glycine max] gi|356518443|ref|XP_003527888.1|
Domains
31
Lj1g3v3332720.1
– PREDICTED: E3 ubiquitin-protein ligase UPL3-like [Glycine max] gi|356507840|ref|XP_003522671.1|
Domains
12
Lj3g3v2737500.1
– PREDICTED: E3 ubiquitin-protein ligase UPL4-like isoform X1 [Cicer arietinum] gi|502121836|ref|XP_004497459.1|
Domains
6
Lj3g3v3464500.1
– PREDICTED: E3 ubiquitin-protein ligase UPL3-like [Glycine max] gi|356544882|ref|XP_003540876.1|
Domains
20
Lj4g3v0120060.1
– PREDICTED: E3 ubiquitin-protein ligase UPL5-like [Glycine max] gi|356562613|ref|XP_003549564.1|
Domains
19
Lj4g3v0217750.2
– PREDICTED: E3 ubiquitin-protein ligase UPL1-like [Glycine max] gi|356512215|ref|XP_003524816.1|
Domains
10
Lj4g3v1212350.1
– PREDICTED: E3 ubiquitin-protein ligase UPL3-like [Fragaria vesca subsp]. vesca] gi|470107059|ref|XP_004289868.1|
Domains
6
Lj5g3v0616290.1
– PREDICTED: E3 ubiquitin-protein ligase UPL4-like [Glycine max] gi|356545963|ref|XP_003541402.1|
Domains
9
Lj6g3v0367990.1
– PREDICTED: E3 ubiquitin-protein ligase UPL4-like [Fragaria vesca subsp]. vesca] gi|470141008|ref|XP_004306227.1|
Domains
6
Lj6g3v1160780.1
– PREDICTED: E3 ubiquitin-protein ligase UPL5-like [Glycine max] gi|356562613|ref|XP_003549564.1|
Domains
7
Lj6g3v1160790.1
– PREDICTED: E3 ubiquitin-protein ligase UPL5-like [Glycine max] gi|356520102|ref|XP_003528704.1|
Domains
14
Lj6g3v1754520.1
– PREDICTED: E3 ubiquitin-protein ligase UPL5-like [Glycine max] gi|356562613|ref|XP_003549564.1|
Domains
16
LotjaGi1g1v0135300.1
– E3 ubiquitin-protein ligase; TAIR: AT1G55860.1 LOW protein: E3 ubiquitin ligase-like protein; Swiss-Prot: sp|Q8GY23|UPL1_ARATH E3 ubiquitin-protein ligase UPL1; TrEMBL-Plants: tr|I1MB15|I1MB15_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0135300
Domains
34
LotjaGi1g1v0135300.2
– E3 ubiquitin-protein ligase; TAIR: AT1G55860.1 LOW protein: E3 ubiquitin ligase-like protein; Swiss-Prot: sp|Q8GY23|UPL1_ARATH E3 ubiquitin-protein ligase UPL1; TrEMBL-Plants: tr|K7M7U0|K7M7U0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0135300
Domains
32
LotjaGi1g1v0135300.3
– E3 ubiquitin-protein ligase; TAIR: AT1G55860.1 LOW protein: E3 ubiquitin ligase-like protein; Swiss-Prot: sp|Q8GY23|UPL1_ARATH E3 ubiquitin-protein ligase UPL1; TrEMBL-Plants: tr|I1MB15|I1MB15_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0135300
Domains
34
LotjaGi1g1v0135300.4
– E3 ubiquitin-protein ligase; TAIR: AT1G55860.1 LOW protein: E3 ubiquitin ligase-like protein; Swiss-Prot: sp|Q8GY23|UPL1_ARATH E3 ubiquitin-protein ligase UPL1; TrEMBL-Plants: tr|K7M7U0|K7M7U0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0135300
Domains
32
LotjaGi1g1v0135300.5
– E3 ubiquitin-protein ligase; TAIR: AT1G55860.1 LOW protein: E3 ubiquitin ligase-like protein; Swiss-Prot: sp|Q8GY23|UPL1_ARATH E3 ubiquitin-protein ligase UPL1; TrEMBL-Plants: tr|I1MB15|I1MB15_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0135300
Domains
34
LotjaGi1g1v0342400.1
– E3 ubiquitin-protein ligase; TAIR: AT1G55860.1 LOW protein: E3 ubiquitin ligase-like protein; Swiss-Prot: sp|Q8GY23|UPL1_ARATH E3 ubiquitin-protein ligase UPL1; TrEMBL-Plants: tr|I1K9T4|I1K9T4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0342400
Domains
34
LotjaGi1g1v0342400.2
