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IPR002130

Description

IPR002130 is a Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain.

<p>Cyclophilins exhibit peptidyl-prolyl cis-trans isomerase (PPIase) activity ([ec:5.2.1.8]), accelerating protein folding by catalysing the cis-trans isomerisation of proline imidic peptide bonds in oligopeptides [[cite:PUB00017852], [cite:PUB00000320]]. They also have protein chaperone-like functions [[cite:PUB00021063]] and are the major high-affinity binding proteins for the immunosuppressive drug cyclosporin A (CSA) in vertebrates [[cite:PUB00017852]].</p> <p>Cyclophilins are found in all prokaryotes and eukaryotes, and have been structurally conserved throughout evolution, implying their importance in cellular function [[cite:PUB00056846]]. They share a common 109 amino acid cyclophilin-like domain (CLD) and additional domains unique to each member of the family. The CLD domain contains the PPIase activity, while the unique domains are important for selection of protein substrates and subcellular compartmentalisation [[cite:PUB00056847]].</p> <p>This entry represents the core β-barrel cyclophilin-like domain.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Biological process Protein peptidyl-prolyl isomerization The modification of a protein by cis-trans isomerization of a proline residue.
Molecular function Peptidyl-prolyl cis-trans isomerase activity Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).

Associated Lotus transcripts 69

Transcript Name Description Predicted domains Domain count
PREDICTED: peptidyl-prolyl cis-trans isomerase CYP20-1-like [Cicer arietinum] gi|502129296|ref|XP_004500254.1| 9
PREDICTED: peptidyl-prolyl cis-trans isomerase CYP20-1-like [Cicer arietinum] gi|502129296|ref|XP_004500254.1| 11
PREDICTED: peptidyl-prolyl cis-trans isomerase CYP40-like [Glycine max] gi|356511742|ref|XP_003524582.1| 21
PREDICTED: peptidyl-prolyl cis-trans isomerase CYP37, chloroplastic-like isoform X1 [Cicer arietinum] gi|502168275|ref|XP_004514351.1| 9
PREDICTED: peptidyl-prolyl cis-trans isomerase CWC27 homolog [Cicer arietinum] gi|502079117|ref|XP_004486160.1| 13
PREDICTED: peptidyl-prolyl cis-trans isomerase CWC27 homolog [Cicer arietinum] gi|502079117|ref|XP_004486160.1| 13
PREDICTED: peptidyl-prolyl cis-trans isomerase-like 4-like isoform X1 [Cicer arietinum] gi|502124034|ref|XP_004498355.1| 14
PREDICTED: peptidyl-prolyl cis-trans isomerase-like 4-like isoform X2 [Cicer arietinum] gi|502124036|ref|XP_004498356.1| 17
Peptidyl-prolyl cis-trans isomerase [Medicago truncatula] gi|357461217|ref|XP_003600890.1| 17
PREDICTED: peptidyl-prolyl cis-trans isomerase CYP40-like [Glycine max] gi|356521481|ref|XP_003529384.1| 23
PREDICTED: serine/arginine repetitive matrix protein 2-like isoform X2 [Cicer arietinum] gi|502124749|ref|XP_004498656.1| 11
Peptidyl-prolyl cis-trans isomerase, cyclophilin type [Medicago truncatula] gi|124359489|gb|ABN05927.1| 12
PREDICTED: peptidyl-prolyl cis-trans isomerase-like [Cicer arietinum] gi|502130706|ref|XP_004500742.1| 14
PREDICTED: peptidyl-prolyl cis-trans isomerase-like 1-like [Cicer arietinum] gi|502111994|ref|XP_004494215.1| 10
