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IPR041978

Source: InterPro

Description

IPR041978 is a Spt5, KOW domain repeat 5.

<p>Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C terminus. Spt5 is involved in transcription elongation and termination. The KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4 [[cite:PUB00005458]]. Unlike bacterial NusG with its single KOW motif, eukaryotic Spt5 has multiple KOW domains. There are four KOW motifs in yeast Spt5, whereas human Spt5 has six [[cite:PUB00092166]]. Spt5 KOW domains play critical roles in recruitment of multiple other eukaryotic transcription elongation and RNA biogenesis factors and additionally are involved in the binding of the eukaryotic Spt5 proteins to RNA polymerases [[cite:PUB00092162], [cite:PUB00061569], [cite:PUB00092163]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi1g1v0273000.1
– Transcription elongation factor SPT5; TAIR: AT4G08350.1 global transcription factor group A2; Swiss-Prot: sp|Q9STN3|SPT51_ARATH Putative transcription elongation factor SPT5 homolog 1; TrEMBL-Plants: tr|I1JYX6|I1JYX6_SOYBN Transcription elongation factor SPT5; Found in the gene: LotjaGi1g1v0273000
Domains
37

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 100.00