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IPR010614 is a RAD3-like helicase, DEAD.
<p>This domain is found in the RAD3-like DNA-binding helicase Regulator of telomere elongation helicase 1 homolog from Drosophila melanogaster (Rtel1), General transcription and DNA repair factor IIH helicase subunit XPD from Saccharomyces cerevisiae (RAD3) and similar proteins that are seemingly ubiquitous, including members of eukaryotic, bacterial and archaeal origin.</p> <p>Regulator of telomere elongation helicase 1 (Rtel1) is the animal functional analogue of yeast Srs2, which is a DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery [[cite:PUB00074223]]. Rtel1 is an essential DNA helicase that disassembles a variety of DNA secondary structures to facilitate DNA replication, repair, and recombination processes, and to maintain both telomeric and genomic stability [[cite:PUB00153326], [cite:PUB00074226], [cite:PUB00074118], [cite:PUB00103976]]. It is recruited by Trf2 to telomeres in S phase to promote T-Loop unwinding [[cite:PUB00074228]]. It is also required for the export and the correct cytoplasmic trafficking of the small nuclear (sn) RNA pre-U2, a component of the major spliceosome complex [[cite:PUB00074225]]. Human Rtel1 is implicated in the etiology of Dyskeratosis congenital (DC, is an inherited bone marrow failure and cancer predisposition syndrome) [[cite:PUB00133413]]. Point mutations in its helicase domains, and truncations which result in loss of its C terminus have been discovered in DC families. It acts as anti-recombinase and antagonises homologous recombination by promoting the disassembly of D loop recombination intermediates in a reaction dependent upon ATP hydrolysis [[cite:PUB00074223]]. Rtel1 is also a candidate gene influencing glioma susceptibility [[cite:PUB00074223], [cite:PUB00133415], [cite:PUB00133416]].</p> <p>RAD3 is involved in nucleotide excision repair, and forms part of the transcription factor TFIIH in yeast [[cite:PUB00007684]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Molecular function | DNA helicase activity | Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix. | ||
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | ATP-dependent RNA helicase chl1 [Medicago truncatula] gi|357468391|ref|XP_003604480.1| | 10 | ||
| – | PREDICTED: probable ATP-dependent RNA helicase DDX11-like isoform X2 [Cicer arietinum] gi|502147607|ref|XP_004506847.1| | 18 | ||
| – | PREDICTED: regulator of telomere elongation helicase 1-like [Glycine max] gi|356547406|ref|XP_003542103.1| | 13 | ||
| – | PREDICTED: Fanconi anemia group J protein homolog isoform X1 [Cicer arietinum] gi|502162740|ref|XP_004512601.1| | 12 | ||
| – | DNA repair helicase; TAIR: AT1G03190.1 RAD3-like DNA-binding helicase protein; Swiss-Prot: sp|Q8W4M7|ERCC2_ARATH DNA repair helicase XPD; TrEMBL-Plants: tr|A0A0L9VKH8|A0A0L9VKH8_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0132200 | 24 | ||
| – | DNA repair helicase; TAIR: AT1G03190.1 RAD3-like DNA-binding helicase protein; Swiss-Prot: sp|Q8W4M7|ERCC2_ARATH DNA repair helicase XPD; TrEMBL-Plants: tr|A0A0L9VKH8|A0A0L9VKH8_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0132200 | 23 | ||
| – | Helicase-related family protein; TAIR: AT1G79950.1 RAD3-like DNA-binding helicase protein; Swiss-Prot: sp|A4K436|RTEL1_BOVIN Regulator of telomere elongation helicase 1; TrEMBL-Plants: tr|K7M3U8|K7M3U8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0016400 | 21 | ||
| – | Rad3-related DNA helicase family protein; TAIR: AT1G79890.1 RAD3-like DNA-binding helicase protein; Swiss-Prot: sp|F1R345|DDX11_DANRE ATP-dependent DNA helicase DDX11; TrEMBL-Plants: tr|I1KG67|I1KG67_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0366000 | 24 | ||
| – | Rad3-related DNA helicase family protein; TAIR: AT1G79890.1 RAD3-like DNA-binding helicase protein; Swiss-Prot: sp|F1R345|DDX11_DANRE ATP-dependent DNA helicase DDX11; TrEMBL-Plants: tr|A0A072TSN1|A0A072TSN1_MEDTR Rad3-related DNA helicase family protein; Found in the gene: LotjaGi3g1v0366000 | 16 | ||
| – | Helicase-related family protein; TAIR: AT1G20720.2 RAD3-like DNA-binding helicase protein; Swiss-Prot: sp|Q5SXJ3|FANCJ_MOUSE Fanconi anemia group J protein homolog; TrEMBL-Plants: tr|K7M8G7|K7M8G7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0000800 | 20 | ||
| – | Helicase-related family protein; TAIR: AT1G20720.2 RAD3-like DNA-binding helicase protein; Swiss-Prot: sp|Q3YK19|FANCJ_CHICK Fanconi anemia group J protein homolog; TrEMBL-Plants: tr|K7M8G7|K7M8G7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0000800 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 9.09 |