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IPR032642 is a DNA mismatch repair protein Msh2, ATP-binding cassette domain.
<p>This entry represents the DNA mismatch repair protein Msh2 (homologous to bacterial MutS) from eukaryotes. Msh2-Msh6 complex recognises base pair mismatches and small insertion/deletions in DNA and initiates repair [[cite:PUB00076557]]. Human Msh2-Msh6 complex has been shown to regulate BLM helicase in response to the damaged DNA forks during double-stranded break repair [[cite:PUB00076559]].</p> <p>Mismatch repair (MMR) is one of five major DNA repair pathways. The mismatch repair system recognises and repairs mispaired or unpaired nucleotides that result from errors in DNA replication. The most extensively studied general MMR system is the MutHLS pathway of the bacterium Escherichia coli. In the first step of the MutHLS pathway, the MutS protein (in the form of a dimer) binds to the site of a mismatch in double-stranded DNA. Through a complex interaction between MutS, MutL and MutH, a section of the newly replicated DNA strand (and thus the strand with the replication error) at the location of the mismatch bound by MutS is targeted for removal [[cite:PUB00004486]]. Homologues of MutS have been found in many species including eukaryotes, Archaea and other bacteria, and together these proteins have been grouped into the MutS family.</p> <p>This entry represents the ATP-binding cassette domain of Msh2.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Biological process | Mismatch repair | A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. | ||
| Cellular component | Mismatch repair complex | Any complex formed of proteins that act in mismatch repair. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: DNA mismatch repair protein Msh2-like [Glycine max] gi|356563103|ref|XP_003549805.1| | 25 | ||
| – | PREDICTED: DNA mismatch repair protein MSH2-like [Cicer arietinum] gi|502151706|ref|XP_004508573.1| | 11 | ||
| – | DNA mismatch repair protein mutS; TAIR: AT3G18524.1 MUTS homolog 2; Swiss-Prot: sp|O24617|MSH2_ARATH DNA mismatch repair protein MSH2; TrEMBL-Plants: tr|I1MUG2|I1MUG2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0263800 | 30 | ||
| – | DNA mismatch repair protein mutS; TAIR: AT3G18524.1 MUTS homolog 2; Swiss-Prot: sp|O24617|MSH2_ARATH DNA mismatch repair protein MSH2; TrEMBL-Plants: tr|I1MUG2|I1MUG2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0263800 | 26 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd03285 | CDD | 1 | 25.00 |