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IPR015807 is a Histidine-tRNA ligase.
<p>Histidine-tRNA ligase (also known as histidyl-tRNA synthetase) ([ec:6.1.1.21]) is an alpha2 dimer that belongs to class IIa. Every completed genome includes a histidine-tRNA ligase. Apparent second copies from Bacillus subtilis, Synechocystis sp. (strain PCC 6803), and Aquifex aeolicus are slightly shorter, more closely related to each other than to other hisS proteins, and not demonstrated to act as histidine-tRNA ligases (see [interpro:IPR004517]). The regulatory protein kinase GCN2 of Saccharomyces cerevisiae (YDR283c), and related proteins from other species designated eIF-2 alpha kinase, have a domain closely related to histidine-tRNA ligase that may serve to detect and respond to uncharged tRNA(his), an indicator of amino acid starvation, but these regulatory proteins are not orthologous.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Histidine-tRNA ligase activity | Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). | ||
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Biological process | Histidyl-tRNA aminoacylation | The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: histidyl-tRNA synthetase-like [Glycine max] gi|356505252|ref|XP_003521406.1| | 20 | ||
| – | PREDICTED: histidine--tRNA ligase-like [Cicer arietinum] gi|502122299|ref|XP_004497677.1| | 23 | ||
| – | Histidine--tRNA ligase; TAIR: AT3G46100.1 Histidyl-tRNA synthetase 1; Swiss-Prot: sp|O82413|SYHM_ARATH Histidine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|I1JPP8|I1JPP8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0688700 | 23 | ||
| – | Histidine--tRNA ligase; TAIR: AT3G46100.1 Histidyl-tRNA synthetase 1; Swiss-Prot: sp|O82413|SYHM_ARATH Histidine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|I1JPP8|I1JPP8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0688700 | 23 | ||
| – | Histidine--tRNA ligase; TAIR: AT3G02760.1 Class II aaRS and biotin synthetases superfamily protein; Swiss-Prot: sp|F4IYF8|SYHC_ARATH Histidine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|A0A072VJI1|A0A072VJI1_MEDTR Histidyl-tRNA synthetase; Found in the gene: LotjaGi4g1v0456100 | 24 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00859 | CDD | 1 | 20.00 |