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IPR018451

Description

IPR018451 is a NAF/FISL domain.

<p>The NAF domain is a 24 amino acid domain that is found in a plant-specific subgroup of serine-threonine protein kinases (CIPKs), that interact with calcineurin B-like calcium sensor proteins (CBLs). Whereas the N-terminal part of CIPKs comprises a conserved catalytic domain typical of Ser-Thr kinases, the much less conserved C-terminal domain appears to be unique to this subgroup of kinases. The only exception is the NAF domain that forms an 'island of conservation' in this otherwise variable region. The NAF domain has been named after the prominent conserved amino acids Asn-Ala-Phe. It represents a minimum protein interaction module that is both necessary and sufficient to mediate the interaction with the CBL calcium sensor proteins [[cite:PUB00007298]].</p> <p>The secondary structure of the NAF domain is currently not known, but secondary structure computation of the C-terminal region of Arabidopsis thaliana CBL-interacting protein kinase 1 revealed a long helical structure [[cite:PUB00007298]].</p> <p>The NAF domain has also been named FISL motif for its conserved amino acid residues [[cite:PUB00018279]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Biological process Signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

Associated Lotus transcripts 76

Transcript Name Description Predicted domains Domain count
PREDICTED: CBL-interacting serine/threonine-protein kinase 10-like isoform X1 [Cicer arietinum] gi|502129560|ref|XP_004500345.1| 24
PREDICTED: CBL-interacting protein kinase 2-like isoform 2 [Glycine max] gi|356540040|ref|XP_003538499.1| 17
PREDICTED: CBL-interacting protein kinase 2-like isoform 1 [Glycine max] gi|356540038|ref|XP_003538498.1| 22
PREDICTED: CBL-interacting serine/threonine-protein kinase 1-like [Cicer arietinum] gi|502086342|ref|XP_004488187.1| 21
PREDICTED: CBL-interacting serine/threonine-protein kinase 25-like [Cicer arietinum] gi|502125148|ref|XP_004498818.1| 21
PREDICTED: CBL-interacting serine/threonine-protein kinase 7-like [Cicer arietinum] gi|502123125|ref|XP_004498005.1| 19
PREDICTED: CBL-interacting serine/threonine-protein kinase 11-like [Cicer arietinum] gi|502096347|ref|XP_004490706.1| 23
Ser/Thr protein kinase [Lotus japonicus] gi|62857008|dbj|BAD95889.1| 19
Ser/Thr protein kinase [Lotus japonicus] gi|62857008|dbj|BAD95889.1| 25
CBL-interacting protein kinase [Medicago truncatula] gi|357437095|ref|XP_003588823.1| 2
PREDICTED: CBL-interacting serine/threonine-protein kinase 11-like [Glycine max] gi|356566779|ref|XP_003551605.1| 19
PREDICTED: CBL-interacting serine/threonine-protein kinase 8-like [Glycine max] gi|356500781|ref|XP_003519209.1| 19
CBL-interacting protein kinase [Medicago truncatula] gi|357437095|ref|XP_003588823.1| 3
CBL-interacting protein kinase [Medicago truncatula] gi|357491433|ref|XP_003616004.1| 26
PREDICTED: CBL-interacting serine/threonine-protein kinase 14-like [Fragaria vesca subsp]. vesca] gi|470133437|ref|XP_004302572.1| 19
PREDICTED: CBL-interacting protein kinase 2-like [Glycine max] gi|356496299|ref|XP_003517006.1| 23
Ser/Thr protein kinase [Lotus japonicus] gi|62857018|dbj|BAD95894.1| 20
PREDICTED: CBL-interacting serine/threonine-protein kinase 9-like [Glycine max] gi|356560251|ref|XP_003548407.1| 21
Protein kinase [Phaseolus vulgaris] gi|166788439|dbj|BAG06675.1| 4