PREDICTED: peptidyl-prolyl cis-trans isomerase-like 1-like [Cicer arietinum] gi|502111994|ref|XP_004494215.1| 13
PREDICTED: LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase, chloroplastic-like [Glycine max] gi|356505701|ref|XP_003521628.1| 13
PREDICTED: peptidyl-prolyl cis-trans isomerase CYP38, chloroplastic-like [Glycine max] gi|356571435|ref|XP_003553882.1| 19
PREDICTED: probable peptidyl-prolyl cis-trans isomerase-like isoform X2 [Cicer arietinum] gi|502093698|ref|XP_004490023.1| 19
PREDICTED: peptidyl-prolyl cis-trans isomerase-like 2-like isoform X3 [Cicer arietinum] gi|502160668|ref|XP_004511839.1| 14
Peptidyl-prolyl cis-trans isomerases isoform 1 [Theobroma cacao] gi|508776905|gb|EOY24161.1| 12
PREDICTED: peptidylprolyl isomerase domain and WD repeat-containing protein 1-like isoform X2 [Cicer arietinum] gi|502083631|ref|XP_004487517.1| 23
PREDICTED: peptidyl-prolyl cis-trans isomerase H-like [Cicer arietinum] gi|502158162|ref|XP_004511051.1| 14
Peptidyl-prolyl cis-trans isomerase [Medicago truncatula] gi|357515287|ref|XP_003627932.1| 10
Peptidyl-prolyl cis-trans isomerase [Medicago truncatula] gi|358344345|ref|XP_003636250.1| 13
PREDICTED: peptidyl-prolyl cis-trans isomerase 1-like [Glycine max] gi|356507991|ref|XP_003522746.1| 14
PREDICTED: peptidyl-prolyl cis-trans isomerase isoform 1 [Vitis vinifera] gi|225457957|ref|XP_002274869.1| 14
PREDICTED: peptidyl-prolyl cis-trans isomerase B-like [Glycine max] gi|356563117|ref|XP_003549812.1| 10
PREDICTED: peptidyl-prolyl cis-trans isomerase CYP21-3, mitochondrial-like isoform X1 [Cicer arietinum] gi|502118339|ref|XP_004496218.1| 15
PREDICTED: peptidyl-prolyl cis-trans isomerase B-like [Glycine max] gi|356556583|ref|XP_003546604.1| 12
Peptidyl-prolyl cis-trans isomerase; TAIR: AT2G15790.1 peptidyl-prolyl cis-trans isomerase / cyclophilin-40 (CYP40) / rotamase; Swiss-Prot: sp|Q9C566|CYP40_ARATH Peptidyl-prolyl cis-trans isomerase CYP40; TrEMBL-Plants: tr|I3SXT9|I3SXT9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0329100 22
Peptidyl-prolyl cis-trans isomerase; TAIR: AT2G15790.1 peptidyl-prolyl cis-trans isomerase / cyclophilin-40 (CYP40) / rotamase; Swiss-Prot: sp|Q9C566|CYP40_ARATH Peptidyl-prolyl cis-trans isomerase CYP40; TrEMBL-Plants: tr|I3SXT9|I3SXT9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0329100 22
Peptidyl-prolyl cis-trans isomerase; TAIR: AT4G32420.4 Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q8RWY7|CYP95_ARATH Peptidyl-prolyl cis-trans isomerase CYP95; TrEMBL-Plants: tr|A0A0R0GCC6|A0A0R0GCC6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0386100 10
Peptidyl-prolyl cis-trans isomerase; TAIR: AT4G17070.1 peptidyl-prolyl cis-trans isomerase; Swiss-Prot: sp|Q5ZLV2|PPIL3_CHICK Peptidyl-prolyl cis-trans isomerase-like 3; TrEMBL-Plants: tr|A0A1J7GE52|A0A1J7GE52_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0492400 13
Peptidyl-prolyl cis-trans isomerase; TAIR: AT2G16600.1 rotamase CYP 3; Swiss-Prot: sp|Q8W171|CYP1_SOYBN Peptidyl-prolyl cis-trans isomerase 1; TrEMBL-Plants: tr|K7LSN8|K7LSN8_SOYBN Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi1g1v0560400 14
