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IPR004383 is a Ribosomal RNA large subunit methyltransferase RlmN/Cfr.
<p>This entry represents the RlmN family, that includes dual-specificity RNA methyltransferase RlmN and ribosomal RNA large subunit methyltransferase Cfr.</p> <p>Dual-specificity RNA methyltransferase RlmN specifically methylates position 2 of adenine 2503 in 23S rRNA [[cite:PUB00046147]]. This nucleotide is located in a functionally important region of the ribosome, at the entrance to the nascent peptide exit tunnel, and may thus be involved in the interaction with the nascent peptide. It also methylates position 2 of adenine 37 in tRNAs. Unmodified tRNA is not a suitable substrate for RlmN, which suggests that RlmN works in a late step during tRNA maturation [[cite:PUB00046147], [cite:PUB00064728], [cite:PUB00064729]].</p> <p>Ribosomal RNA large subunit methyltransferase Cfr specifically methylates position 8 of adenine 2503 in 23S rRNA. It can also methylate position 2 of A2503 after the primary methylation is complete, to form 2,8-dimethyladenosine. Cfr confers antibiotic resistance in bacteria. The antibiotic resistance is provided by methylation at the 8 position and is independent of methylation at the 2 position of A2503 [[cite:PUB00017347], [cite:PUB00064730]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | RRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. | ||
| Molecular function | RNA methyltransferase activity | Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: dual-specificity RNA methyltransferase RlmN-like [Cicer arietinum] gi|502184040|ref|XP_004517271.1| | 10 | ||
| – | PREDICTED: dual-specificity RNA methyltransferase RlmN-like [Cicer arietinum] gi|502184040|ref|XP_004517271.1| | 10 | ||
| – | PREDICTED: probable dual-specificity RNA methyltransferase RlmN-like [Cicer arietinum] gi|502097051|ref|XP_004490899.1| | 22 | ||
| – | Dual-specificity RNA methyltransferase RlmN; TAIR: AT2G39670.1 Radical SAM superfamily protein; Swiss-Prot: sp|Q8DG98|RLMN_THEEB Probable dual-specificity RNA methyltransferase RlmN; TrEMBL-Plants: tr|G7KBR0|G7KBR0_MEDTR 23S rRNA m2A2503 methyltransferase; Found in the gene: LotjaGi1g1v0090900 | 24 | ||
| – | Dual-specificity RNA methyltransferase RlmN; TAIR: AT3G19630.1 Radical SAM superfamily protein; Swiss-Prot: sp|Q6MDD0|RLMN2_PARUW Probable dual-specificity RNA methyltransferase RlmN 2; TrEMBL-Plants: tr|I3T8H2|I3T8H2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0459900 | 15 | ||
| – | Dual-specificity RNA methyltransferase RlmN; TAIR: AT1G60230.1 Radical SAM superfamily protein; Swiss-Prot: sp|A0LQM1|RLMN_SYNFM Dual-specificity RNA methyltransferase RlmN; TrEMBL-Plants: tr|I1KXG4|I1KXG4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0165700 | 23 | ||
| – | Dual-specificity RNA methyltransferase RlmN; TAIR: AT1G60230.1 Radical SAM superfamily protein; Swiss-Prot: sp|Q3A2Z4|RLMN_PELCD Dual-specificity RNA methyltransferase RlmN; TrEMBL-Plants: tr|V7C8D7|V7C8D7_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0165700 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01335 | CDD | 1 | 14.29 |