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IPR041715 is a Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain.
<p>HisRS is a homodimer and is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs [[cite:PUB00091719]]. This domain is also found at the C terminus of eukaryotic GCN2 protein kinase [[cite:PUB00091720]] and at the N terminus of the ATP phosphoribosyltransferase accessory subunit, HisZ. HisZ along with HisG catalyze the first reaction in histidine biosynthesis. HisZ is found only in a subset of bacteria and differs from HisRS in lacking a C-terminal anti-codon binding domain [[cite:PUB00028139]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Histidine--tRNA ligase; TAIR: AT3G46100.1 Histidyl-tRNA synthetase 1; Swiss-Prot: sp|O82413|SYHM_ARATH Histidine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|I1JPP8|I1JPP8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0688700 | 23 | ||
| – | Histidine--tRNA ligase; TAIR: AT3G46100.1 Histidyl-tRNA synthetase 1; Swiss-Prot: sp|O82413|SYHM_ARATH Histidine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|K7KFU0|K7KFU0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0688700 | 20 | ||
| – | Histidine--tRNA ligase; TAIR: AT3G46100.1 Histidyl-tRNA synthetase 1; Swiss-Prot: sp|O82413|SYHM_ARATH Histidine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|I1JPP8|I1JPP8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0688700 | 20 | ||
| – | Histidine--tRNA ligase; TAIR: AT3G46100.1 Histidyl-tRNA synthetase 1; Swiss-Prot: sp|O82413|SYHM_ARATH Histidine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|I1JPP8|I1JPP8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0688700 | 23 | ||
| – | Histidine--tRNA ligase; TAIR: AT3G46100.1 Histidyl-tRNA synthetase 1; Swiss-Prot: sp|O82413|SYHM_ARATH Histidine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|K7KFU0|K7KFU0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0688700 | 14 | ||
| – | Protein kinase family protein; TAIR: AT3G59410.4 protein kinase family protein; Swiss-Prot: sp|Q9LX30|GCN2_ARATH eIF-2-alpha kinase GCN2; TrEMBL-Plants: tr|A0A151RUS1|A0A151RUS1_CAJCA Putative serine/threonine-protein kinase GCN2; Found in the gene: LotjaGi3g1v0498400 | 32 | ||
| – | Histidine--tRNA ligase; TAIR: AT3G02760.1 Class II aaRS and biotin synthetases superfamily protein; Swiss-Prot: sp|F4IYF8|SYHC_ARATH Histidine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|A0A072VJI1|A0A072VJI1_MEDTR Histidyl-tRNA synthetase; Found in the gene: LotjaGi4g1v0456100 | 24 | ||
| – | Histidine--tRNA ligase; TAIR: AT3G02760.1 Class II aaRS and biotin synthetases superfamily protein; Swiss-Prot: sp|F4IYF8|SYHC_ARATH Histidine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|A0A072VJI1|A0A072VJI1_MEDTR Histidyl-tRNA synthetase; Found in the gene: LotjaGi4g1v0456100 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00773 | CDD | 1 | 12.50 |