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IPR002317 is a Serine-tRNA ligase, type1.
<p>Serine-tRNA ligase ([ec:6.1.1.11]) exists as monomer and belongs to the aminoacyl-tRNA synthetase class IIa [[cite:PUB00006326]]. It catalyses the attachment of serine to tRNA (Ser). It is also able to aminoacylate tRNA (Sec) with serine, to form the misacylated tRNA L-seryl-tRNA (Sec), which will be further converted into selenocysteinyl-tRNA (Sec).</p> <p>The aminoacyl-tRNA synthetases (also known as aminoacyl-tRNA ligases) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction [[cite:PUB00079872], [cite:PUB00079873]]. These proteins differ widely in size and oligomeric state, and have limited sequence homology [[cite:PUB00007191]]. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric [[cite:PUB00006477]]. Class II aminoacyl-tRNA synthetases share an anti-parallel β-sheet fold flanked by α-helices [[cite:PUB00000386]], and are mostly dimeric or multimeric, containing at least three conserved regions [[cite:PUB00000723], [cite:PUB00005365], [cite:PUB00004391]]. However, tRNA binding involves an α-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan, valine, and some lysine synthetases (non-eukaryotic group) belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, phenylalanine, proline, serine, threonine, and some lysine synthetases (non-archaeal group), belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c [[cite:PUB00007363]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Nucleotide binding | Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. | ||
| Molecular function | Serine-tRNA ligase activity | Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). | ||
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Biological process | Seryl-tRNA aminoacylation | The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Seryl-tRNA synthetase [Medicago truncatula] gi|357465107|ref|XP_003602835.1| | 17 | ||
| – | Seryl-tRNA synthetase [Medicago truncatula] gi|357465105|ref|XP_003602834.1| | 21 | ||
| – | PREDICTED: seryl-tRNA synthetase-like [Glycine max] gi|356576773|ref|XP_003556504.1| | 10 | ||
| – | PREDICTED: seryl-tRNA synthetase-like [Glycine max] gi|356576773|ref|XP_003556504.1| | 20 | ||
| – | PREDICTED: seryl-tRNA synthetase-like [Glycine max] gi|356576773|ref|XP_003556504.1| | 20 | ||
| – | Serine--tRNA ligase; TAIR: AT1G11870.2 Seryl-tRNA synthetase; Swiss-Prot: sp|Q8RWT8|SYSM_ARATH Serine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|G7J3Z0|G7J3Z0_MEDTR Seryl-tRNA synthetase/serine-tRNA ligase; Found in the gene: LotjaGi1g1v0339700 | 22 | ||
| – | Serine--tRNA ligase; TAIR: AT1G11870.1 Seryl-tRNA synthetase; Swiss-Prot: sp|Q8RWT8|SYSM_ARATH Serine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|G7J3Z0|G7J3Z0_MEDTR Seryl-tRNA synthetase/serine-tRNA ligase; Found in the gene: LotjaGi1g1v0339700 | 17 | ||
| – | Serine--tRNA ligase; TAIR: AT1G11870.1 Seryl-tRNA synthetase; Swiss-Prot: sp|Q8RWT8|SYSM_ARATH Serine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|G7J3Z0|G7J3Z0_MEDTR Seryl-tRNA synthetase/serine-tRNA ligase; Found in the gene: LotjaGi1g1v0339700 | 17 | ||
| – | Serine--tRNA ligase; TAIR: AT5G27470.1 seryl-tRNA synthetase / serine-tRNA ligase; Swiss-Prot: sp|O81983|SYS_HELAN Serine--tRNA ligase; TrEMBL-Plants: tr|A0A0B2Q4B0|A0A0B2Q4B0_GLYSO Serine--tRNA ligase; Found in the gene: LotjaGi5g1v0220300 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00770 | CDD | 1 | 11.11 |