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IPR020596

Source: InterPro

Description

IPR020596 is a Ribosomal RNA adenine methylase transferase, conserved site.

<p>This entry represents a highly conserved region located in the N-terminal section that is probably involved in S-adenosyl methionine (SAM) binding.</p> <p>The bacterial enzyme KsgA catalyses the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases in 16S rRNA. This enzyme and the resulting modified adenosine bases appear to be conserved in all species of eubacteria, eukaryotes, and archaea, and in eukaryotic organelles. Bacterial resistance to the aminoglycoside antibiotic kasugamycin involves inactivation of KsgA and resulting loss of the dimethylations, with modest consequences to the overall fitness of the organism [[cite:PUB00101504], [cite:PUB00101503], [cite:PUB00101505]]. In contrast, the yeast ortholog, Dim1, is essential. In Saccharomyces cerevisiae (Baker's yeast), and presumably in other eukaryotes, the enzyme performs a vital role in pre-rRNA processing in addition to its methylating activity [[cite:PUB00014820]]. Another orthologue is the eukaryotic transcription factor B (TFB), which has a second function; this enzyme is a nuclear-encoded mitochondrial transcription factor and is essential for mitochondrial gene expression [[cite:PUB00072555]]. The best conserved region in these enzymes is located in the N-terminal section and corresponds to a region that is probably involved in S-adenosyl methionine (SAM) binding domain.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0000154
Biological process RRNA modification The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically.
Subterm of
GO:0000179
Molecular function RRNA (adenine-N6,N6-)-dimethyltransferase activity Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor.
Subterm of
GO:0008649
Molecular function RRNA methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule.
Subterm of

Associated Lotus transcripts 6

Transcript Name Description Predicted domains Domain count
Lj1g3v2624830.1
– PREDICTED: ribosomal RNA small subunit methyltransferase A-like [Glycine max] gi|356568329|ref|XP_003552364.1|
Domains
16
Lj3g3v0807650.1
– Dimethyladenosine transferase [Medicago truncatula] gi|357455725|ref|XP_003598143.1|
Domains
16
LotjaGi1g1v0469600.1
– Ribosomal RNA small subunit methyltransferase A; TAIR: AT1G01860.1 Ribosomal RNA adenine dimethylase family protein; Swiss-Prot: sp|O65090|DIM1C_ARATH Ribosomal RNA small subunit methyltransferase, chloroplastic; TrEMBL-Plants: tr|I1N3K9|I1N3K9_SOYBN rRNA adenine N(6)-methyltransferase; Found in the gene: LotjaGi1g1v0469600
Domains
16
LotjaGi2g1v0385600.1
– Ribosomal RNA small subunit methyltransferase A; TAIR: AT5G66360.2 Ribosomal RNA adenine dimethylase family protein; Swiss-Prot: sp|Q9FK02|DIM1B_ARATH Ribosomal RNA small subunit methyltransferase, mitochondrial; TrEMBL-Plants: tr|G7KGB1|G7KGB1_MEDTR rRNA adenine N(6)-methyltransferase; Found in the gene: LotjaGi2g1v0385600
Domains
17
LotjaGi3g1v0100100.1
– Ribosomal rna small subunit methyltransferase; TAIR: AT2G47420.1 Ribosomal RNA adenine dimethylase family protein; Swiss-Prot: sp|O22268|DIM1A_ARATH Ribosomal RNA small subunit methyltransferase; TrEMBL-Plants: tr|A0A1J7H0M5|A0A1J7H0M5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0100100
Domains
17
LotjaGi3g1v0100100.2
– Ribosomal rna small subunit methyltransferase; TAIR: AT2G47420.1 Ribosomal RNA adenine dimethylase family protein; Swiss-Prot: sp|O22268|DIM1A_ARATH Ribosomal RNA small subunit methyltransferase; TrEMBL-Plants: tr|A0A1J7H0M5|A0A1J7H0M5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0100100
Domains
17

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 16.67