Description

IPR005786 is a Branched-chain amino acid aminotransferase II.

<p>Aminotransferases share certain mechanistic features with other pyridoxal-phosphate dependent enzymes, such as the covalent binding of the pyridoxal-phosphate group to a lysine residue. On the basis of sequence similarity, these various enzymes can be grouped [[cite:PUB00002195]] into subfamilies.</p> <p>One of these, called class-IV, currently consists of proteins of about 270 to 415 amino-acid residues that share a few regions of sequence similarity. Surprisingly, the best conserved region does not include the lysine residue to which the pyridoxal-phosphate group is known to be attached, in ilvE, but is located some 40 residues at the C terminus side of the PlP-lysine.</p> <p>Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE) ([ec:2.6.1.42]). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family less similar to the DAAT family.</p> <p>Also included in this group is branched-chain amino acid aminotransferase gloG from the yeast<i>Glarea lozoyensis</i>, which is required for biosynthesis of the mycotoxin pneumocandin, a lipohexapeptide of the echinocandin family [[cite:PUB00089640]]. Transaminase AMT5 from the Alternaria rot fungus is one of many enzymes required for the non-ribosomal biosynthesis of the cyclic depsipeptides known as AM-toxins [[cite:PUB00089814]]. The aminotransferase FGSG_00049 from Fusarium graminearum is part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat, suggesting host-specific adaptation [[cite:PUB00094557]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 19

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: