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IPR000812 is a Transcription factor TFIIB.
<p>In eukaryotes, transcription initiation by polymerase II is modulated by both general and specific transcription factors. The general factors (which include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIG and TFIIH) operate through common promoter elements, such as the TATA box. Transcription factor IIB (TFIIB) is of central importance in transcription of class II genes. It associates with TFIID-TFIIA bound to DNA (the DA complex) to form a ternary TFIID-IIA-IBB (DAB) complex, which is recognised by RNA polymerase II [[cite:PUB00004101], [cite:PUB00005378]]. TFIIB comprises ~315-340 residues and contains an imperfect C-terminal repeat of a 75-residue domain that may contribute to the symmetry of the folded protein.</p> <p>Proteins in this entry also include transcription factor IIIB subunit Brf1, which shares protein sequence similarity with TFIIB. In budding yeast, Brf1 interacts with several initiation-specific subunits of the pol III machinery, TBP, beta", TFC4p and the pol III subunits C34 and C17 [[cite:PUB00056255]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Regulation of transcription, DNA-templated | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. | ||
| Biological process | Transcription preinitiation complex assembly | The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), required for transcription. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: transcription initiation factor IIB-like [Fragaria vesca subsp]. vesca] gi|470137151|ref|XP_004304334.1| | 13 | ||
| – | PREDICTED: transcription factor IIIB 90 kDa subunit-like [Cicer arietinum] gi|502091837|ref|XP_004489648.1| | 17 | ||
| – | PREDICTED: transcription initiation factor IIB-like [Fragaria vesca subsp]. vesca] gi|470137151|ref|XP_004304334.1| | 13 | ||
| – | PREDICTED: transcription initiation factor IIB 7-like isoform X2 [Cicer arietinum] gi|502161095|ref|XP_004512023.1| | 12 | ||
| – | PREDICTED: transcription initiation factor IIB 7-like isoform X2 [Cicer arietinum] gi|502161095|ref|XP_004512023.1| | 11 | ||
| – | PREDICTED: transcription initiation factor IIB-like [Fragaria vesca subsp]. vesca] gi|470137151|ref|XP_004304334.1| | 18 | ||
| – | PREDICTED: transcription factor IIIB 90 kDa subunit-like [Cicer arietinum] gi|502091837|ref|XP_004489648.1| | 17 | ||
| – | PREDICTED: transcription factor IIIB 90 kDa subunit-like [Cicer arietinum] gi|502091837|ref|XP_004489648.1| | 15 | ||
| – | PREDICTED: transcription factor IIIB 90 kDa subunit-like [Cicer arietinum] gi|502091837|ref|XP_004489648.1| | 15 | ||
| – | PREDICTED: transcription factor IIIB 50 kDa subunit-like [Glycine max] gi|356497852|ref|XP_003517770.1| | 7 | ||
| – | Transcription initiation factor IIB; TAIR: AT3G10330.1 Cyclin-like family protein; Swiss-Prot: sp|P48513|TF2B_SOYBN Transcription initiation factor IIB; TrEMBL-Plants: tr|A0A151U2X6|A0A151U2X6_CAJCA Transcription initiation factor IIB; Found in the gene: LotjaGi1g1v0671300 | 19 | ||
| – | Transcription initiation factor IIB; TAIR: AT3G10330.1 Cyclin-like family protein; Swiss-Prot: sp|Q9SS44|TF2B2_ARATH Transcription initiation factor IIB-2; TrEMBL-Plants: tr|A0A059DI46|A0A059DI46_EUCGR Uncharacterized protein; Found in the gene: LotjaGi1g1v0671300 | 10 | ||
| – | Transcription initiation factor IIB; TAIR: AT3G10330.1 Cyclin-like family protein; Swiss-Prot: sp|P48513|TF2B_SOYBN Transcription initiation factor IIB; TrEMBL-Plants: tr|A0A151U2X6|A0A151U2X6_CAJCA Transcription initiation factor IIB; Found in the gene: LotjaGi1g1v0671300 | 14 | ||
| – | Transcription factor IIIB 90 kDa subunit; TAIR: AT3G09360.1 Cyclin/Brf1-like TBP-binding protein; Swiss-Prot: sp|Q8HYB2|GGTA1_LEMCA N-acetyllactosaminide alpha-1,3-galactosyltransferase; TrEMBL-Plants: tr|I3S7K7|I3S7K7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0094000_LC | 4 | ||
| – | Transcription factor IIIB 90 kDa subunit; TAIR: AT3G09360.1 Cyclin/Brf1-like TBP-binding protein; Swiss-Prot: sp|Q8HYB2|GGTA1_LEMCA N-acetyllactosaminide alpha-1,3-galactosyltransferase; TrEMBL-Plants: tr|I3S7K7|I3S7K7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0094000_LC | 5 | ||
| – | Transcription factor, putative; TAIR: AT3G09360.1 Cyclin/Brf1-like TBP-binding protein; Swiss-Prot: sp|Q8CFK2|TF3B_MOUSE Transcription factor IIIB 90 kDa subunit; TrEMBL-Plants: tr|A0A1J7FQ67|A0A1J7FQ67_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0094100 | 19 | ||
| – | Transcription initiation factor IIB; TAIR: AT4G36650.1 plant-specific TFIIB-related protein; Swiss-Prot: sp|O23215|PBRP1_ARATH Plant-specific TFIIB-related protein 1; TrEMBL-Plants: tr|I1J8V2|I1J8V2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0391100 | 13 | ||
| – | Transcription initiation factor IIB; TAIR: AT3G10330.1 Cyclin-like family protein; Swiss-Prot: sp|Q9SS44|TF2B2_ARATH Transcription initiation factor IIB-2; TrEMBL-Plants: tr|A0A151U2X6|A0A151U2X6_CAJCA Transcription initiation factor IIB; Found in the gene: LotjaGi5g1v0136500 | 19 | ||
| – | Transcription initiation factor IIB; TAIR: AT3G10330.1 Cyclin-like family protein; Swiss-Prot: sp|Q9SS44|TF2B2_ARATH Transcription initiation factor IIB-2; TrEMBL-Plants: tr|A0A151U2X6|A0A151U2X6_CAJCA Transcription initiation factor IIB; Found in the gene: LotjaGi5g1v0136500 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 5.26 |