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IPR005034 is a Dicer dimerisation domain.
<p>This domain is found in members of the Dicer protein family which function in RNA interference, an evolutionarily conserved mechanism for gene silencing using double-stranded RNA (dsRNA) molecules. It is essential for the activity of Dicer [[cite:PUB00067933], [cite:PUB00043694]]. It is a divergent double stranded RNA-binding domain [[cite:PUB00043692]]. The N-terminal α helix of this domain is in a different orientation to that found in canonical dsRNA-binding domains. This results in a change of charge distribution at the potential dsRNA-binding surface and in the N- and C-termini of the domain being in close proximity [[cite:PUB00066744]]. This domain has weak dsRNA-binding activity. It mediates heterodimerisation of Dicer proteins with their respective protein partners [[cite:PUB00066744]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Endoribonuclease activity, producing 5'-phosphomonoesters | Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: dicer-like protein 4-like [Glycine max] gi|356565129|ref|XP_003550797.1| | 40 | ||
| – | PREDICTED: dicer-like protein 4-like [Glycine max] gi|356565129|ref|XP_003550797.1| | 40 | ||
| – | PREDICTED: LOW QUALITY PROTEIN: endoribonuclease Dicer homolog 3a-like [Cicer arietinum] gi|502132552|ref|XP_004501416.1| | 38 | ||
| – | PREDICTED: endoribonuclease Dicer homolog 1-like [Glycine max] gi|356571277|ref|XP_003553805.1| | 25 | ||
| – | PREDICTED: LOW QUALITY PROTEIN: endoribonuclease Dicer homolog 3a-like [Cicer arietinum] gi|502132552|ref|XP_004501416.1| | 29 | ||
| – | PREDICTED: endoribonuclease Dicer homolog 2-like [Cicer arietinum] gi|502080138|ref|XP_004486471.1| | 5 | ||
| – | Dicer-like protein 3; TAIR: AT3G43920.2 dicer-like 3; Swiss-Prot: sp|Q5N870|DCL3A_ORYSJ Endoribonuclease Dicer homolog 3a; TrEMBL-Plants: tr|K7KIB7|K7KIB7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0372300 | 41 | ||
| – | Endoribonuclease Dicer-like protein 3; TAIR: AT1G01040.1 dicer-like 1; Swiss-Prot: sp|Q9SP32|DCL1_ARATH Endoribonuclease Dicer homolog 1; TrEMBL-Plants: tr|K7N0F5|K7N0F5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0798000 | 44 | ||
| – | Endoribonuclease Dicer-like protein 3; TAIR: AT1G01040.1 dicer-like 1; Swiss-Prot: sp|Q9SP32|DCL1_ARATH Endoribonuclease Dicer homolog 1; TrEMBL-Plants: tr|K7N0F5|K7N0F5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0798000 | 44 | ||
| – | Endoribonuclease Dicer-like protein 3; TAIR: AT1G01040.1 dicer-like 1; Swiss-Prot: sp|Q9SP32|DCL1_ARATH Endoribonuclease Dicer homolog 1; TrEMBL-Plants: tr|K7N0F5|K7N0F5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0798000 | 44 | ||
| – | ATP-dependent RNA helicase FAL1; TAIR: AT3G03300.1 dicer-like 2; Swiss-Prot: sp|Q3EBC8|DCL2_ARATH Endoribonuclease Dicer homolog 2; TrEMBL-Plants: tr|I1L0G0|I1L0G0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0077900_LC | 16 | ||
| – | ATP-dependent RNA helicase RhlB; TAIR: AT3G03300.1 dicer-like 2; Swiss-Prot: sp|Q3EBC8|DCL2_ARATH Endoribonuclease Dicer homolog 2; TrEMBL-Plants: tr|I1L0G0|I1L0G0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0077900_LC | 21 | ||
| – | Dicer-like 3; TAIR: AT5G20320.1 dicer-like 4; Swiss-Prot: sp|P84634|DCL4_ARATH Dicer-like protein 4; TrEMBL-Plants: tr|K7MKZ2|K7MKZ2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0283700 | 45 | ||
| – | Endoribonuclease Dicer-like protein 3; TAIR: AT3G03300.1 dicer-like 2; Swiss-Prot: sp|Q3EBC8|DCL2_ARATH Endoribonuclease Dicer homolog 2; TrEMBL-Plants: tr|I1L0G0|I1L0G0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0269600 | 37 | ||
| – | Endoribonuclease Dicer-like protein 3; TAIR: AT3G03300.1 dicer-like 2; Swiss-Prot: sp|Q3EBC8|DCL2_ARATH Endoribonuclease Dicer homolog 2; TrEMBL-Plants: tr|I1L0G0|I1L0G0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0269600 | 37 | ||
| – | Endoribonuclease dicer-like protein; TAIR: AT3G03300.1 dicer-like 2; Swiss-Prot: sp|Q3EBC8|DCL2_ARATH Endoribonuclease Dicer homolog 2; TrEMBL-Plants: tr|A0A1J7G653|A0A1J7G653_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0269700_LC | 7 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR14950:SF37 | PANTHER | 1 | 6.25 |