Ser/Thr protein kinase [Lotus japonicus] gi|62867351|dbj|BAD95978.1| 20
Protein kinase [Phaseolus vulgaris] gi|166788439|dbj|BAG06675.1| 21
PREDICTED: CBL-interacting serine/threonine-protein kinase 1-like [Glycine max] gi|356548027|ref|XP_003542405.1| 21
PREDICTED: CBL-interacting serine/threonine-protein kinase 1-like [Glycine max] gi|356548027|ref|XP_003542405.1| 21
PREDICTED: CBL-interacting serine/threonine-protein kinase 23-like [Glycine max] gi|356530563|ref|XP_003533850.1| 22
PREDICTED: CBL-interacting serine/threonine-protein kinase 12-like [Glycine max] gi|356510969|ref|XP_003524205.1| 25
PREDICTED: CBL-interacting serine/threonine-protein kinase 7-like [Glycine max] gi|356535343|ref|XP_003536206.1| 22
Ser/Thr protein kinase [Lotus japonicus] gi|62857010|dbj|BAD95890.1| 18
PREDICTED: CBL-interacting serine/threonine-protein kinase 25-like [Cicer arietinum] gi|502125148|ref|XP_004498818.1| 10
Protein kinase [Phaseolus vulgaris] gi|166788445|dbj|BAG06678.1| 22
PREDICTED: CBL-interacting serine/threonine-protein kinase 23-like [Glycine max] gi|356530563|ref|XP_003533850.1| 23
PREDICTED: CBL-interacting serine/threonine-protein kinase 23-like [Glycine max] gi|356530563|ref|XP_003533850.1| 23
PREDICTED: CBL-interacting serine/threonine-protein kinase 12-like [Glycine max] gi|356557753|ref|XP_003547175.1| 26
PREDICTED: CBL-interacting serine/threonine-protein kinase 20-like [Cicer arietinum] gi|502078321|ref|XP_004485907.1| 28
Non-specific serine/threonine protein kinase; TAIR: AT2G26980.3 CBL-interacting protein kinase 3; Swiss-Prot: sp|Q2V452|CIPK3_ARATH CBL-interacting serine/threonine-protein kinase 3; TrEMBL-Plants: tr|Q53VM3|Q53VM3_LOTJA Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi1g1v0054700 24
Non-specific serine/threonine protein kinase; TAIR: AT2G26980.3 CBL-interacting protein kinase 3; Swiss-Prot: sp|Q2V452|CIPK3_ARATH CBL-interacting serine/threonine-protein kinase 3; TrEMBL-Plants: tr|Q53VM3|Q53VM3_LOTJA Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi1g1v0054700 24
Non-specific serine/threonine protein kinase; TAIR: AT2G26980.4 CBL-interacting protein kinase 3; Swiss-Prot: sp|Q2V452|CIPK3_ARATH CBL-interacting serine/threonine-protein kinase 3; TrEMBL-Plants: tr|Q53VM3|Q53VM3_LOTJA Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi1g1v0054700 24
Non-specific serine/threonine protein kinase; TAIR: AT2G26980.3 CBL-interacting protein kinase 3; Swiss-Prot: sp|Q2V452|CIPK3_ARATH CBL-interacting serine/threonine-protein kinase 3; TrEMBL-Plants: tr|Q53VM3|Q53VM3_LOTJA Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi1g1v0054700 24
CBL-interacting Serine/Threonine-kinase; TAIR: AT2G30360.1 SOS3-interacting protein 4; Swiss-Prot: sp|O22932|CIPKB_ARATH CBL-interacting serine/threonine-protein kinase 11; TrEMBL-Plants: tr|G7K0R1|G7K0R1_MEDTR Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi1g1v0107900 23
Non-specific serine/threonine protein kinase; TAIR: AT5G58380.1 SOS3-interacting protein 1; Swiss-Prot: sp|Q9C562|CIPKA_ARATH CBL-interacting serine/threonine-protein kinase 10; TrEMBL-Plants: tr|A0A0B2S9N6|A0A0B2S9N6_GLYSO Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi1g1v0108000 23
Non-specific serine/threonine protein kinase; TAIR: AT4G24400.1 CBL-interacting protein kinase 8; Swiss-Prot: sp|Q9STV4|CIPK8_ARATH CBL-interacting serine/threonine-protein kinase 8; TrEMBL-Plants: tr|I3S1E9|I3S1E9_LOTJA Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi1g1v0134300 20
