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IPR024936

Source: InterPro

Description

IPR024936 is a Cyclophilin-type peptidyl-prolyl cis-trans isomerase.

<p>Cyclophilins exhibit peptidyl-prolyl cis-trans isomerase (PPIase) activity ([ec:5.2.1.8]), accelerating protein folding by catalysing the cis-trans isomerisation of proline imidic peptide bonds in oligopeptides [[cite:PUB00017852], [cite:PUB00000320]]. They also have protein chaperone-like functions [[cite:PUB00021063]] and are the major high-affinity binding proteins for the immunosuppressive drug cyclosporin A (CSA) in vertebrates [[cite:PUB00017852]].</p> <p>Cyclophilins are found in all prokaryotes and eukaryotes, and have been structurally conserved throughout evolution, implying their importance in cellular function [[cite:PUB00056846]]. They share a common 109 amino acid cyclophilin-like domain (CLD) and additional domains unique to each member of the family. The CLD domain contains the PPIase activity, while the unique domains are important for selection of protein substrates and subcellular compartmentalisation [[cite:PUB00056847]].</p> <p>This entry represents the cyclophilin peptidyl-prolyl cis-trans isomerase family. The family includes RING-type E3 ubiquitin-protein ligase PPIL2, which is thought to be an inactive PPIase [[cite:PUB00089651]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003755
Molecular function Peptidyl-prolyl cis-trans isomerase activity Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
Subterm of

