Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR003126 is a Zinc finger, UBR-type.
<p>It has been observed that the identity of N-terminal residues of a protein is related to the half life of the protein. This observation yields a rule, called the N-end rule [[cite:PUB00033766]]. Similar but distinct versions of the N-end rule operate in all organisms examined, from mammals to fungi and bacteria. In eukaryotes, the N-end rule pathway is a part of the ubiquitin degradation system. Some proteins that have a very short half life contain a specific motif at their N terminus, the N-degron. It consists of a destabilising N-terminal residue and an internal Lys, which is the site of poly-Ub chain [[cite:PUB00033766], [cite:PUB00033767]].</p> <p>The UBR1 protein was shown to bind specifically to proteins bearing N-terminal residues that are destabilising according to the N-end rule, but not to otherwise identical proteins bearing stabilising N-terminal residues [[cite:PUB00033768]]. UBR1 contains an N-terminal conserved region (the UBR-type zinc finger) which is also found in various proteins implicated in N-degron recognition. The UBR-type zinc finger defines a unique E3 class, most likely N-degron specific [[cite:PUB00033696]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Zinc ion binding | Interacting selectively and non-covalently with zinc (Zn) ions. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PHD finger-related protein [Medicago truncatula] gi|357481401|ref|XP_003610986.1| | 12 | ||
| – | PREDICTED: E3 ubiquitin-protein ligase UBR3-like [Glycine max] gi|356523153|ref|XP_003530206.1| | 14 | ||
| – | Auxin transport protein BIG; TAIR: AT3G02260.2 auxin transport protein (BIG); Swiss-Prot: sp|Q9SRU2|BIG_ARATH Auxin transport protein BIG; TrEMBL-Plants: tr|G7KRX3|G7KRX3_MEDTR Auxin transporter BIG; Found in the gene: LotjaGi1g1v0519700 | 23 | ||
| – | Auxin transport protein BIG; TAIR: AT3G02260.4 auxin transport protein (BIG); Swiss-Prot: sp|Q9SRU2|BIG_ARATH Auxin transport protein BIG; TrEMBL-Plants: tr|G7KRX3|G7KRX3_MEDTR Auxin transporter BIG; Found in the gene: LotjaGi1g1v0519700 | 21 | ||
| – | E3 ubiquitin-protein ligase; TAIR: AT5G02310.1 proteolysis 6; Swiss-Prot: sp|F4KCC2|PRT6_ARATH E3 ubiquitin-protein ligase PRT6; TrEMBL-Plants: tr|I1KJZ0|I1KJZ0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0580400 | 16 | ||
| – | PHD finger family protein; TAIR: AT4G23860.1 PHD finger protein-like protein; Swiss-Prot: sp|Q8N806|UBR7_HUMAN Putative E3 ubiquitin-protein ligase UBR7; TrEMBL-Plants: tr|I1JAE1|I1JAE1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0441800 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 16.67 |