Peptidyl-prolyl cis-trans isomerase; TAIR: AT3G63400.1 Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q9LY75|CYP63_ARATH Peptidyl-prolyl cis-trans isomerase CYP63; TrEMBL-Plants: tr|A0A151SJ02|A0A151SJ02_CAJCA 40 kDa peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi1g1v0715100 13
Peptidyl-prolyl cis-trans isomerase; TAIR: AT2G36130.1 Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q9SIH1|CP18B_ARATH Peptidyl-prolyl cis-trans isomerase CYP18-2; TrEMBL-Plants: tr|I3T4L8|I3T4L8_LOTJA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi1g1v0733700 14
Peptidyl-prolyl cis-trans isomerase; TAIR: AT2G36130.1 Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q9SIH1|CP18B_ARATH Peptidyl-prolyl cis-trans isomerase CYP18-2; TrEMBL-Plants: tr|I3T4L8|I3T4L8_LOTJA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi1g1v0733700 13
Peptidyl-prolyl cis-trans isomerase; TAIR: AT3G62030.1 rotamase CYP 4; Swiss-Prot: sp|Q41651|CYPB_VICFA Peptidyl-prolyl cis-trans isomerase, chloroplastic; TrEMBL-Plants: tr|I3SRL0|I3SRL0_LOTJA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi1g1v0753600 9
Peptidyl-prolyl cis-trans isomerase; TAIR: AT3G56070.1 rotamase cyclophilin 2; Swiss-Prot: sp|Q38867|CP19C_ARATH Peptidyl-prolyl cis-trans isomerase CYP19-3; TrEMBL-Plants: tr|I3SVV5|I3SVV5_LOTJA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi1g1v0785800 12
Peptidyl-prolyl cis-trans isomerase; TAIR: AT3G56070.1 rotamase cyclophilin 2; Swiss-Prot: sp|Q38867|CP19C_ARATH Peptidyl-prolyl cis-trans isomerase CYP19-3; TrEMBL-Plants: tr|I3SVV5|I3SVV5_LOTJA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi1g1v0785800 14
Peptidyl-prolyl cis-trans isomerase, putative; TAIR: AT3G01480.1 cyclophilin 38; Swiss-Prot: sp|Q9SSA5|CYP38_ARATH Peptidyl-prolyl cis-trans isomerase CYP38, chloroplastic; TrEMBL-Plants: tr|B9RUU4|B9RUU4_RICCO Peptidyl-prolyl cis-trans isomerase, putative; Found in the gene: LotjaGi2g1v0247600 9
Peptidyl-prolyl cis-trans isomerase; TAIR: AT3G01480.1 cyclophilin 38; Swiss-Prot: sp|Q9SSA5|CYP38_ARATH Peptidyl-prolyl cis-trans isomerase CYP38, chloroplastic; TrEMBL-Plants: tr|A0A151QQR2|A0A151QQR2_CAJCA Uncharacterized protein; Found in the gene: LotjaGi2g1v0247600 13
Peptidyl-prolyl cis-trans isomerase, putative; TAIR: AT3G01480.1 cyclophilin 38; Swiss-Prot: sp|Q9SSA5|CYP38_ARATH Peptidyl-prolyl cis-trans isomerase CYP38, chloroplastic; TrEMBL-Plants: tr|B9RUU4|B9RUU4_RICCO Peptidyl-prolyl cis-trans isomerase, putative; Found in the gene: LotjaGi2g1v0247600 9
Peptidyl-prolyl cis-trans isomerase; TAIR: AT3G01480.1 cyclophilin 38; Swiss-Prot: sp|Q9SSA5|CYP38_ARATH Peptidyl-prolyl cis-trans isomerase CYP38, chloroplastic; TrEMBL-Plants: tr|A0A151QQR2|A0A151QQR2_CAJCA Uncharacterized protein; Found in the gene: LotjaGi2g1v0247600 19
Peptidyl-prolyl cis-trans isomerase; TAIR: AT3G01480.1 cyclophilin 38; Swiss-Prot: sp|Q9SSA5|CYP38_ARATH Peptidyl-prolyl cis-trans isomerase CYP38, chloroplastic; TrEMBL-Plants: tr|A0A151QQR2|A0A151QQR2_CAJCA Uncharacterized protein; Found in the gene: LotjaGi2g1v0247600 19
Peptidyl-prolyl cis-trans isomerase; TAIR: AT1G26940.1 Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q8LDR3|CYP23_ARATH Peptidyl-prolyl cis-trans isomerase CYP23; TrEMBL-Plants: tr|V7CHS7|V7CHS7_PHAVU Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi2g1v0306300 16