– E3 ubiquitin-protein ligase; TAIR: AT1G55860.1 LOW protein: E3 ubiquitin ligase-like protein; Swiss-Prot: sp|Q8GY23|UPL1_ARATH E3 ubiquitin-protein ligase UPL1; TrEMBL-Plants: tr|I1K9T4|I1K9T4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0342400
Domains
34
LotjaGi1g1v0342400.3
– E3 ubiquitin-protein ligase; TAIR: AT1G55860.1 LOW protein: E3 ubiquitin ligase-like protein; Swiss-Prot: sp|Q8GY23|UPL1_ARATH E3 ubiquitin-protein ligase UPL1; TrEMBL-Plants: tr|I1K9T4|I1K9T4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0342400
Domains
34
LotjaGi1g1v0559300.1
– E3 ubiquitin-protein ligase; TAIR: AT4G38600.1 HECT ubiquitin protein ligase family protein KAK; Swiss-Prot: sp|Q6WWW4|UPL3_ARATH E3 ubiquitin-protein ligase UPL3; TrEMBL-Plants: tr|I1JSE2|I1JSE2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0559300
Domains
15
LotjaGi1g1v0682500.1
– E3 ubiquitin-protein ligase; TAIR: AT3G53090.1 ubiquitin-protein ligase 7; Swiss-Prot: sp|Q9SCQ2|UPL7_ARATH E3 ubiquitin-protein ligase UPL7; TrEMBL-Plants: tr|K7MZ55|K7MZ55_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0682500
Domains
16
LotjaGi1g1v0682500.2
– E3 ubiquitin-protein ligase; TAIR: AT3G53090.1 ubiquitin-protein ligase 7; Swiss-Prot: sp|Q9SCQ2|UPL7_ARATH E3 ubiquitin-protein ligase UPL7; TrEMBL-Plants: tr|A0A151TVC8|A0A151TVC8_CAJCA E3 ubiquitin-protein ligase UPL7; Found in the gene: LotjaGi1g1v0682500
Domains
16
LotjaGi3g1v0434700_LC.1
– E3 ubiquitin-protein ligase; TAIR: AT5G02880.1 ubiquitin-protein ligase 4; Swiss-Prot: sp|Q9LYZ7|UPL4_ARATH E3 ubiquitin-protein ligase UPL4; TrEMBL-Plants: tr|A0A067K9U6|A0A067K9U6_JATCU Uncharacterized protein; Found in the gene: LotjaGi3g1v0434700_LC
Domains
8
LotjaGi3g1v0521100.1
– E3 ubiquitin-protein ligase; TAIR: AT4G38600.1 HECT ubiquitin protein ligase family protein KAK; Swiss-Prot: sp|Q6WWW4|UPL3_ARATH E3 ubiquitin-protein ligase UPL3; TrEMBL-Plants: tr|I1LPS2|I1LPS2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0521100
Domains
21
LotjaGi3g1v0521100.2
– E3 ubiquitin-protein ligase; TAIR: AT4G38600.1 HECT ubiquitin protein ligase family protein KAK; Swiss-Prot: sp|Q6WWW4|UPL3_ARATH E3 ubiquitin-protein ligase UPL3; TrEMBL-Plants: tr|I1LPS2|I1LPS2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0521100
Domains
21
LotjaGi3g1v0521100.3
– E3 ubiquitin-protein ligase; TAIR: AT4G38600.1 HECT ubiquitin protein ligase family protein KAK; Swiss-Prot: sp|Q6WWW4|UPL3_ARATH E3 ubiquitin-protein ligase UPL3; TrEMBL-Plants: tr|I1LPS2|I1LPS2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0521100
Domains
21
LotjaGi3g1v0521100.4
– E3 ubiquitin-protein ligase; TAIR: AT4G38600.1 HECT ubiquitin protein ligase family protein KAK; Swiss-Prot: sp|Q6WWW4|UPL3_ARATH E3 ubiquitin-protein ligase UPL3; TrEMBL-Plants: tr|I1LPS2|I1LPS2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0521100
Domains
21
LotjaGi3g1v0521100.5
– E3 ubiquitin-protein ligase; TAIR: AT4G38600.1 HECT ubiquitin protein ligase family protein KAK; Swiss-Prot: sp|Q6WWW4|UPL3_ARATH E3 ubiquitin-protein ligase UPL3; TrEMBL-Plants: tr|I1LPS2|I1LPS2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0521100
Domains
20
LotjaGi3g1v0521100.6
– E3 ubiquitin-protein ligase; TAIR: AT4G38600.1 HECT ubiquitin protein ligase family protein KAK; Swiss-Prot: sp|Q6WWW4|UPL3_ARATH E3 ubiquitin-protein ligase UPL3; TrEMBL-Plants: tr|I1LPS2|I1LPS2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0521100