Non-specific serine/threonine protein kinase; TAIR: AT4G24400.1 CBL-interacting protein kinase 8; Swiss-Prot: sp|Q9STV4|CIPK8_ARATH CBL-interacting serine/threonine-protein kinase 8; TrEMBL-Plants: tr|I3S1E9|I3S1E9_LOTJA Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi1g1v0134300 20
Non-specific serine/threonine protein kinase; TAIR: AT4G24400.1 CBL-interacting protein kinase 8; Swiss-Prot: sp|Q9STV4|CIPK8_ARATH CBL-interacting serine/threonine-protein kinase 8; TrEMBL-Plants: tr|I3S1E9|I3S1E9_LOTJA Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi1g1v0134300 17
Non-specific serine/threonine protein kinase; TAIR: AT4G24400.1 CBL-interacting protein kinase 8; Swiss-Prot: sp|Q9STV4|CIPK8_ARATH CBL-interacting serine/threonine-protein kinase 8; TrEMBL-Plants: tr|I3S1E9|I3S1E9_LOTJA Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi1g1v0134300 18
Non-specific serine/threonine protein kinase; TAIR: AT4G24400.1 CBL-interacting protein kinase 8; Swiss-Prot: sp|Q9STV4|CIPK8_ARATH CBL-interacting serine/threonine-protein kinase 8; TrEMBL-Plants: tr|I3S1E9|I3S1E9_LOTJA Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi1g1v0134300 11
Non-specific serine/threonine protein kinase; TAIR: AT5G25110.1 CBL-interacting protein kinase 25; Swiss-Prot: sp|Q8W1D5|CIPKP_ARATH CBL-interacting serine/threonine-protein kinase 25; TrEMBL-Plants: tr|G7I7M2|G7I7M2_MEDTR Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi1g1v0301900_LC 2
Non-specific serine/threonine protein kinase; TAIR: AT5G10930.1 CBL-interacting protein kinase 5; Swiss-Prot: sp|Q9LEU7|CIPK5_ARATH CBL-interacting serine/threonine-protein kinase 5; TrEMBL-Plants: tr|G7I7M2|G7I7M2_MEDTR Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi1g1v0345400_LC 3
Non-specific serine/threonine protein kinase; TAIR: AT4G24400.1 CBL-interacting protein kinase 8; Swiss-Prot: sp|Q9STV4|CIPK8_ARATH CBL-interacting serine/threonine-protein kinase 8; TrEMBL-Plants: tr|Q53VM2|Q53VM2_LOTJA Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi1g1v0414900 21
Non-specific serine/threonine protein kinase; TAIR: AT5G58380.1 SOS3-interacting protein 1; Swiss-Prot: sp|Q7X996|CIPK2_ORYSJ CBL-interacting protein kinase 2; TrEMBL-Plants: tr|I1N370|I1N370_SOYBN Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi1g1v0454100 25
Non-specific serine/threonine protein kinase; TAIR: AT5G58380.1 SOS3-interacting protein 1; Swiss-Prot: sp|Q7X996|CIPK2_ORYSJ CBL-interacting protein kinase 2; TrEMBL-Plants: tr|I1N370|I1N370_SOYBN Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi1g1v0454100 25
Non-specific serine/threonine protein kinase; TAIR: AT2G30360.1 SOS3-interacting protein 4; Swiss-Prot: sp|O22932|CIPKB_ARATH CBL-interacting serine/threonine-protein kinase 11; TrEMBL-Plants: tr|V7B2N8|V7B2N8_PHAVU Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi1g1v0454600 20
Non-specific serine/threonine protein kinase; TAIR: AT5G10930.1 CBL-interacting protein kinase 5; Swiss-Prot: sp|Q9LEU7|CIPK5_ARATH CBL-interacting serine/threonine-protein kinase 5; TrEMBL-Plants: tr|Q53VD9|Q53VD9_LOTJA Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi3g1v0004300 23
Non-specific serine/threonine protein kinase; TAIR: AT5G58380.1 SOS3-interacting protein 1; Swiss-Prot: sp|Q7X996|CIPK2_ORYSJ CBL-interacting protein kinase 2; TrEMBL-Plants: tr|I1J7N3|I1J7N3_SOYBN Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi3g1v0094200 24
