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IPR002344 is a Lupus La protein.
<p>The La protein is a 47kDa polypeptide that often acts as an autoantigen in systemic lupus erythematosus and Sjogren's syndrome patients [[cite:PUB00014753]]. It occurs in both the nucleus and the cytoplasm, where it takes on different roles [[cite:PUB00014754]]. In the nucleus, La facilitates the production of tRNAs, acting as a RNA polymerase III (RNAP III) transcription factor by binding to the U-rich 3'UTR of nascent transcripts, assisting in their folding and maturation [[cite:PUB00014760]]. In the cytoplasm, La facilitates the translation of specific mRNAs, acting as a translation factor. As a RNA binding protein (RBP), La associates with subsets of mRNAs that contain a 5'-terminal oligopyrimidine (5'TOP) motif known to control protein synthesis. The binding of La to specific classes of RNA molecules regulates their downstream processing, protects them from endonuclease digestion, and organises their export from the nucleus [[cite:PUB00014755], [cite:PUB00014756], [cite:PUB00014757], [cite:PUB00014758]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | RNA binding | Interacting selectively and non-covalently with an RNA molecule or a portion thereof. | ||
| Cellular component | Nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. | ||
| Biological process | RNA processing | Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. | ||
| Cellular component | Ribonucleoprotein complex | A macromolecular complex containing both protein and RNA molecules. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: la-related protein 7-like [Cicer arietinum] gi|502078710|ref|XP_004486031.1| | 11 | ||
| – | PREDICTED: la-related protein 7-like [Cicer arietinum] gi|502124330|ref|XP_004498482.1| | 20 | ||
| – | PREDICTED: lupus La protein homolog A-like [Glycine max] gi|356515577|ref|XP_003526475.1| | 23 | ||
| – | PREDICTED: la-related protein 7-like [Cucumis sativus] gi|449492647|ref|XP_004159060.1| | 18 | ||
| – | La-related protein [Medicago truncatula] gi|357447339|ref|XP_003593945.1| | 10 | ||
| – | PREDICTED: la-related protein 7-like [Cicer arietinum] gi|502078710|ref|XP_004486031.1| | 19 | ||
| – | La protein like; TAIR: AT4G32720.2 La protein 1; Swiss-Prot: sp|Q93ZV7|LA1_ARATH La protein 1; TrEMBL-Plants: tr|I1K995|I1K995_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0400000 | 25 | ||
| – | La; TAIR: AT2G43970.1 RNA-binding protein; Swiss-Prot: sp|O80567|LRP6B_ARATH La-related protein 6B; TrEMBL-Plants: tr|I1NCU5|I1NCU5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0800900 | 22 | ||
| – | La; TAIR: AT3G19090.1 RNA-binding protein; Swiss-Prot: sp|Q9LHL3|LRP6C_ARATH La-related protein 6C; TrEMBL-Plants: tr|G7JMI2|G7JMI2_MEDTR LA-related protein 6 LA RNA-binding domain protein; Found in the gene: LotjaGi4g1v0071000 | 25 | ||
| – | La; TAIR: AT5G46250.1 RNA-binding protein; Swiss-Prot: sp|Q94A38|LRP6A_ARATH La-related protein 6A; TrEMBL-Plants: tr|A0A151R8A3|A0A151R8A3_CAJCA La-related protein 7; Found in the gene: LotjaGi6g1v0308500 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 10.00 |