Domains
22
LotjaGi4g1v0008500.1
– E3 ubiquitin-protein ligase-like protein; TAIR: AT4G12570.1 ubiquitin protein ligase 5; Swiss-Prot: sp|Q9SU29|UPL5_ARATH E3 ubiquitin-protein ligase UPL5; TrEMBL-Plants: tr|K7MJB8|K7MJB8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0008500
Domains
23
LotjaGi4g1v0020600.1
– E3 ubiquitin-protein ligase; TAIR: AT1G55860.1 LOW protein: E3 ubiquitin ligase-like protein; Swiss-Prot: sp|Q8GY23|UPL1_ARATH E3 ubiquitin-protein ligase UPL1; TrEMBL-Plants: tr|I1K373|I1K373_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0020600
Domains
33
LotjaGi4g1v0020600.2
– E3 ubiquitin-protein ligase; TAIR: AT1G55860.1 LOW protein: E3 ubiquitin ligase-like protein; Swiss-Prot: sp|Q8GY23|UPL1_ARATH E3 ubiquitin-protein ligase UPL1; TrEMBL-Plants: tr|A0A0B2R0Y5|A0A0B2R0Y5_GLYSO E3 ubiquitin-protein ligase UPL1; Found in the gene: LotjaGi4g1v0020600
Domains
33
LotjaGi4g1v0020600.3
– E3 ubiquitin-protein ligase; TAIR: AT1G55860.1 LOW protein: E3 ubiquitin ligase-like protein; Swiss-Prot: sp|Q8GY23|UPL1_ARATH E3 ubiquitin-protein ligase UPL1; TrEMBL-Plants: tr|A0A0B2R0Y5|A0A0B2R0Y5_GLYSO E3 ubiquitin-protein ligase UPL1; Found in the gene: LotjaGi4g1v0020600
Domains
33
LotjaGi4g1v0162300.1
– E3 ubiquitin-protein ligase-like protein; TAIR: AT4G12570.1 ubiquitin protein ligase 5; Swiss-Prot: sp|Q9SU29|UPL5_ARATH E3 ubiquitin-protein ligase UPL5; TrEMBL-Plants: tr|K7MJB8|K7MJB8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0162300
Domains
18
LotjaGi5g1v0074600.1
– E3 ubiquitin-protein ligase; TAIR: AT5G02880.1 ubiquitin-protein ligase 4; Swiss-Prot: sp|Q9LYZ7|UPL4_ARATH E3 ubiquitin-protein ligase UPL4; TrEMBL-Plants: tr|K7LZL3|K7LZL3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0074600
Domains
17
LotjaGi6g1v0262400.1
– E3 ubiquitin-protein ligase; TAIR: AT3G17205.1 ubiquitin protein ligase 6; Swiss-Prot: sp|Q8RWB8|UPL6_ARATH E3 ubiquitin-protein ligase UPL6; TrEMBL-Plants: tr|V7BS42|V7BS42_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0262400
Domains
15
LotjaGi6g1v0262400.2
– E3 ubiquitin-protein ligase; TAIR: AT3G17205.1 ubiquitin protein ligase 6; Swiss-Prot: sp|Q8RWB8|UPL6_ARATH E3 ubiquitin-protein ligase UPL6; TrEMBL-Plants: tr|V7BS42|V7BS42_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0262400
Domains
15
LotjaGi6g1v0262400.3
– E3 ubiquitin-protein ligase; TAIR: AT3G17205.1 ubiquitin protein ligase 6; Swiss-Prot: sp|Q8RWB8|UPL6_ARATH E3 ubiquitin-protein ligase UPL6; TrEMBL-Plants: tr|V7BS42|V7BS42_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0262400
Domains
15
LotjaGi6g1v0286600_LC.1
– E3 ubiquitin-protein ligase-like protein; TAIR: AT4G12570.1 ubiquitin protein ligase 5; Swiss-Prot: sp|Q9SU29|UPL5_ARATH E3 ubiquitin-protein ligase UPL5; TrEMBL-Plants: tr|A0A151SU57|A0A151SU57_CAJCA E3 ubiquitin-protein ligase UPL5; Found in the gene: LotjaGi6g1v0286600_LC
Domains
10
LotjaGi6g1v0286700.1
– E3 ubiquitin-protein ligase-like protein; TAIR: AT4G12570.1 ubiquitin protein ligase 5; Swiss-Prot: sp|Q9SU29|UPL5_ARATH E3 ubiquitin-protein ligase UPL5; TrEMBL-Plants: tr|K7L3Y8|K7L3Y8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0286700
Domains
21

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd16107 CDD 1 2.08