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IPR017904 is a ADF/Cofilin.
<p>Actin depolymerization factor/cofilin-like domains (ADF domains) are present in a family of essential eukaryotic actin regulatory proteins. These proteins enhance the turnover rate of actin, and interact with actin monomers (G-actin) as well as actin filaments (F-actin), typically with a preference for ADP-G-actin subunits [[cite:PUB00080547], [cite:PUB00080548], [cite:PUB00080549]]. The basic function of cofilin is to promote disassembly of aged actin filaments. Vertebrates have three isoforms of cofilin: cofilin-1 (Cfl1, non-muscle cofilin), cofilin-2 (muscle cofilin), and ADF (destrin) [[cite:PUB00080546], [cite:PUB00080550]]. The modes of action of ADF/cofilins highly depend on their concentration. When ADF/cofilins are present in low concentrations they prefer to sever the actin filaments and promote the depolymerization of the pointed end of the filament. At high concentrations they can increase the polymerization by nucleating new actin filaments [[cite:PUB00041585]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. | ||
| Biological process | Actin filament depolymerization | Disassembly of actin filaments by the removal of actin monomers from a filament. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Actin depolymerizing factor [Medicago truncatula] gi|357481641|ref|XP_003611106.1| | 9 | ||
| – | PREDICTED: actin-depolymerizing factor 6-like [Glycine max] gi|356518048|ref|XP_003527696.1| | 11 | ||
| – | PREDICTED: actin-depolymerizing factor-like [Cicer arietinum] gi|502109989|ref|XP_004493773.1| | 11 | ||
| – | PREDICTED: actin-depolymerizing factor 7-like [Glycine max] gi|356539756|ref|XP_003538360.1| | 11 | ||
| – | Actin depolymerizing factor 5 [Theobroma cacao] gi|508705807|gb|EOX97703.1| | 10 | ||
| – | PREDICTED: actin-depolymerizing factor 2-like [Glycine max] gi|356532954|ref|XP_003535034.1| | 9 | ||
| – | Actin depolymerizing factor-like protein [Medicago truncatula] gi|357519237|ref|XP_003629907.1| | 11 | ||
| – | PREDICTED: actin-depolymerizing factor 2-like [Cicer arietinum] gi|502114657|ref|XP_004495011.1| | 11 | ||
| – | PREDICTED: actin-depolymerizing factor 7-like [Cicer arietinum] gi|502119278|ref|XP_004496563.1| | 11 | ||
| – | Actin-depolymerizing factor; TAIR: AT2G31200.1 actin depolymerizing factor 6; Swiss-Prot: sp|Q8SAG3|ADF_VITVI Actin-depolymerizing factor; TrEMBL-Plants: tr|I3S1M0|I3S1M0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0709700 | 11 | ||
| – | Actin-depolymerizing factor; TAIR: AT2G31200.1 actin depolymerizing factor 6; Swiss-Prot: sp|Q8SAG3|ADF_VITVI Actin-depolymerizing factor; TrEMBL-Plants: tr|I3S1M0|I3S1M0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0709700 | 11 | ||
| – | Actin depolymerizing factor, putative; TAIR: AT4G25590.1 actin depolymerizing factor 7; Swiss-Prot: sp|Q67ZM4|ADF7_ARATH Actin-depolymerizing factor 7; TrEMBL-Plants: tr|I3S6E4|I3S6E4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0433100 | 11 | ||
| – | Actin depolymerizing factor, putative; TAIR: AT4G25590.1 actin depolymerizing factor 7; Swiss-Prot: sp|Q67ZM4|ADF7_ARATH Actin-depolymerizing factor 7; TrEMBL-Plants: tr|I3S6E4|I3S6E4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0433100 | 11 | ||
| – | Actin-depolymerizing factor; TAIR: AT2G16700.1 actin depolymerizing factor 5; Swiss-Prot: sp|Q9ZNT3|ADF5_ARATH Actin-depolymerizing factor 5; TrEMBL-Plants: tr|I3S730|I3S730_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0521900 | 14 | ||
| – | Actin-depolymerizing factor; TAIR: AT2G16700.1 actin depolymerizing factor 5; Swiss-Prot: sp|Q9ZNT3|ADF5_ARATH Actin-depolymerizing factor 5; TrEMBL-Plants: tr|I3S730|I3S730_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0521900 | 11 | ||
| – | Actin depolymerizing factor-like protein; TAIR: AT3G46010.1 actin depolymerizing factor 1; Swiss-Prot: sp|Q39250|ADF1_ARATH Actin-depolymerizing factor 1; TrEMBL-Plants: tr|I3SQ66|I3SQ66_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0384300 | 11 | ||
| – | Actin depolymerizing factor-like protein; TAIR: AT3G46010.1 actin depolymerizing factor 1; Swiss-Prot: sp|Q39250|ADF1_ARATH Actin-depolymerizing factor 1; TrEMBL-Plants: tr|I3SQ66|I3SQ66_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0384300 | 11 | ||
