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IPR019805 is a Heat shock protein Hsp90, conserved site.
<p>Prokaryotes and eukaryotes respond to heat shock and other forms of environmental stress by inducing synthesis of heat-shock proteins (hsp) [[cite:PUB00000102]]. The 90kDa heat shock protein, Hsp90, is one of the most abundant proteins in eukaryotic cells, comprising 1-2% of cellular proteins under non-stress conditions [[cite:PUB00014968]]. Its contribution to various cellular processes including signal transduction, protein folding, protein degradation and morphological evolution has been extensively studied [[cite:PUB00002788], [cite:PUB00005421]]. The full functional activity of Hsp90 is gained in concert with other co-chaperones, playing an important role in the folding of newly synthesised proteins and stabilisation and refolding of denatured proteins after stress. Apart from its co-chaperones, Hsp90 binds to an array of client proteins, where the co-chaperone requirement varies and depends on the actual client.</p> <p>The sequences of hsp90s show a distinctive domain structure, with a highly-conserved N-terminal domain separated from a conserved, acidic C-terminal domain by a highly-acidic, flexible linker region.</p> <p>The signature pattern for the hsp90 family of proteins is located in a highly conserved region found in the N-terminal part of these proteins.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Biological process | Protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. | ||
| Molecular function | Unfolded protein binding | Interacting selectively and non-covalently with an unfolded protein. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: heat shock protein 83-like [Glycine max] gi|356530818|ref|XP_003533977.1| | 21 | ||
| – | PREDICTED: heat shock protein 83-like [Glycine max] gi|356499958|ref|XP_003518802.1| | 19 | ||
| – | PREDICTED: heat shock cognate protein 80-like [Vitis vinifera] gi|359495606|ref|XP_003635036.1| | 21 | ||
| – | Heat-shock protein [Medicago truncatula] gi|357495325|ref|XP_003617951.1| | 20 | ||
| – | Heat-shock protein [Medicago truncatula] gi|357495325|ref|XP_003617951.1| | 20 | ||
| – | PREDICTED: endoplasmin homolog [Glycine max] gi|356553371|ref|XP_003545030.1| | 29 | ||
| – | Heat shock protein 90 [Vitis pseudoreticulata] gi|159459822|gb|ABW96308.1| | 21 | ||
| – | Chaperone protein htpG family protein; TAIR: AT3G07770.1 HEAT SHOCK PROTEIN 89.1; Swiss-Prot: sp|F4JFN3|HS906_ARATH Heat shock protein 90-6, mitochondrial; TrEMBL-Plants: tr|A0A151S032|A0A151S032_CAJCA Heat shock protein 90; Found in the gene: LotjaGi1g1v0009000 | 26 | ||
| – | Chaperone protein htpG family protein; TAIR: AT3G07770.1 HEAT SHOCK PROTEIN 89.1; Swiss-Prot: sp|F4JFN3|HS906_ARATH Heat shock protein 90-6, mitochondrial; TrEMBL-Plants: tr|A0A151S032|A0A151S032_CAJCA Heat shock protein 90; Found in the gene: LotjaGi1g1v0009000 | 25 | ||
| – | Chaperone protein htpG family protein; TAIR: AT3G07770.1 HEAT SHOCK PROTEIN 89.1; Swiss-Prot: sp|F4JFN3|HS906_ARATH Heat shock protein 90-6, mitochondrial; TrEMBL-Plants: tr|A0A151S032|A0A151S032_CAJCA Heat shock protein 90; Found in the gene: LotjaGi1g1v0009000 | 25 | ||
| – | Heat shock protein 90; TAIR: AT5G56000.1 HEAT SHOCK PROTEIN 81.4; Swiss-Prot: sp|P36181|HSP80_SOLLC Heat shock cognate protein 80; TrEMBL-Plants: tr|F6HCU9|F6HCU9_VITVI Putative uncharacterized protein; Found in the gene: LotjaGi1g1v0013800 | 27 | ||
| – | Heat shock protein 90; TAIR: AT5G56000.1 HEAT SHOCK PROTEIN 81.4; Swiss-Prot: sp|P36181|HSP80_SOLLC Heat shock cognate protein 80; TrEMBL-Plants: tr|F6HCU9|F6HCU9_VITVI Putative uncharacterized protein; Found in the gene: LotjaGi1g1v0013800 | 27 | ||