Peptidyl-prolyl cis-trans isomerase; TAIR: AT1G26940.2 Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q8LDR3|CYP23_ARATH Peptidyl-prolyl cis-trans isomerase CYP23; TrEMBL-Plants: tr|B7FMU5|B7FMU5_MEDTR Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi2g1v0306300 9
Peptidyl-prolyl cis-trans isomerase; TAIR: AT1G26940.2 Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q8LDR3|CYP23_ARATH Peptidyl-prolyl cis-trans isomerase CYP23; TrEMBL-Plants: tr|B7FMU5|B7FMU5_MEDTR Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi2g1v0306300 9
Peptidyl-prolyl cis-trans isomerase-like protein; TAIR: AT5G67530.1 plant U-box 49; Swiss-Prot: sp|Q9FJX0|PPIL2_ARATH Peptidyl-prolyl cis-trans isomerase CYP65; TrEMBL-Plants: tr|A0A151SC33|A0A151SC33_CAJCA Peptidyl-prolyl cis-trans isomerase-like 2; Found in the gene: LotjaGi2g1v0409700 21
Peptidyl-prolyl cis-trans isomerase; TAIR: AT4G17070.1 peptidyl-prolyl cis-trans isomerase; Swiss-Prot: sp|P52017|CYP10_CAEEL Peptidyl-prolyl cis-trans isomerase 10; TrEMBL-Plants: tr|I1LGV6|I1LGV6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0418700 13
Peptidyl-prolyl cis-trans isomerase, putative; TAIR: AT3G44600.1 cyclophilin71; Swiss-Prot: sp|Q8W4D0|CPY71_ARATH Peptidyl-prolyl cis-trans isomerase CYP71; TrEMBL-Plants: tr|I1M4E9|I1M4E9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0174700 23
Peptidyl-prolyl cis-trans isomerase-like protein; TAIR: AT1G53720.1 cyclophilin 59; Swiss-Prot: sp|Q6Q151|CYP59_ARATH Peptidyl-prolyl cis-trans isomerase CYP59; TrEMBL-Plants: tr|A0A072U025|A0A072U025_MEDTR Peptidyl-prolyl cis-trans isomerase-like protein; Found in the gene: LotjaGi3g1v0299600 28
Peptidyl-prolyl cis-trans isomerase; TAIR: AT2G38730.1 Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q9ZVJ4|CYP22_ARATH Peptidyl-prolyl cis-trans isomerase CYP22; TrEMBL-Plants: tr|I3S0I8|I3S0I8_LOTJA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi3g1v0316100 14
Peptidyl-prolyl cis-trans isomerase; TAIR: AT2G38730.1 Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q9ZVJ4|CYP22_ARATH Peptidyl-prolyl cis-trans isomerase CYP22; TrEMBL-Plants: tr|I3T602|I3T602_LOTJA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi3g1v0316100 11
Peptidyl-prolyl cis-trans isomerase; TAIR: AT3G15520.1 Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|P82869|CYP37_ARATH Peptidyl-prolyl cis-trans isomerase CYP37, chloroplastic; TrEMBL-Plants: tr|A0A072U108|A0A072U108_MEDTR Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi3g1v0321400 9
Peptidyl-prolyl cis-trans isomerase; TAIR: AT1G01940.1 Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q9LPC7|CP18A_ARATH Peptidyl-prolyl cis-trans isomerase CYP18-1; TrEMBL-Plants: tr|I3T5E6|I3T5E6_LOTJA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi3g1v0431500 14
Peptidyl-prolyl cis-trans isomerase; TAIR: AT4G38740.1 rotamase CYP 1; Swiss-Prot: sp|Q8W171|CYP1_SOYBN Peptidyl-prolyl cis-trans isomerase 1; TrEMBL-Plants: tr|I3STY8|I3STY8_LOTJA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi3g1v0530700 14
Peptidyl-prolyl cis-trans isomerase; TAIR: AT2G16600.1 rotamase CYP 3; Swiss-Prot: sp|Q39613|CYPH_CATRO Peptidyl-prolyl cis-trans isomerase; TrEMBL-Plants: tr|A9PJ47|A9PJ47_9ROSI Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi3g1v0530900 14