| – | Actin depolymerizing factor-like protein; TAIR: AT3G46010.1 actin depolymerizing factor 1; Swiss-Prot: sp|Q39250|ADF1_ARATH Actin-depolymerizing factor 1; TrEMBL-Plants: tr|I3SQ66|I3SQ66_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0384300 | 11 | ||
| – | Actin depolymerizing factor-like protein; TAIR: AT3G46010.1 actin depolymerizing factor 1; Swiss-Prot: sp|Q39250|ADF1_ARATH Actin-depolymerizing factor 1; TrEMBL-Plants: tr|I3SQ66|I3SQ66_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0384300 | 11 | ||
| – | Actin depolymerizing factor, putative; TAIR: AT4G25590.1 actin depolymerizing factor 7; Swiss-Prot: sp|Q67ZM4|ADF7_ARATH Actin-depolymerizing factor 7; TrEMBL-Plants: tr|I3T7V9|I3T7V9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0424900 | 15 | ||
| – | Actin depolymerizing factor, putative; TAIR: AT4G25590.1 actin depolymerizing factor 7; Swiss-Prot: sp|Q67ZM4|ADF7_ARATH Actin-depolymerizing factor 7; TrEMBL-Plants: tr|I3T7V9|I3T7V9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0424900 | 11 | ||
| – | Actin depolymerizing factor, putative; TAIR: AT4G25590.1 actin depolymerizing factor 7; Swiss-Prot: sp|Q67ZM4|ADF7_ARATH Actin-depolymerizing factor 7; TrEMBL-Plants: tr|I3T7V9|I3T7V9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0424900 | 11 | ||
| – | Actin depolymerizing factor, putative; TAIR: AT4G25590.1 actin depolymerizing factor 7; Swiss-Prot: sp|Q67ZM4|ADF7_ARATH Actin-depolymerizing factor 7; TrEMBL-Plants: tr|I3T7V9|I3T7V9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0424900 | 11 | ||
| – | Actin-depolymerizing factor; TAIR: AT5G59890.1 actin depolymerizing factor 4; Swiss-Prot: sp|Q9FVI1|ADF2_PETHY Actin-depolymerizing factor 2; TrEMBL-Plants: tr|I3T8B9|I3T8B9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0068400 | 11 | ||
| – | Actin-depolymerizing factor; TAIR: AT5G59890.1 actin depolymerizing factor 4; Swiss-Prot: sp|Q9FVI1|ADF2_PETHY Actin-depolymerizing factor 2; TrEMBL-Plants: tr|I3T8B9|I3T8B9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0068400 | 11 | ||
| – | Actin-depolymerizing factor; TAIR: AT5G59890.1 actin depolymerizing factor 4; Swiss-Prot: sp|Q9FVI1|ADF2_PETHY Actin-depolymerizing factor 2; TrEMBL-Plants: tr|I3T8B9|I3T8B9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0068400 | 11 | ||
| – | Actin-depolymerizing factor; TAIR: AT5G59890.1 actin depolymerizing factor 4; Swiss-Prot: sp|Q9FVI1|ADF2_PETHY Actin-depolymerizing factor 2; TrEMBL-Plants: tr|I3T8B9|I3T8B9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0068400 | 11 | ||
| – | Actin-depolymerizing factor; TAIR: AT2G31200.1 actin depolymerizing factor 6; Swiss-Prot: sp|Q9ZSK2|ADF6_ARATH Actin-depolymerizing factor 6; TrEMBL-Plants: tr|I3SVU5|I3SVU5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0191100 | 11 | ||
| – | Actin-depolymerizing factor; TAIR: AT2G31200.1 actin depolymerizing factor 6; Swiss-Prot: sp|Q9ZSK2|ADF6_ARATH Actin-depolymerizing factor 6; TrEMBL-Plants: tr|I3SVU5|I3SVU5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0191100 | 11 | ||
| – | Actin-depolymerizing factor family protein; TAIR: AT4G25590.1 actin depolymerizing factor 7; Swiss-Prot: sp|Q67ZM4|ADF7_ARATH Actin-depolymerizing factor 7; TrEMBL-Plants: tr|B9I489|B9I489_POPTR Actin-depolymerizing factor family protein; Found in the gene: LotjaGi5g1v0300500 | 11 | ||
| – | Actin-depolymerizing factor family protein; TAIR: AT4G25590.1 actin depolymerizing factor 7; Swiss-Prot: sp|Q67ZM4|ADF7_ARATH Actin-depolymerizing factor 7; TrEMBL-Plants: tr|B9I489|B9I489_POPTR Actin-depolymerizing factor family protein; Found in the gene: LotjaGi5g1v0300500 | 11 | ||
| – | Actin depolymerizing factor-like protein; TAIR: AT5G59880.1 actin depolymerizing factor 3; Swiss-Prot: sp|Q9FVI1|ADF2_PETHY Actin-depolymerizing factor 2; TrEMBL-Plants: tr|I3SI08|I3SI08_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0276800 | 11 | ||
| – | Actin depolymerizing factor-like protein; TAIR: AT5G59880.1 actin depolymerizing factor 3; Swiss-Prot: sp|Q9FVI1|ADF2_PETHY Actin-depolymerizing factor 2; TrEMBL-Plants: tr|I3SI08|I3SI08_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0276800 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd11286 | CDD | 1 | 3.03 |