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IPR002719

Description

IPR002719 is a Retinoblastoma-associated protein, B-box.

<p>This entry includes retinoblastoma-associated protein (RB, also known as pRb, RB, p1051), retinoblastoma-like protein 1 (RBL1, also known as p107) and retinoblastoma-like protein 2 (RBL2, also known as RB2 or p130). Members of this entry contain a conserved domain named the 'pocket' that interacts with the LXCXE motif found in viral proteins, such as SV40 large T antigen [[cite:PUB00067962]]. This pocket consists of A- and B-boxes which are found at the C-terminal end of the protein. This entry represents the B-box, that is on C-terminal side of the A-box. The crystal structure of the RB pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other RB-binding viral and cellular proteins, shows that the LxCxE peptide binds a highly conserved groove on the B-box portion of the pocket; the A-box portion (see [interpro:IPR002720]) appears to be required for the stable folding of the B box. Also highly conserved is the extensive A-B interface, suggesting that it may be an additional protein-binding site. The A and B boxes each contain the cyclin-fold structural motif, with the LxCxE-binding site on the B-box cyclin fold being similar to a Cdk2-binding site of cyclin A and to a TBP-binding site of TFIIB [[cite:PUB00005809], [cite:PUB00004458]].</p> <p>In humans, RB is a tumour suppressor linked to several major cancers [[cite:PUB00067957]]. RB forms complexes with E2Fs and represses gene expression by recruiting chromatin remodeling factors, such as histone deacetylases (HDACs) to E2F-responsive promoters [[cite:PUB00067956], [cite:PUB00067953]]. Apart from E2Fs, RB also interacts with other transcription factors that govern cell differentiation [[cite:PUB00067960], [cite:PUB00067959]].</p> <p>RBL1 and RBL2 are the components of the DREAM complex, which represses cell cycle-dependent genes in quiescent cells and plays a role in the cell cycle-dependent activation of G2/M genes [[cite:PUB00067716], [cite:PUB00067717]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Cellular component Nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
Biological process Regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.

Associated Lotus transcripts 13

Transcript Name Description Predicted domains Domain count
PREDICTED: retinoblastoma-related protein 1-like [Glycine max] gi|356556778|ref|XP_003546699.1| 20
PREDICTED: retinoblastoma-related protein 1-like [Glycine max] gi|356556778|ref|XP_003546699.1| 20
Retinoblastoma-related protein; TAIR: AT3G12280.2 retinoblastoma-related 1; Swiss-Prot: sp|Q9SLZ4|RBR1_PEA Retinoblastoma-related protein 1; TrEMBL-Plants: tr|I1MIM1|I1MIM1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0787400 20
Retinoblastoma-related protein; TAIR: AT3G12280.1 retinoblastoma-related 1; Swiss-Prot: sp|A9UL14|RBR_MEDSA Retinoblastoma-related protein; TrEMBL-Plants: tr|I1MIM1|I1MIM1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0787400 20
Retinoblastoma-related protein; TAIR: AT3G12280.2 retinoblastoma-related 1; Swiss-Prot: sp|Q9SLZ4|RBR1_PEA Retinoblastoma-related protein 1; TrEMBL-Plants: tr|I1MIM1|I1MIM1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0787400 20
Retinoblastoma-related protein; TAIR: AT3G12280.2 retinoblastoma-related 1; Swiss-Prot: sp|Q9SLZ4|RBR1_PEA Retinoblastoma-related protein 1; TrEMBL-Plants: tr|I1MIM1|I1MIM1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0787400 20
Retinoblastoma-related protein; TAIR: AT3G12280.2 retinoblastoma-related 1; Swiss-Prot: sp|Q9SLZ4|RBR1_PEA Retinoblastoma-related protein 1; TrEMBL-Plants: tr|A0A0R0GFY6|A0A0R0GFY6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0787400 20
Retinoblastoma-related protein; TAIR: AT3G12280.2 retinoblastoma-related 1; Swiss-Prot: sp|Q9SLZ4|RBR1_PEA Retinoblastoma-related protein 1; TrEMBL-Plants: tr|I1MIM1|I1MIM1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0315700 20
Retinoblastoma-related protein; TAIR: AT3G12280.2 retinoblastoma-related 1; Swiss-Prot: sp|Q9SLZ4|RBR1_PEA Retinoblastoma-related protein 1; TrEMBL-Plants: tr|I1MIM1|I1MIM1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0315700 20
Retinoblastoma-related protein; TAIR: AT3G12280.2 retinoblastoma-related 1; Swiss-Prot: sp|Q9SLZ4|RBR1_PEA Retinoblastoma-related protein 1; TrEMBL-Plants: tr|I1MIM1|I1MIM1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0315700 20
Retinoblastoma-related protein; TAIR: AT3G12280.2 retinoblastoma-related 1; Swiss-Prot: sp|Q9SLZ4|RBR1_PEA Retinoblastoma-related protein 1; TrEMBL-Plants: tr|I1MIM1|I1MIM1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0315700 20
Retinoblastoma-related protein; TAIR: AT3G12280.2 retinoblastoma-related 1; Swiss-Prot: sp|Q9SLZ4|RBR1_PEA Retinoblastoma-related protein 1; TrEMBL-Plants: tr|I1MIM1|I1MIM1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0315700 20
Retinoblastoma-related protein; TAIR: AT3G12280.2 retinoblastoma-related 1; Swiss-Prot: sp|Q9SLZ4|RBR1_PEA Retinoblastoma-related protein 1; TrEMBL-Plants: tr|A0A0R0GFY6|A0A0R0GFY6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0315700 20

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 7.69