Non-specific serine/threonine protein kinase; TAIR: AT5G58380.1 SOS3-interacting protein 1; Swiss-Prot: sp|Q7X996|CIPK2_ORYSJ CBL-interacting protein kinase 2; TrEMBL-Plants: tr|I1J7N3|I1J7N3_SOYBN Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi3g1v0094200 24
Non-specific serine/threonine protein kinase; TAIR: AT5G10930.1 CBL-interacting protein kinase 5; Swiss-Prot: sp|Q9LEU7|CIPK5_ARATH CBL-interacting serine/threonine-protein kinase 5; TrEMBL-Plants: tr|Q53VE1|Q53VE1_LOTJA Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi3g1v0350000 19
Non-specific serine/threonine protein kinase; TAIR: AT1G01140.1 CBL-interacting protein kinase 9; Swiss-Prot: sp|Q9MAM1|CIPK9_ARATH CBL-interacting serine/threonine-protein kinase 9; TrEMBL-Plants: tr|I1MKE2|I1MKE2_SOYBN Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi3g1v0401800 20
Non-specific serine/threonine protein kinase; TAIR: AT1G01140.3 CBL-interacting protein kinase 9; Swiss-Prot: sp|Q9MAM1|CIPK9_ARATH CBL-interacting serine/threonine-protein kinase 9; TrEMBL-Plants: tr|I1KHQ8|I1KHQ8_SOYBN Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi3g1v0401800 20
Non-specific serine/threonine protein kinase; TAIR: AT5G35410.1 Protein kinase superfamily protein; Swiss-Prot: sp|Q9LDI3|CIPKO_ARATH CBL-interacting serine/threonine-protein kinase 24; TrEMBL-Plants: tr|Q53UK3|Q53UK3_LOTJA Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi4g1v0272000 21
Non-specific serine/threonine protein kinase; TAIR: AT4G30960.1 SOS3-interacting protein 3; Swiss-Prot: sp|O65554|CIPK6_ARATH CBL-interacting serine/threonine-protein kinase 6; TrEMBL-Plants: tr|A0A0L9TQR6|A0A0L9TQR6_PHAAN Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi4g1v0287000 22
Non-specific serine/threonine protein kinase; TAIR: AT4G30960.1 SOS3-interacting protein 3; Swiss-Prot: sp|O65554|CIPK6_ARATH CBL-interacting serine/threonine-protein kinase 6; TrEMBL-Plants: tr|A0A0L9TQR6|A0A0L9TQR6_PHAAN Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi4g1v0287000 22
Non-specific serine/threonine protein kinase; TAIR: AT4G30960.1 SOS3-interacting protein 3; Swiss-Prot: sp|O65554|CIPK6_ARATH CBL-interacting serine/threonine-protein kinase 6; TrEMBL-Plants: tr|A0A0L9TQR6|A0A0L9TQR6_PHAAN Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi4g1v0287000 20
Non-specific serine/threonine protein kinase; TAIR: AT5G57630.1 CBL-interacting protein kinase 21; Swiss-Prot: sp|Q94CG0|CIPKL_ARATH CBL-interacting serine/threonine-protein kinase 21; TrEMBL-Plants: tr|G7JD36|G7JD36_MEDTR Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi4g1v0297500 20
Non-specific serine/threonine protein kinase; TAIR: AT3G17510.1 CBL-interacting protein kinase 1; Swiss-Prot: sp|Q8RWC9|CIPK1_ARATH CBL-interacting serine/threonine-protein kinase 1; TrEMBL-Plants: tr|I1LYG0|I1LYG0_SOYBN Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi4g1v0313800 20
Non-specific serine/threonine protein kinase; TAIR: AT4G18700.1 CBL-interacting protein kinase 12; Swiss-Prot: sp|Q9SN43|CIPKC_ARATH CBL-interacting serine/threonine-protein kinase 12; TrEMBL-Plants: tr|A0A0L9TK21|A0A0L9TK21_PHAAN Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi4g1v0378200 24
Non-specific serine/threonine protein kinase; TAIR: AT5G10930.1 CBL-interacting protein kinase 5; Swiss-Prot: sp|Q9LEU7|CIPK5_ARATH CBL-interacting serine/threonine-protein kinase 5; TrEMBL-Plants: tr|A0A061GJK6|A0A061GJK6_THECC Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi5g1v0050900 21