| – | Chaperone protein htpG family protein; TAIR: AT5G56000.1 HEAT SHOCK PROTEIN 81.4; Swiss-Prot: sp|Q69QQ6|HSP82_ORYSJ Heat shock protein 81-2; TrEMBL-Plants: tr|B6EBD7|B6EBD7_SOYBN Heat shock protein 90-1; Found in the gene: LotjaGi1g1v0013800 | 26 | ||
| – | Heat shock protein 90; TAIR: AT5G56000.1 HEAT SHOCK PROTEIN 81.4; Swiss-Prot: sp|P36181|HSP80_SOLLC Heat shock cognate protein 80; TrEMBL-Plants: tr|F6HCU9|F6HCU9_VITVI Putative uncharacterized protein; Found in the gene: LotjaGi1g1v0013800 | 27 | ||
| – | Heat shock protein 90; TAIR: AT5G52640.1 heat shock-like protein; Swiss-Prot: sp|P51819|HSP83_IPONI Heat shock protein 83; TrEMBL-Plants: tr|I1L314|I1L314_SOYBN Heat shock protein 90-1; Found in the gene: LotjaGi2g1v0124300 | 27 | ||
| – | Chaperone protein htpG family protein; TAIR: AT5G52640.1 heat shock-like protein; Swiss-Prot: sp|P51819|HSP83_IPONI Heat shock protein 83; TrEMBL-Plants: tr|I1L314|I1L314_SOYBN Heat shock protein 90-1; Found in the gene: LotjaGi2g1v0124300 | 26 | ||
| – | Heat shock protein 90; TAIR: AT5G52640.1 heat shock-like protein; Swiss-Prot: sp|P51819|HSP83_IPONI Heat shock protein 83; TrEMBL-Plants: tr|I1L314|I1L314_SOYBN Heat shock protein 90-1; Found in the gene: LotjaGi2g1v0124300 | 27 | ||
| – | Chaperone protein htpG family protein; TAIR: AT2G04030.1 Chaperone protein htpG family protein; Swiss-Prot: sp|Q9SIF2|HS905_ARATH Heat shock protein 90-5, chloroplastic; TrEMBL-Plants: tr|A0A072TVH5|A0A072TVH5_MEDTR Heat shock protein 81-2; Found in the gene: LotjaGi2g1v0289600 | 26 | ||
| – | Chaperone protein htpG family protein; TAIR: AT2G04030.1 Chaperone protein htpG family protein; Swiss-Prot: sp|Q9SIF2|HS905_ARATH Heat shock protein 90-5, chloroplastic; TrEMBL-Plants: tr|A0A072TVH5|A0A072TVH5_MEDTR Heat shock protein 81-2; Found in the gene: LotjaGi2g1v0289600 | 26 | ||
| – | Chaperone protein htpG family protein; TAIR: AT2G04030.1 Chaperone protein htpG family protein; Swiss-Prot: sp|Q9SIF2|HS905_ARATH Heat shock protein 90-5, chloroplastic; TrEMBL-Plants: tr|A0A0L9UT74|A0A0L9UT74_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0289600 | 27 | ||
| – | Chaperone protein htpG family protein; TAIR: AT4G24190.1 Chaperone protein htpG family protein; Swiss-Prot: sp|P35016|ENPL_CATRO Endoplasmin homolog; TrEMBL-Plants: tr|I1MC32|I1MC32_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0005000 | 33 | ||
| – | Heat shock protein 90; TAIR: AT5G52640.1 heat shock-like protein; Swiss-Prot: sp|P51819|HSP83_IPONI Heat shock protein 83; TrEMBL-Plants: tr|A0A0A0L6P6|A0A0A0L6P6_CUCSA Uncharacterized protein; Found in the gene: LotjaGi5g1v0296600 | 27 | ||
| – | Chaperone protein htpG family protein; TAIR: AT5G52640.1 heat shock-like protein; Swiss-Prot: sp|P51819|HSP83_IPONI Heat shock protein 83; TrEMBL-Plants: tr|A0A0V0IQG0|A0A0V0IQG0_SOLCH Putative heat shock protein 83-like; Found in the gene: LotjaGi5g1v0296600 | 24 | ||
| – | Chaperone protein htpG family protein; TAIR: AT5G52640.1 heat shock-like protein; Swiss-Prot: sp|P51819|HSP83_IPONI Heat shock protein 83; TrEMBL-Plants: tr|Q71EE1|Q71EE1_HEVBR Heat shock protein; Found in the gene: LotjaGi5g1v0296600 | 23 | ||
| – | Heat shock protein 90; TAIR: AT5G56000.1 HEAT SHOCK PROTEIN 81.4; Swiss-Prot: sp|P36181|HSP80_SOLLC Heat shock cognate protein 80; TrEMBL-Plants: tr|T2AUM9|T2AUM9_POPTO HSP90; Found in the gene: LotjaGi6g1v0139700 | 27 | ||
| – | Chaperone protein htpG family protein; TAIR: AT5G56000.1 HEAT SHOCK PROTEIN 81.4; Swiss-Prot: sp|Q69QQ6|HSP82_ORYSJ Heat shock protein 81-2; TrEMBL-Plants: tr|A0A0D2SEK3|A0A0D2SEK3_GOSRA Uncharacterized protein; Found in the gene: LotjaGi6g1v0139700 | 26 | ||
| – | Heat shock protein 90; TAIR: AT5G56000.1 HEAT SHOCK PROTEIN 81.4; Swiss-Prot: sp|P36181|HSP80_SOLLC Heat shock cognate protein 80; TrEMBL-Plants: tr|D6C500|D6C500_SOYBN HSP90-2; Found in the gene: LotjaGi6g1v0139700 | 27 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 3.70 |