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IPR012763 is a DNA polymerase III, subunit gamma/ tau, N-terminal.
<p>This entry represents the well-conserved first N-terminal domain of DnaX (also known as DNA polymerase III subunit gamma/tau), approx. 365 aa. The full-length product of the dnaX gene in Escherichia coli encodes the DNA polymerase III tau subunit. A translational frameshift leads to early termination and a truncated protein subunit gamma, about 1/3 shorter than tau and present in roughly equal amounts. This frameshift mechanism is not necessarily universal for species with DNA polymerase III but appears conserved in the extreme thermophile Thermus thermophilus.</p> <p>This domain is also found in protein STICHEL and STICHEL-like (STI) from Arabidopsis, which share sequence similarity with DNA polymerase III gamma/tau subunits [[cite:PUB00101309], [cite:PUB00101310]]. STI is nuclear-localized and does not participate in genome duplication; it is a key regulator of trichome branching through an endoreduplication-independent pathway [[cite:PUB00095753]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA-directed DNA polymerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. | ||
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Biological process | DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. | ||
| Cellular component | DNA polymerase III complex | The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | DNA polymerase III subunit gamma/tau [Medicago truncatula] gi|358348981|ref|XP_003638519.1| | 15 | ||
| – | Trichome branching-like protein [Gossypium arboreum] gi|395399800|gb|AFN58239.1| | 19 | ||
| – | Trichome branching-like protein [Gossypium arboreum] gi|395399800|gb|AFN58239.1| | 13 | ||
| – | DNA polymerase III subunit gamma/tau [Medicago truncatula] gi|357477253|ref|XP_003608912.1| | 14 | ||
| – | DNA polymerase III subunit; TAIR: AT4G24790.1 AAA-type ATPase family protein; Swiss-Prot: sp|F4JRP8|STIL2_ARATH Protein STICHEL-like 2; TrEMBL-Plants: tr|A0A151RVR2|A0A151RVR2_CAJCA DNA polymerase III subunit gamma/tau; Found in the gene: LotjaGi1g1v0230800 | 15 | ||
| – | DNA polymerase III subunit; TAIR: AT2G02480.1 AAA-type ATPase family protein; Swiss-Prot: sp|O64728|STI_ARATH Protein STICHEL; TrEMBL-Plants: tr|I1KNQ8|I1KNQ8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0002600 | 19 | ||
| – | Holliday junction ATP-dependent DNA helicase RuvB; TAIR: AT4G24790.1 AAA-type ATPase family protein; Swiss-Prot: sp|F4JRP8|STIL2_ARATH Protein STICHEL-like 2; TrEMBL-Plants: tr|A0A0B2RQ22|A0A0B2RQ22_GLYSO DNA polymerase III subunit gamma/tau; Found in the gene: LotjaGi4g1v0225500 | 14 | ||
| – | Holliday junction ATP-dependent DNA helicase RuvB; TAIR: AT4G24790.1 AAA-type ATPase family protein; Swiss-Prot: sp|F4JRP8|STIL2_ARATH Protein STICHEL-like 2; TrEMBL-Plants: tr|A0A0B2RQ22|A0A0B2RQ22_GLYSO DNA polymerase III subunit gamma/tau; Found in the gene: LotjaGi4g1v0225500 | 14 | ||
| – | DNA polymerase III subunit gamma; TAIR: AT4G18820.1 AAA-type ATPase family protein; Swiss-Prot: sp|F4JRP0|STIL3_ARATH Protein STICHEL-like 3; TrEMBL-Plants: tr|I1M1Q6|I1M1Q6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0319100 | 17 | ||
| – | DNA polymerase III subunit gamma; TAIR: AT4G18820.1 AAA-type ATPase family protein; Swiss-Prot: sp|F4JRP0|STIL3_ARATH Protein STICHEL-like 3; TrEMBL-Plants: tr|I1M1Q6|I1M1Q6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0319100 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 10.00 |