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IPR015866 is a Serine-tRNA synthetase, type1, N-terminal.
<p>This entry represents the N-terminal domain of Serine-tRNA synthetase, which consists of two helices in a long α-hairpin and corresponds to the tRNA binding domain. Serine-tRNA synthetase ([ec:6.1.1.11]) exists as monomer and belongs to class IIa aminoacyl-tRNA synthetase [[cite:PUB00006326]].</p> <p>The aminoacyl-tRNA synthetases (also known as aminoacyl-tRNA ligases) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction [[cite:PUB00079872], [cite:PUB00079873]]. These proteins differ widely in size and oligomeric state, and have limited sequence homology [[cite:PUB00007191]]. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric [[cite:PUB00006477]]. Class II aminoacyl-tRNA synthetases share an anti-parallel β-sheet fold flanked by α-helices [[cite:PUB00000386]], and are mostly dimeric or multimeric, containing at least three conserved regions [[cite:PUB00000723], [cite:PUB00005365], [cite:PUB00004391]]. However, tRNA binding involves an α-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan, valine, and some lysine synthetases (non-eukaryotic group) belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, phenylalanine, proline, serine, threonine, and some lysine synthetases (non-archaeal group), belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c [[cite:PUB00007363]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Seryl-tRNA synthetase [Medicago truncatula] gi|357465105|ref|XP_003602834.1| | 21 | ||
| – | PREDICTED: B-cell receptor-associated protein 31-like [Cicer arietinum] gi|502145996|ref|XP_004506274.1| | 11 | ||
| – | PREDICTED: seryl-tRNA synthetase-like [Glycine max] gi|356576773|ref|XP_003556504.1| | 20 | ||
| – | PREDICTED: seryl-tRNA synthetase-like [Glycine max] gi|356576773|ref|XP_003556504.1| | 20 | ||
| – | PREDICTED: B-cell receptor-associated protein 29-like [Cicer arietinum] gi|502079163|ref|XP_004486174.1| | 11 | ||
| – | PREDICTED: B-cell receptor-associated protein 29-like [Cicer arietinum] gi|502079163|ref|XP_004486174.1| | 11 | ||
| – | Serine--tRNA ligase; TAIR: AT1G11870.2 Seryl-tRNA synthetase; Swiss-Prot: sp|Q8RWT8|SYSM_ARATH Serine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|G7J3Z0|G7J3Z0_MEDTR Seryl-tRNA synthetase/serine-tRNA ligase; Found in the gene: LotjaGi1g1v0339700 | 22 | ||
| – | Serine--tRNA ligase; TAIR: AT5G27470.1 seryl-tRNA synthetase / serine-tRNA ligase; Swiss-Prot: sp|O81983|SYS_HELAN Serine--tRNA ligase; TrEMBL-Plants: tr|A0A0B2Q4B0|A0A0B2Q4B0_GLYSO Serine--tRNA ligase; Found in the gene: LotjaGi5g1v0220300 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00770 | CDD | 1 | 12.50 |