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IPR002715 is a Nascent polypeptide-associated complex NAC domain.
<p>In eukaryotes, the Nascent polypeptide-Associated Complex (NAC) is a heterodimeric cytosolic protein complex composed of NAC alpha (NACA) and NAC beta (BTF3) [[cite:PUB00061597]]. NAC binds reversibly to the ribosome where it is in contact with nascent chains as they emerge from the ribosome. But the cellular function of NAC seems to be much more diverse as it is also involved in transcription regulation and mitochondrial translocation [[cite:PUB00033736], [cite:PUB00097470]]. Alpha and beta NACs share homology with each other, both contain a NAC A/B domain. In archaea no beta NAC proteins are found; the complex is an homodimer of NAC alpha [[cite:PUB00005860], [cite:PUB00031550]].</p> <p>The crystal structure of an archeal NAC has been solved [[cite:PUB00031550]]. The NAC A/B domain consists of six strands arranged in a β-barrel structure similar to the OB fold. Various OB folds interact with ribosomal RNA which could suggest a similar role for the NAC A/B domain.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: transcription factor BTF3-like [Cicer arietinum] gi|502127766|ref|XP_004499826.1| | 7 | ||
| – | Nascent polypeptide-associated complex subunit alpha [Medicago truncatula] gi|357464241|ref|XP_003602402.1| | 9 | ||
| – | PREDICTED: nascent polypeptide-associated complex subunit alpha-like protein 2-like [Glycine max] gi|356516170|ref|XP_003526769.1| | 8 | ||
| – | PREDICTED: nascent polypeptide-associated complex subunit alpha-like protein-like [Glycine max] gi|356571874|ref|XP_003554096.1| | 10 | ||
| – | PREDICTED: nascent polypeptide-associated complex subunit alpha-like protein 1-like [Cicer arietinum] gi|502107593|ref|XP_004493313.1| | 10 | ||
| – | CM0216.550.nc [Lotus japonicus] gi|164605523|dbj|BAF98589.1| | 7 | ||
| – | Nascent polypeptide associated complex alpha subunit, putative; TAIR: AT3G49470.1 nascent polypeptide-associated complex subunit alpha-like protein 2; Swiss-Prot: sp|Q94JX9|NACA2_ARATH Nascent polypeptide-associated complex subunit alpha-like protein 2; TrEMBL-Plants: tr|I3S057|I3S057_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0042200 | 12 | ||
| – | Nascent polypeptide associated complex alpha subunit, putative; TAIR: AT3G49470.1 nascent polypeptide-associated complex subunit alpha-like protein 2; Swiss-Prot: sp|Q94JX9|NACA2_ARATH Nascent polypeptide-associated complex subunit alpha-like protein 2; TrEMBL-Plants: tr|I3SFN2|I3SFN2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0300500 | 12 | ||
| – | Nascent polypeptide-associated complex subunit alpha-like protein; TAIR: AT3G12390.1 Nascent polypeptide-associated complex (NAC), alpha subunit family protein; Swiss-Prot: sp|Q9M612|NACA_PINTA Nascent polypeptide-associated complex subunit alpha-like protein; TrEMBL-Plants: tr|I3T8X0|I3T8X0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0656900 | 12 | ||
| – | Nascent polypeptide-associated complex subunit alpha-like protein; TAIR: AT3G12390.1 Nascent polypeptide-associated complex (NAC), alpha subunit family protein; Swiss-Prot: sp|Q9M612|NACA_PINTA Nascent polypeptide-associated complex subunit alpha-like protein; TrEMBL-Plants: tr|I3T8X0|I3T8X0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0656900 | 12 | ||
| – | Nascent polypeptide-associated complex subunit alpha-like protein; TAIR: AT3G12390.1 Nascent polypeptide-associated complex (NAC), alpha subunit family protein; Swiss-Prot: sp|Q9M612|NACA_PINTA Nascent polypeptide-associated complex subunit alpha-like protein; TrEMBL-Plants: tr|I3T8X0|I3T8X0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0656900 | 13 | ||
| – | Nascent polypeptide-associated complex subunit alpha-like protein; TAIR: AT3G12390.1 Nascent polypeptide-associated complex (NAC), alpha subunit family protein; Swiss-Prot: sp|Q9M612|NACA_PINTA Nascent polypeptide-associated complex subunit alpha-like protein; TrEMBL-Plants: tr|I3S1S2|I3S1S2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0656900 | 12 | ||
| – | Nascent polypeptide-associated complex subunit beta; TAIR: AT1G17880.1 basic transcription factor 3; Swiss-Prot: sp|Q9SMW7|BTF3_ARATH Basic transcription factor 3; TrEMBL-Plants: tr|I3S419|I3S419_LOTJA Nascent polypeptide-associated complex subunit beta; Found in the gene: LotjaGi3g1v0113700 | 10 | ||
| – | Nascent polypeptide-associated complex subunit beta; TAIR: AT1G17880.1 basic transcription factor 3; Swiss-Prot: sp|Q9SMW7|BTF3_ARATH Basic transcription factor 3; TrEMBL-Plants: tr|I3S419|I3S419_LOTJA Nascent polypeptide-associated complex subunit beta; Found in the gene: LotjaGi3g1v0113700 | 10 | ||
| – | Nascent polypeptide-associated complex subunit beta; TAIR: AT1G17880.1 basic transcription factor 3; Swiss-Prot: sp|Q9SMW7|BTF3_ARATH Basic transcription factor 3; TrEMBL-Plants: tr|I3SMY5|I3SMY5_LOTJA Nascent polypeptide-associated complex subunit beta; Found in the gene: LotjaGi3g1v0512100 | 10 | ||
| – | Nascent polypeptide-associated complex subunit beta; TAIR: AT1G17880.1 basic transcription factor 3; Swiss-Prot: sp|Q9SMW7|BTF3_ARATH Basic transcription factor 3; TrEMBL-Plants: tr|I3SMY5|I3SMY5_LOTJA Nascent polypeptide-associated complex subunit beta; Found in the gene: LotjaGi3g1v0512100 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 6.25 |