Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR013150 is a Transcription factor TFIIB, cyclin-like domain.
<p>In eukaryotes, transcription initiation of all protein encoding genes involves the polymerase II system. This sytem is modulated by both general and specific transcription factors. The general factors (which include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIG and TFIIH) operate through common promoter elements, such as the TATA box. Transcription factor IIB (TFIIB) is of central importance in transcription of class II genes. It associates with TFIID-TFIIA bound to DNA (the DA complex) to form a ternary TFIID-IIA-IBB (DAB) complex, which is recognised by RNA polymerase II [[cite:PUB00004101], [cite:PUB00005378]]. TFIIB comprises ~315-340 residues and contains an imperfect C-terminal repeat of a 75-residue domain that may contribute to the symmetry of the folded protein. The basal archaeal transcription machinery resembles that of the eukaryotic polymerase II system and includes a homologue of TFIIB [[cite:PUB00004866]].</p> <p>This entry represents a cyclin-like domain which is found repeated in the C-terminal region of a variety of eukaryotic TFIIB's and their archaeal counterparts. These domains individually form the typical cyclin fold, and in the transcription complex they straddle the C-terminal region of the TATA-binding protein - an interaction essential for the formation of the transcription initiation complex [[cite:PUB00023347], [cite:PUB00021313]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Molecular function | TBP-class protein binding | Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs). |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | PREDICTED: transcription initiation factor IIB-like [Fragaria vesca subsp]. vesca] gi|470137151|ref|XP_004304334.1| | 13 | ||
– | PREDICTED: transcription factor IIIB 90 kDa subunit-like [Cicer arietinum] gi|502091837|ref|XP_004489648.1| | 17 | ||
– | PREDICTED: transcription initiation factor IIB-like [Fragaria vesca subsp]. vesca] gi|470137151|ref|XP_004304334.1| | 13 | ||
– | PREDICTED: transcription initiation factor IIB 7-like isoform X2 [Cicer arietinum] gi|502161095|ref|XP_004512023.1| | 12 | ||
– | PREDICTED: transcription initiation factor IIB 7-like isoform X2 [Cicer arietinum] gi|502161095|ref|XP_004512023.1| | 11 | ||
– | PREDICTED: transcription initiation factor IIB-like [Fragaria vesca subsp]. vesca] gi|470137151|ref|XP_004304334.1| | 18 | ||
– | PREDICTED: transcription factor IIIB 90 kDa subunit-like [Cicer arietinum] gi|502091837|ref|XP_004489648.1| | 17 | ||
– | Transcription initiation factor IIB; TAIR: AT3G10330.1 Cyclin-like family protein; Swiss-Prot: sp|P48513|TF2B_SOYBN Transcription initiation factor IIB; TrEMBL-Plants: tr|A0A151U2X6|A0A151U2X6_CAJCA Transcription initiation factor IIB; Found in the gene: LotjaGi1g1v0671300 | 19 | ||
– | Transcription initiation factor IIB; TAIR: AT3G10330.1 Cyclin-like family protein; Swiss-Prot: sp|P48513|TF2B_SOYBN Transcription initiation factor IIB; TrEMBL-Plants: tr|A0A151U2X6|A0A151U2X6_CAJCA Transcription initiation factor IIB; Found in the gene: LotjaGi1g1v0671300 | 14 | ||
– | Transcription factor, putative; TAIR: AT3G09360.1 Cyclin/Brf1-like TBP-binding protein; Swiss-Prot: sp|Q8CFK2|TF3B_MOUSE Transcription factor IIIB 90 kDa subunit; TrEMBL-Plants: tr|A0A1J7FQ67|A0A1J7FQ67_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0094100 | 19 | ||
– | Transcription initiation factor IIB; TAIR: AT4G36650.1 plant-specific TFIIB-related protein; Swiss-Prot: sp|O23215|PBRP1_ARATH Plant-specific TFIIB-related protein 1; TrEMBL-Plants: tr|I1J8V2|I1J8V2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0391100 | 13 | ||
– | Transcription initiation factor IIB; TAIR: AT3G10330.1 Cyclin-like family protein; Swiss-Prot: sp|Q9SS44|TF2B2_ARATH Transcription initiation factor IIB-2; TrEMBL-Plants: tr|A0A151U2X6|A0A151U2X6_CAJCA Transcription initiation factor IIB; Found in the gene: LotjaGi5g1v0136500 | 19 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
cd00043 | CDD | 1 | 8.33 |