Description

IPR003903 is a Ubiquitin interacting motif.

<p>The Ubiquitin Interacting Motif (UIM), or 'LALAL-motif', is a stretch of about 20 amino acid residues, which was first described in the 26S proteasome subunit PSD4/RPN-10 that is known to recognise ubiquitin [[cite:PUB00007601], [cite:PUB00018255]]. In addition, the UIM is found, often in tandem or triplet arrays, in a variety of proteins either involved in ubiquitination and ubiquitin metabolism, or known to interact with ubiquitin-like modifiers. Among the UIM proteins are two different subgroups of the UBP (ubiquitin carboxy-terminal hydrolase) family of deubiquitinating enzymes, one F-box protein, one family of HECT-containing ubiquitin-ligases (E3s) from plants, and several proteins containing ubiquitin-associated UBA and/or UBX domains [[cite:PUB00018086]]. In most of these proteins, the UIM occurs in multiple copies and in association with other domains such as UBA ([interpro:IPR015940]), UBX ([interpro:IPR001012]), ENTH, EH ([interpro:IPR000261]), VHS ([interpro:IPR002014]), SH3 ([interpro:IPR001452]), HECT ([interpro:IPR000569]), VWFA ([interpro:IPR002035]), EF-hand calcium-binding, WD-40 ([interpro:IPR001680]), F-box ([interpro:IPR001810]), LIM ([interpro:IPR001781]), protein kinase ([interpro:IPR000719]), ankyrin ([interpro:IPR002110]), PX ([interpro:IPR001683]), phosphatidylinositol 3- and 4-kinase ([interpro:IPR000403]), C2 ([interpro:IPR000008]), OTU ([interpro:IPR003323]), dnaJ ([interpro:IPR001623]), RING-finger ([interpro:IPR001841]) or FYVE-finger ([interpro:IPR017455]). UIMs have been shown to bind ubiquitin and to serve as a specific targeting signal important for monoubiquitination. Thus, UIMs may have several functions in ubiquitin metabolism each of which may require different numbers of UIMs [[cite:PUB00018256], [cite:PUB00018257], [cite:PUB00044081]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 41

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: