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IPR002108 is a Actin-depolymerising factor homology domain.
<p>The actin-depolymerising factor homology (ADF-H) domain is an ~150-amino acid motif that is present in three phylogenetically distinct classes of eukaryotic actin-binding proteins [[cite:PUB00043718], [cite:PUB00022142], [cite:PUB00043719]]:</p> <ul> <li>ADF/cofilins, which include ADF, cofilin, destrin, actophorin, coactosin, depactin and glia maturation factors (GMFs) beta and gamma. ADF/cofilins are small actin-binding proteins composed of a single ADF-H domain. They bind both actin-monomers and filaments and promote rapid filament turnover in cells by depolymerising/fragmenting actin filaments. ADF/cofilins bind ADP-actin with higher affinity than ATP-actin and inhibit the spontaneous nucleotide exchange on actin monomers</li> <li>Twinfilins, which are actin monomer-binding proteins that are composed of two ADF-H domains</li> <li>Abp1/Drebrins, which are relatively large proteins composed of an N-terminal ADF-H domain followed by a variable region and a C-terminal SH3 domain. Abp1/Drebrins interact only with actin filaments and do not promote filament depolymerisation or fragmentation</li> </ul> <p>Although these proteins are biochemically distinct and play different roles in actin dynamics, they all appear to use the ADF-H domain for their interactions with actin.</p> <p>The ADF-H domain consists of a six-stranded mixed β-sheet in which the four central strands (β2-β5) are antiparallel and the two edge strands (β1 and β6) run parallel with the neighbouring strands. The sheet is surrounded by two α-helices on each side [[cite:PUB00043718], [cite:PUB00022142], [cite:PUB00031293]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Actin binding | Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Actin depolymerizing factor [Medicago truncatula] gi|357481641|ref|XP_003611106.1| | 9 | ||
| – | PREDICTED: actin-depolymerizing factor 6-like [Glycine max] gi|356518048|ref|XP_003527696.1| | 11 | ||
| – | PREDICTED: actin-depolymerizing factor-like [Cicer arietinum] gi|502109989|ref|XP_004493773.1| | 11 | ||
| – | PREDICTED: actin-depolymerizing factor 7-like [Glycine max] gi|356539756|ref|XP_003538360.1| | 11 | ||
| – | PREDICTED: actin-depolymerizing factor 2-like [Glycine max] gi|356532954|ref|XP_003535034.1| | 9 | ||
| – | Actin depolymerizing factor-like protein [Medicago truncatula] gi|357519237|ref|XP_003629907.1| | 11 | ||
| – | PREDICTED: actin-depolymerizing factor 2-like [Cicer arietinum] gi|502114657|ref|XP_004495011.1| | 11 | ||
| – | PREDICTED: actin-depolymerizing factor 7-like [Cicer arietinum] gi|502119278|ref|XP_004496563.1| | 11 | ||
| – | Actin-depolymerizing factor; TAIR: AT2G31200.1 actin depolymerizing factor 6; Swiss-Prot: sp|Q8SAG3|ADF_VITVI Actin-depolymerizing factor; TrEMBL-Plants: tr|I3S1M0|I3S1M0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0709700 | 11 | ||
| – | Actin-depolymerizing factor; TAIR: AT2G31200.1 actin depolymerizing factor 6; Swiss-Prot: sp|Q8SAG3|ADF_VITVI Actin-depolymerizing factor; TrEMBL-Plants: tr|I3S1M0|I3S1M0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0709700 | 11 | ||
| – | Actin depolymerizing factor, putative; TAIR: AT4G25590.1 actin depolymerizing factor 7; Swiss-Prot: sp|Q67ZM4|ADF7_ARATH Actin-depolymerizing factor 7; TrEMBL-Plants: tr|I3S6E4|I3S6E4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0433100 | 11 | ||
| – | Actin depolymerizing factor, putative; TAIR: AT4G25590.1 actin depolymerizing factor 7; Swiss-Prot: sp|Q67ZM4|ADF7_ARATH Actin-depolymerizing factor 7; TrEMBL-Plants: tr|I3S6E4|I3S6E4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0433100 | 11 | ||
| – | Actin-depolymerizing factor; TAIR: AT2G16700.1 actin depolymerizing factor 5; Swiss-Prot: sp|Q9ZNT3|ADF5_ARATH Actin-depolymerizing factor 5; TrEMBL-Plants: tr|I3S730|I3S730_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0521900 | 14 | ||
| – | Actin-depolymerizing factor; TAIR: AT2G16700.1 actin depolymerizing factor 5; Swiss-Prot: sp|Q9ZNT3|ADF5_ARATH Actin-depolymerizing factor 5; TrEMBL-Plants: tr|I3S730|I3S730_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0521900 | 11 | ||
| – | Actin depolymerizing factor-like protein; TAIR: AT3G46010.1 actin depolymerizing factor 1; Swiss-Prot: sp|Q39250|ADF1_ARATH Actin-depolymerizing factor 1; TrEMBL-Plants: tr|I3SQ66|I3SQ66_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0384300 | 11 | ||
| – | Actin depolymerizing factor-like protein; TAIR: AT3G46010.1 actin depolymerizing factor 1; Swiss-Prot: sp|Q39250|ADF1_ARATH Actin-depolymerizing factor 1; TrEMBL-Plants: tr|I3SQ66|I3SQ66_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0384300 | 11 | ||
| – | Actin depolymerizing factor-like protein; TAIR: AT3G46010.1 actin depolymerizing factor 1; Swiss-Prot: sp|Q39250|ADF1_ARATH Actin-depolymerizing factor 1; TrEMBL-Plants: tr|I3SQ66|I3SQ66_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0384300 | 11 | ||
| – | Actin depolymerizing factor-like protein; TAIR: AT3G46010.1 actin depolymerizing factor 1; Swiss-Prot: sp|Q39250|ADF1_ARATH Actin-depolymerizing factor 1; TrEMBL-Plants: tr|I3SQ66|I3SQ66_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0384300 | 11 | ||
| – | Actin depolymerizing factor, putative; TAIR: AT4G25590.1 actin depolymerizing factor 7; Swiss-Prot: sp|Q67ZM4|ADF7_ARATH Actin-depolymerizing factor 7; TrEMBL-Plants: tr|I3T7V9|I3T7V9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0424900 | 15 | ||
| – | Actin depolymerizing factor, putative; TAIR: AT4G25590.1 actin depolymerizing factor 7; Swiss-Prot: sp|Q67ZM4|ADF7_ARATH Actin-depolymerizing factor 7; TrEMBL-Plants: tr|I3T7V9|I3T7V9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0424900 | 11 | ||
| – | Actin depolymerizing factor, putative; TAIR: AT4G25590.1 actin depolymerizing factor 7; Swiss-Prot: sp|Q67ZM4|ADF7_ARATH Actin-depolymerizing factor 7; TrEMBL-Plants: tr|I3T7V9|I3T7V9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0424900 | 11 | ||
| – | Actin depolymerizing factor, putative; TAIR: AT4G25590.1 actin depolymerizing factor 7; Swiss-Prot: sp|Q67ZM4|ADF7_ARATH Actin-depolymerizing factor 7; TrEMBL-Plants: tr|I3T7V9|I3T7V9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0424900 | 11 | ||
| – | Actin-depolymerizing factor; TAIR: AT5G59890.1 actin depolymerizing factor 4; Swiss-Prot: sp|Q9FVI1|ADF2_PETHY Actin-depolymerizing factor 2; TrEMBL-Plants: tr|I3T8B9|I3T8B9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0068400 | 11 | ||
| – | Actin-depolymerizing factor; TAIR: AT5G59890.1 actin depolymerizing factor 4; Swiss-Prot: sp|Q9FVI1|ADF2_PETHY Actin-depolymerizing factor 2; TrEMBL-Plants: tr|I3T8B9|I3T8B9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0068400 | 11 | ||
| – | Actin-depolymerizing factor; TAIR: AT5G59890.1 actin depolymerizing factor 4; Swiss-Prot: sp|Q9FVI1|ADF2_PETHY Actin-depolymerizing factor 2; TrEMBL-Plants: tr|I3T8B9|I3T8B9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0068400 | 11 | ||
| – | Actin-depolymerizing factor; TAIR: AT5G59890.1 actin depolymerizing factor 4; Swiss-Prot: sp|Q9FVI1|ADF2_PETHY Actin-depolymerizing factor 2; TrEMBL-Plants: tr|I3T8B9|I3T8B9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0068400 | 11 | ||
| – | Actin-depolymerizing factor; TAIR: AT2G31200.1 actin depolymerizing factor 6; Swiss-Prot: sp|Q9ZSK2|ADF6_ARATH Actin-depolymerizing factor 6; TrEMBL-Plants: tr|I3SVU5|I3SVU5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0191100 | 11 | ||
| – | Actin-depolymerizing factor; TAIR: AT2G31200.1 actin depolymerizing factor 6; Swiss-Prot: sp|Q9ZSK2|ADF6_ARATH Actin-depolymerizing factor 6; TrEMBL-Plants: tr|I3SVU5|I3SVU5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0191100 | 11 | ||
| – | Actin-depolymerizing factor family protein; TAIR: AT4G25590.1 actin depolymerizing factor 7; Swiss-Prot: sp|Q67ZM4|ADF7_ARATH Actin-depolymerizing factor 7; TrEMBL-Plants: tr|B9I489|B9I489_POPTR Actin-depolymerizing factor family protein; Found in the gene: LotjaGi5g1v0300500 | 11 | ||
| – | Actin-depolymerizing factor family protein; TAIR: AT4G25590.1 actin depolymerizing factor 7; Swiss-Prot: sp|Q67ZM4|ADF7_ARATH Actin-depolymerizing factor 7; TrEMBL-Plants: tr|B9I489|B9I489_POPTR Actin-depolymerizing factor family protein; Found in the gene: LotjaGi5g1v0300500 | 11 | ||
| – | Actin depolymerizing factor-like protein; TAIR: AT5G59880.1 actin depolymerizing factor 3; Swiss-Prot: sp|Q9FVI1|ADF2_PETHY Actin-depolymerizing factor 2; TrEMBL-Plants: tr|I3SI08|I3SI08_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0276800 | 11 | ||
| – | Actin depolymerizing factor-like protein; TAIR: AT5G59880.1 actin depolymerizing factor 3; Swiss-Prot: sp|Q9FVI1|ADF2_PETHY Actin-depolymerizing factor 2; TrEMBL-Plants: tr|I3SI08|I3SI08_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0276800 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd11286 | CDD | 1 | 3.13 |