Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR007861 is a DNA mismatch repair protein MutS, clamp.
<p>Mismatch repair contributes to the overall fidelity of DNA replication and is essential for combating the adverse effects of damage to the genome. It involves the correction of mismatched base pairs that have been missed by the proofreading element of the DNA polymerase complex. The post-replicative Mismatch Repair System (MMRS) of Escherichia coli involves MutS (Mutator S), MutL and MutH proteins, and acts to correct point mutations or small insertion/deletion loops produced during DNA replication [[cite:PUB00042612]]. MutS and MutL are involved in preventing recombination between partially homologous DNA sequences. The assembly of MMRS is initiated by MutS, which recognises and binds to mispaired nucleotides and allows further action of MutL and MutH to eliminate a portion of newly synthesized DNA strand containing the mispaired base [[cite:PUB00042613]]. MutS can also collaborate with methyltransferases in the repair of O(6)-methylguanine damage, which would otherwise pair with thymine during replication to create an O(6)mG:T mismatch [[cite:PUB00042614]]. MutS exists as a dimer, where the two monomers have different conformations and form a heterodimer at the structural level [[cite:PUB00042218]]. Only one monomer recognises the mismatch specifically and has ADP bound. Non-specific major groove DNA-binding domains from both monomers embrace the DNA in a clamp-like structure. Mismatch binding induces ATP uptake and a conformational change in the MutS protein, resulting in a clamp that translocates on DNA.</p> <p>This entry represents the clamp domain (domain 4) found in proteins of the MutS family. The clamp domain is inserted within the core domain at the top of the lever helices. It has a β-sheet structure [[cite:PUB00010189]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Biological process | Mismatch repair | A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. | ||
| Molecular function | Mismatched DNA binding | Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: DNA mismatch repair protein MSH6-like [Cicer arietinum] gi|502112702|ref|XP_004494416.1| | 15 | ||
| – | PREDICTED: mutS protein homolog 4-like [Glycine max] gi|356540540|ref|XP_003538746.1| | 9 | ||
| – | PREDICTED: DNA mismatch repair protein Msh2-like [Glycine max] gi|356563103|ref|XP_003549805.1| | 25 | ||
| – | DNA mismatch repair protein MutS; TAIR: AT3G20475.1 MUTS-homologue 5; Swiss-Prot: sp|F4JEP5|MSH5_ARATH DNA mismatch repair protein MSH5; TrEMBL-Plants: tr|K7M4I0|K7M4I0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0027200 | 20 | ||
| – | DNA mismatch repair protein MutS; TAIR: AT3G20475.1 MUTS-homologue 5; Swiss-Prot: sp|F4JEP5|MSH5_ARATH DNA mismatch repair protein MSH5; TrEMBL-Plants: tr|K7M4I0|K7M4I0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0027200 | 20 | ||
| – | DNA mismatch repair protein MutS; TAIR: AT4G02070.1 MUTS homolog 6; Swiss-Prot: sp|O04716|MSH6_ARATH DNA mismatch repair protein MSH6; TrEMBL-Plants: tr|A0A151RYF4|A0A151RYF4_CAJCA DNA mismatch repair protein Msh6-1; Found in the gene: LotjaGi1g1v0760200 | 35 | ||
| – | DNA mismatch repair protein mutS; TAIR: AT4G17380.1 MUTS-like protein 4; Swiss-Prot: sp|F4JP48|MSH4_ARATH DNA mismatch repair protein MSH4; TrEMBL-Plants: tr|K7LMU8|K7LMU8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0421600 | 23 | ||
| – | DNA mismatch repair protein mutS, putative; TAIR: AT4G17380.1 MUTS-like protein 4; Swiss-Prot: sp|F4JP48|MSH4_ARATH DNA mismatch repair protein MSH4; TrEMBL-Plants: tr|A0A151TJF2|A0A151TJF2_CAJCA MutS protein isogeny 4; Found in the gene: LotjaGi2g1v0421600 | 20 | ||
| – | DNA mismatch repair protein mutS; TAIR: AT4G17380.2 MUTS-like protein 4; Swiss-Prot: sp|F4JP48|MSH4_ARATH DNA mismatch repair protein MSH4; TrEMBL-Plants: tr|A0A0R0HJU3|A0A0R0HJU3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0421600 | 23 | ||
| – | DNA mismatch repair protein mutS; TAIR: AT4G17380.1 MUTS-like protein 4; Swiss-Prot: sp|F4JP48|MSH4_ARATH DNA mismatch repair protein MSH4; TrEMBL-Plants: tr|K7LMU8|K7LMU8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0421600 | 23 | ||
| – | DNA mismatch repair protein mutS; TAIR: AT4G17380.2 MUTS-like protein 4; Swiss-Prot: sp|F4JP48|MSH4_ARATH DNA mismatch repair protein MSH4; TrEMBL-Plants: tr|A0A0R0HJU3|A0A0R0HJU3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0421600 | 23 | ||
| – | DNA mismatch repair protein mutS; TAIR: AT3G18524.1 MUTS homolog 2; Swiss-Prot: sp|O24617|MSH2_ARATH DNA mismatch repair protein MSH2; TrEMBL-Plants: tr|I1MUG2|I1MUG2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0263800 | 30 | ||
| – | DNA mismatch repair protein mutS; TAIR: AT3G18524.1 MUTS homolog 2; Swiss-Prot: sp|O24617|MSH2_ARATH DNA mismatch repair protein MSH2; TrEMBL-Plants: tr|I1MUG2|I1MUG2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0263800 | 26 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd03285 | CDD | 1 | 7.69 |