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IPR017071 is a Transcription elongation factor Spt5, eukaryote.
<p>This family consists of several eukaryotic transcription elongation Spt5 proteins. These proteins contain two copies of a domain (Supt5; [interpro:IPR005100]) that is characteristic of proteins involved in chromatin regulation. An NGN domain separates the Supt5 domains. In yeast Spt5 protein, this domain possesses a RNP-like fold and it is thought to confer affinity for Spt4 protein. Supt5 domains are followed by four to five copies of a KOW domain ([interpro:IPR005824]), present in many ribosomal proteins.</p> <p>Three transcription-elongation factors Spt4, Spt5, and Spt6 are conserved among eukaryotes and are essential for transcription via modulation of chromatin structure. Spt4 and Spt5 are tightly associated in a complex, while the physical association Spt6 is considerably weaker. It has been demonstrated that Spt4, Spt5, and Spt6 play roles in transcription elongation in both yeast and humans, including a role in activation by Tat. It is known that Spt4, Spt5, and Spt6 are general transcription-elongation factors, controlling transcription both positively and negatively in important regulatory and developmental roles [[cite:PUB00012261]].</p> <p>This information was partially derived from InterPro ([interpro:IPR009287]).</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. | ||
| Biological process | Regulation of DNA-templated transcription, elongation | Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Transcription elongation factor SPT5; TAIR: AT4G08350.1 global transcription factor group A2; Swiss-Prot: sp|Q9STN3|SPT51_ARATH Putative transcription elongation factor SPT5 homolog 1; TrEMBL-Plants: tr|I1JYX6|I1JYX6_SOYBN Transcription elongation factor SPT5; Found in the gene: LotjaGi1g1v0273000 | 37 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 100.00 |