Associated Lotus transcripts 39

Transcript Name Description Predicted domains Domain count
Lj0g3v0018479.1
– PREDICTED: peptidyl-prolyl cis-trans isomerase CYP20-1-like [Cicer arietinum] gi|502129296|ref|XP_004500254.1|
Domains
9
Lj0g3v0018489.1
– PREDICTED: peptidyl-prolyl cis-trans isomerase CYP20-1-like [Cicer arietinum] gi|502129296|ref|XP_004500254.1|
Domains
11
Lj0g3v0212469.1
– PREDICTED: peptidyl-prolyl cis-trans isomerase CYP40-like [Glycine max] gi|356511742|ref|XP_003524582.1|
Domains
21
Lj0g3v0215839.1
– PREDICTED: peptidyl-prolyl cis-trans isomerase CYP37, chloroplastic-like isoform X1 [Cicer arietinum] gi|502168275|ref|XP_004514351.1|
Domains
9
Lj0g3v0254699.1
– PREDICTED: peptidyl-prolyl cis-trans isomerase CWC27 homolog [Cicer arietinum] gi|502079117|ref|XP_004486160.1|
Domains
13
Lj0g3v0254699.2
– PREDICTED: peptidyl-prolyl cis-trans isomerase CWC27 homolog [Cicer arietinum] gi|502079117|ref|XP_004486160.1|
Domains
13
Lj0g3v0286639.1
– PREDICTED: peptidyl-prolyl cis-trans isomerase-like 4-like isoform X1 [Cicer arietinum] gi|502124034|ref|XP_004498355.1|
Domains
14
Lj0g3v0286639.2
– Peptidyl-prolyl cis-trans isomerase [Medicago truncatula] gi|358345178|ref|XP_003636659.1|
Domains
18
Lj0g3v0312029.1
– PREDICTED: peptidyl-prolyl cis-trans isomerase-like 4-like isoform X2 [Cicer arietinum] gi|502124036|ref|XP_004498356.1|
Domains
17
Lj0g3v0347429.1
– Peptidyl-prolyl cis-trans isomerase [Medicago truncatula] gi|357461217|ref|XP_003600890.1|
Domains
17
Lj1g3v1384110.1
– PREDICTED: peptidyl-prolyl cis-trans isomerase CYP40-like [Glycine max] gi|356521481|ref|XP_003529384.1|
Domains
23
Lj1g3v1912840.1
– PREDICTED: serine/arginine repetitive matrix protein 2-like isoform X2 [Cicer arietinum] gi|502124749|ref|XP_004498656.1|
Domains
11
Lj1g3v3343880.1
– PREDICTED: peptidyl-prolyl cis-trans isomerase-like [Cicer arietinum] gi|502130706|ref|XP_004500742.1|
Domains
14
Lj1g3v4719660.1
– PREDICTED: peptidyl-prolyl cis-trans isomerase-like 1-like [Cicer arietinum] gi|502111994|ref|XP_004494215.1|
Domains
10
Lj1g3v4719660.2
– PREDICTED: peptidyl-prolyl cis-trans isomerase-like 1-like [Cicer arietinum] gi|502111994|ref|XP_004494215.1|
Domains
13
Lj1g3v4820020.1
– PREDICTED: LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase, chloroplastic-like [Glycine max] gi|356505701|ref|XP_003521628.1|
Domains
13
Lj2g3v1014320.1
– PREDICTED: peptidyl-prolyl cis-trans isomerase CYP38, chloroplastic-like [Glycine max] gi|356571435|ref|XP_003553882.1|
Domains
12
Lj2g3v1014320.2
– PREDICTED: peptidyl-prolyl cis-trans isomerase CYP38, chloroplastic-like [Glycine max] gi|356571435|ref|XP_003553882.1|
Domains
19
Lj2g3v1242230.1
– PREDICTED: peptidyl-prolyl cis-trans isomerase E-like [Solanum lycopersicum] gi|460382667|ref|XP_004237059.1|
Domains
12
Lj2g3v1296290.1
– PREDICTED: probable peptidyl-prolyl cis-trans isomerase-like isoform X2 [Cicer arietinum] gi|502093698|ref|XP_004490023.1|
Domains
19
Lj2g3v1968380.1
– PREDICTED: peptidyl-prolyl cis-trans isomerase-like 2-like isoform X3 [Cicer arietinum] gi|502160668|ref|XP_004511839.1|
Domains
14
Lj3g3v1145930.1
– PREDICTED: peptidylprolyl isomerase domain and WD repeat-containing protein 1-like isoform X2 [Cicer arietinum] gi|502083631|ref|XP_004487517.1|
Domains
23
Lj3g3v1906510.1
– PREDICTED: peptidyl-prolyl cis-trans isomerase H-like [Cicer arietinum] gi|502158162|ref|XP_004511051.1|
Domains
14
Lj3g3v1906510.2
– Peptidyl-prolyl cis-trans isomerase [Medicago truncatula] gi|357515287|ref|XP_003627932.1|
Domains
10
Lj3g3v2723670.1
– Peptidyl-prolyl cis-trans isomerase [Medicago truncatula] gi|358344345|ref|XP_003636250.1|
Domains
13
Lj3g3v3527420.1
– PREDICTED: peptidyl-prolyl cis-trans isomerase 1-like [Glycine max] gi|356507991|ref|XP_003522746.1|
Domains
14
Lj3g3v3527430.1
– PREDICTED: peptidyl-prolyl cis-trans isomerase isoform 1 [Vitis vinifera] gi|225457957|ref|XP_002274869.1|
Domains
14
Lj4g3v1784850.1
– PREDICTED: peptidyl-prolyl cis-trans isomerase B-like [Glycine max] gi|356563117|ref|XP_003549812.1|
Domains
10
Lj5g3v1793380.1
– PREDICTED: peptidyl-prolyl cis-trans isomerase CYP21-3, mitochondrial-like isoform X1 [Cicer arietinum] gi|502118339|ref|XP_004496218.1|
Domains
15
Lj6g3v1088970.1
– PREDICTED: peptidyl-prolyl cis-trans isomerase B-like [Glycine max] gi|356556583|ref|XP_003546604.1|
Domains
12
LotjaGi1g1v0560400.1
– Peptidyl-prolyl cis-trans isomerase; TAIR: AT2G16600.1 rotamase CYP 3; Swiss-Prot: sp|Q8W171|CYP1_SOYBN Peptidyl-prolyl cis-trans isomerase 1; TrEMBL-Plants: tr|K7LSN8|K7LSN8_SOYBN Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi1g1v0560400
Domains
14
LotjaGi1g1v0733700.1
– Peptidyl-prolyl cis-trans isomerase; TAIR: AT2G36130.1 Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q9SIH1|CP18B_ARATH Peptidyl-prolyl cis-trans isomerase CYP18-2; TrEMBL-Plants: tr|I3T4L8|I3T4L8_LOTJA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi1g1v0733700
Domains
14
LotjaGi1g1v0733700.2
– Peptidyl-prolyl cis-trans isomerase; TAIR: AT2G36130.1 Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q9SIH1|CP18B_ARATH Peptidyl-prolyl cis-trans isomerase CYP18-2; TrEMBL-Plants: tr|I3T4L8|I3T4L8_LOTJA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi1g1v0733700
Domains
13
LotjaGi1g1v0785800.2
– Peptidyl-prolyl cis-trans isomerase; TAIR: AT3G56070.1 rotamase cyclophilin 2; Swiss-Prot: sp|Q38867|CP19C_ARATH Peptidyl-prolyl cis-trans isomerase CYP19-3; TrEMBL-Plants: tr|I3SVV5|I3SVV5_LOTJA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi1g1v0785800
Domains
14
LotjaGi3g1v0316100.1
– Peptidyl-prolyl cis-trans isomerase; TAIR: AT2G38730.1 Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q9ZVJ4|CYP22_ARATH Peptidyl-prolyl cis-trans isomerase CYP22; TrEMBL-Plants: tr|I3S0I8|I3S0I8_LOTJA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi3g1v0316100
Domains
14
LotjaGi3g1v0431500.1
– Peptidyl-prolyl cis-trans isomerase; TAIR: AT1G01940.1 Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q9LPC7|CP18A_ARATH Peptidyl-prolyl cis-trans isomerase CYP18-1; TrEMBL-Plants: tr|I3T5E6|I3T5E6_LOTJA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi3g1v0431500
Domains
14
LotjaGi3g1v0530700.1
– Peptidyl-prolyl cis-trans isomerase; TAIR: AT4G38740.1 rotamase CYP 1; Swiss-Prot: sp|Q8W171|CYP1_SOYBN Peptidyl-prolyl cis-trans isomerase 1; TrEMBL-Plants: tr|I3STY8|I3STY8_LOTJA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi3g1v0530700
Domains
14
LotjaGi3g1v0530900.1
– Peptidyl-prolyl cis-trans isomerase; TAIR: AT2G16600.1 rotamase CYP 3; Swiss-Prot: sp|Q39613|CYPH_CATRO Peptidyl-prolyl cis-trans isomerase; TrEMBL-Plants: tr|A9PJ47|A9PJ47_9ROSI Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi3g1v0530900
Domains
14
LotjaGi6g1v0113500.1
– Peptidyl-prolyl cis-trans isomerase; TAIR: AT2G29960.1 cyclophilin 5; Swiss-Prot: sp|Q8LDP4|CP19D_ARATH Peptidyl-prolyl cis-trans isomerase CYP19-4; TrEMBL-Plants: tr|I3SFD4|I3SFD4_LOTJA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi6g1v0113500
Domains
21

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd01926 CDD 1 2.56