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IPR016142 is a Citrate synthase-like, large alpha subdomain.
<p>This entry represents the large α-helical domain from type I and II citrate synthase enzymes, as well as a homologous domain found in the related enzyme 2-methylcitrate synthase. 2-Methylcitrate ([ec:2.3.3.5]) synthase catalyses the conversion of oxaloacetate and propanoyl-CoA into (2R,3S)-2-hydroxybutane-1,2,3-tricarboxylate and coenzyme A. This enzyme is induced during bacterial growth on propionate, while type II hexameric citrate synthase is constitutive [[cite:PUB00013490]].</p> <p>Citrate synthase [ec:2.3.3.1] is a member of a small family of enzymes that can directly form a carbon-carbon bond without the presence of metal ion cofactors. It catalyses the first reaction in the Krebs' cycle, namely the conversion of oxaloacetate and acetyl-coenzyme A into citrate and coenzyme A. This reaction is important for energy generation and for carbon assimilation. The reaction proceeds via a non-covalently bound citryl-coenzyme A intermediate in a 2-step process (aldol-Claisen condensation followed by the hydrolysis of citryl-CoA).</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Citrate synthase [Medicago truncatula] gi|357494363|ref|XP_003617470.1| | 18 | ||
| – | PREDICTED: citrate synthase, mitochondrial-like [Glycine max] gi|356525687|ref|XP_003531455.1| | 13 | ||
| – | PREDICTED: ATP-citrate synthase beta chain protein 1-like [Glycine max] gi|356556001|ref|XP_003546316.1| | 23 | ||
| – | ATP citrate lyase alpha subunit [Glycyrrhiza uralensis] gi|148872938|gb|ABR15094.1| | 25 | ||
| – | Citrate synthase [Medicago truncatula] gi|357459271|ref|XP_003599916.1| | 13 | ||
| – | PREDICTED: ATP-citrate synthase beta chain protein 1-like [Glycine max] gi|356556001|ref|XP_003546316.1| | 23 | ||
| – | Citrate synthase; TAIR: AT2G42790.1 citrate synthase 3; Swiss-Prot: sp|P49299|CYSZ_CUCMA Citrate synthase, glyoxysomal; TrEMBL-Plants: tr|G7K3F1|G7K3F1_MEDTR Citrate synthase; Found in the gene: LotjaGi1g1v0038100 | 19 | ||
| – | Citrate synthase; TAIR: AT2G44350.1 Citrate synthase family protein; Swiss-Prot: sp|P49298|CISY_CITMA Citrate synthase, mitochondrial; TrEMBL-Plants: tr|A0A0L9UJS8|A0A0L9UJS8_PHAAN Citrate synthase; Found in the gene: LotjaGi3g1v0127400 | 16 | ||
| – | Citrate synthase; TAIR: AT2G44350.1 Citrate synthase family protein; Swiss-Prot: sp|P49298|CISY_CITMA Citrate synthase, mitochondrial; TrEMBL-Plants: tr|A0A072V8L1|A0A072V8L1_MEDTR Citrate synthase; Found in the gene: LotjaGi3g1v0127400 | 20 | ||
| – | ATP-citrate synthase, putative; TAIR: AT3G06650.1 ATP-citrate lyase B-1; Swiss-Prot: sp|Q93VT8|ACLB1_ORYSJ ATP-citrate synthase beta chain protein 1; TrEMBL-Plants: tr|A6MZ92|A6MZ92_GLYUR ATP citrate lyase alpha subunit; Found in the gene: LotjaGi4g1v0331500 | 24 | ||
| – | ATP-citrate synthase, putative; TAIR: AT3G06650.1 ATP-citrate lyase B-1; Swiss-Prot: sp|Q93VT8|ACLB1_ORYSJ ATP-citrate synthase beta chain protein 1; TrEMBL-Plants: tr|A6MZ92|A6MZ92_GLYUR ATP citrate lyase alpha subunit; Found in the gene: LotjaGi4g1v0331500 | 24 | ||
| – | ATP-citrate synthase, putative; TAIR: AT3G06650.1 ATP-citrate lyase B-1; Swiss-Prot: sp|Q93VT8|ACLB1_ORYSJ ATP-citrate synthase beta chain protein 1; TrEMBL-Plants: tr|A6MZ92|A6MZ92_GLYUR ATP citrate lyase alpha subunit; Found in the gene: LotjaGi4g1v0331500 | 24 | ||
| – | Citrate synthase; TAIR: AT2G42790.1 citrate synthase 3; Swiss-Prot: sp|P49299|CYSZ_CUCMA Citrate synthase, glyoxysomal; TrEMBL-Plants: tr|G7IZY5|G7IZY5_MEDTR Citrate synthase; Found in the gene: LotjaGi6g1v0170700 | 14 | ||
| – | Citrate synthase; TAIR: AT2G42790.1 citrate synthase 3; Swiss-Prot: sp|P49299|CYSZ_CUCMA Citrate synthase, glyoxysomal; TrEMBL-Plants: tr|G7IZY5|G7IZY5_MEDTR Citrate synthase; Found in the gene: LotjaGi6g1v0170700 | 19 | ||
| – | Citrate synthase; TAIR: AT2G42790.1 citrate synthase 3; Swiss-Prot: sp|P49299|CYSZ_CUCMA Citrate synthase, glyoxysomal; TrEMBL-Plants: tr|A0A151RYN3|A0A151RYN3_CAJCA Citrate synthase; Found in the gene: LotjaGi6g1v0170700 | 15 | ||
| – | ATP-citrate synthase, putative; TAIR: AT3G06650.1 ATP-citrate lyase B-1; Swiss-Prot: sp|Q93VT8|ACLB1_ORYSJ ATP-citrate synthase beta chain protein 1; TrEMBL-Plants: tr|V7BMZ5|V7BMZ5_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0258800 | 24 | ||
| – | ATP-citrate synthase, putative; TAIR: AT3G06650.1 ATP-citrate lyase B-1; Swiss-Prot: sp|Q93VT8|ACLB1_ORYSJ ATP-citrate synthase beta chain protein 1; TrEMBL-Plants: tr|V7BMZ5|V7BMZ5_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0258800 | 24 | ||
| – | ATP-citrate synthase, putative; TAIR: AT3G06650.1 ATP-citrate lyase B-1; Swiss-Prot: sp|Q93VT8|ACLB1_ORYSJ ATP-citrate synthase beta chain protein 1; TrEMBL-Plants: tr|V7BMZ5|V7BMZ5_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0258800 | 24 | ||
| – | ATP-citrate synthase, putative; TAIR: AT3G06650.1 ATP-citrate lyase B-1; Swiss-Prot: sp|Q93VT8|ACLB1_ORYSJ ATP-citrate synthase beta chain protein 1; TrEMBL-Plants: tr|V7BMZ5|V7BMZ5_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0258800 | 22 | ||
| – | ATP-citrate synthase, putative; TAIR: AT3G06650.1 ATP-citrate lyase B-1; Swiss-Prot: sp|Q93VT8|ACLB1_ORYSJ ATP-citrate synthase beta chain protein 1; TrEMBL-Plants: tr|V7BMZ5|V7BMZ5_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0258800 | 24 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd06100 | CDD | 1 | 5.00 |