Non-specific serine/threonine protein kinase; TAIR: AT5G58380.1 SOS3-interacting protein 1; Swiss-Prot: sp|Q7X996|CIPK2_ORYSJ CBL-interacting protein kinase 2; TrEMBL-Plants: tr|K7LRS9|K7LRS9_SOYBN Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi6g1v0083300 20
Non-specific serine/threonine protein kinase; TAIR: AT5G58380.1 SOS3-interacting protein 1; Swiss-Prot: sp|Q7X996|CIPK2_ORYSJ CBL-interacting protein kinase 2; TrEMBL-Plants: tr|K7LRS9|K7LRS9_SOYBN Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi6g1v0083300 20
Non-specific serine/threonine protein kinase; TAIR: AT5G58380.1 SOS3-interacting protein 1; Swiss-Prot: sp|Q9C562|CIPKA_ARATH CBL-interacting serine/threonine-protein kinase 10; TrEMBL-Plants: tr|V7BP93|V7BP93_PHAVU Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi6g1v0104500 23
Non-specific serine/threonine protein kinase; TAIR: AT5G58380.1 SOS3-interacting protein 1; Swiss-Prot: sp|Q9C562|CIPKA_ARATH CBL-interacting serine/threonine-protein kinase 10; TrEMBL-Plants: tr|V7BP93|V7BP93_PHAVU Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi6g1v0104500 23
Non-specific serine/threonine protein kinase; TAIR: AT4G30960.1 SOS3-interacting protein 3; Swiss-Prot: sp|O65554|CIPK6_ARATH CBL-interacting serine/threonine-protein kinase 6; TrEMBL-Plants: tr|V7AXV8|V7AXV8_PHAVU Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi6g1v0204400 22
Non-specific serine/threonine protein kinase; TAIR: AT4G30960.1 SOS3-interacting protein 3; Swiss-Prot: sp|O65554|CIPK6_ARATH CBL-interacting serine/threonine-protein kinase 6; TrEMBL-Plants: tr|V7AXV8|V7AXV8_PHAVU Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi6g1v0204400 21
Non-specific serine/threonine protein kinase; TAIR: AT1G30270.1 CBL-interacting protein kinase 23; Swiss-Prot: sp|Q93VD3|CIPKN_ARATH CBL-interacting serine/threonine-protein kinase 23; TrEMBL-Plants: tr|A0A0R4J3Z4|A0A0R4J3Z4_SOYBN Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi6g1v0210400 24
Non-specific serine/threonine protein kinase; TAIR: AT3G17510.1 CBL-interacting protein kinase 1; Swiss-Prot: sp|Q8RWC9|CIPK1_ARATH CBL-interacting serine/threonine-protein kinase 1; TrEMBL-Plants: tr|I1L1Y4|I1L1Y4_SOYBN Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi6g1v0217400 21
Non-specific serine/threonine protein kinase; TAIR: AT3G17510.1 CBL-interacting protein kinase 1; Swiss-Prot: sp|Q8RWC9|CIPK1_ARATH CBL-interacting serine/threonine-protein kinase 1; TrEMBL-Plants: tr|A0A0R0I5F3|A0A0R0I5F3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0217400 16
Non-specific serine/threonine protein kinase; TAIR: AT4G18700.1 CBL-interacting protein kinase 12; Swiss-Prot: sp|Q9SN43|CIPKC_ARATH CBL-interacting serine/threonine-protein kinase 12; TrEMBL-Plants: tr|I3SMH8|I3SMH8_LOTJA Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi6g1v0321800 25
Non-specific serine/threonine protein kinase; TAIR: AT4G18700.1 CBL-interacting protein kinase 12; Swiss-Prot: sp|Q9SN43|CIPKC_ARATH CBL-interacting serine/threonine-protein kinase 12; TrEMBL-Plants: tr|I3SMH8|I3SMH8_LOTJA Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi6g1v0321800 25
Non-specific serine/threonine protein kinase; TAIR: AT4G18700.1 CBL-interacting protein kinase 12; Swiss-Prot: sp|Q9SN43|CIPKC_ARATH CBL-interacting serine/threonine-protein kinase 12; TrEMBL-Plants: tr|I3SMH8|I3SMH8_LOTJA Non-specific serine/threonine protein kinase; Found in the gene: LotjaGi6g1v0321800 22

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 1.32