Peptidyl-prolyl cis-trans isomerase; TAIR: AT2G15790.1 peptidyl-prolyl cis-trans isomerase / cyclophilin-40 (CYP40) / rotamase; Swiss-Prot: sp|Q9C566|CYP40_ARATH Peptidyl-prolyl cis-trans isomerase CYP40; TrEMBL-Plants: tr|A0A0L9TGI2|A0A0L9TGI2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0107700 20
Peptidyl-prolyl cis-trans isomerase; TAIR: AT1G74070.1 Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|F4HTT6|CP26B_ARATH Peptidyl-prolyl cis-trans isomerase CYP26-2, chloroplastic; TrEMBL-Plants: tr|I1K194|I1K194_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0262400 8
Peptidyl-prolyl cis-trans isomerase; TAIR: AT4G33060.1 Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q6Q152|CPY57_ARATH Peptidyl-prolyl cis-trans isomerase CYP57; TrEMBL-Plants: tr|A0A151RT99|A0A151RT99_CAJCA Peptidyl-prolyl cis-trans isomerase SDCCAG10; Found in the gene: LotjaGi5g1v0048200 12
Peptidyl-prolyl cis-trans isomerase; TAIR: AT3G62030.3 rotamase CYP 4; Swiss-Prot: sp|Q41651|CYPB_VICFA Peptidyl-prolyl cis-trans isomerase, chloroplastic; TrEMBL-Plants: tr|I3SD90|I3SD90_LOTJA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi5g1v0236400 13
Peptidyl-prolyl cis-trans isomerase; TAIR: AT3G66654.1 Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q9C835|CP21D_ARATH Peptidyl-prolyl cis-trans isomerase CYP21-4; TrEMBL-Plants: tr|I3T1I5|I3T1I5_LOTJA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi5g1v0269300 14
Peptidyl-prolyl cis-trans isomerase; TAIR: AT3G66654.1 Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q9C835|CP21D_ARATH Peptidyl-prolyl cis-trans isomerase CYP21-4; TrEMBL-Plants: tr|I3T1I5|I3T1I5_LOTJA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi5g1v0269300 9
Peptidyl-prolyl cis-trans isomerase; TAIR: AT5G13120.1 cyclophilin 20-2; Swiss-Prot: sp|Q9ASS6|PNSL5_ARATH Photosynthetic NDH subunit of lumenal location 5, chloroplastic; TrEMBL-Plants: tr|M5XGJ2|M5XGJ2_PRUPE Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi5g1v0366000 17
Peptidyl-prolyl cis-trans isomerase; TAIR: AT5G13120.1 cyclophilin 20-2; Swiss-Prot: sp|Q9ASS6|PNSL5_ARATH Photosynthetic NDH subunit of lumenal location 5, chloroplastic; TrEMBL-Plants: tr|A0A068V0G9|A0A068V0G9_COFCA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi5g1v0366000 9
Peptidyl-prolyl cis-trans isomerase; TAIR: AT5G58710.1 rotamase CYP 7; Swiss-Prot: sp|Q9SP02|CP20A_ARATH Peptidyl-prolyl cis-trans isomerase CYP20-1; TrEMBL-Plants: tr|I3SDU9|I3SDU9_LOTJA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi6g1v0074600 16
Peptidyl-prolyl cis-trans isomerase; TAIR: AT2G29960.1 cyclophilin 5; Swiss-Prot: sp|Q8LDP4|CP19D_ARATH Peptidyl-prolyl cis-trans isomerase CYP19-4; TrEMBL-Plants: tr|I3SFD4|I3SFD4_LOTJA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi6g1v0113500 21
Peptidyl-prolyl cis-trans isomerase; TAIR: AT5G35100.1 Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|O65220|CPY28_ARATH Peptidyl-prolyl cis-trans isomerase CYP28, chloroplastic; TrEMBL-Plants: tr|I1MI02|I1MI02_SOYBN Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi6g1v0207700 10

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd00317 CDD 1 1.45