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IPR011184 is a DNA mismatch repair Msh2-type.
<p>Mismatch repair (MMR) is one of five major DNA repair pathways, the others being homologous recombination repair, non-homologous end joining, nucleotide excision repair, and base excision repair. The mismatch repair system recognises and repairs mispaired or unpaired nucleotides that result from errors in DNA replication. The most extensively studied general MMR system is the MutHLS pathway of the bacterium Escherichia coli. In the first step of the MutHLS pathway, the MutS protein (in the form of a dimer) binds to the site of a mismatch in double-stranded DNA. Through a complex interaction between MutS, MutL and MutH, a section of the newly replicated DNA strand (and thus the strand with the replication error) at the location of the mismatch bound by MutS is targeted for removal [[cite:PUB00004486]]. Homologues of MutS have been found in many species including eukaryotes, Archaea and other bacteria, and together these proteins have been grouped into the MutS family.</p> <p>This entry represents a subset of the MutS family members, including Msh2. Msh2 (MutS homologue 2) has a dual role in DNA repair and apoptosis. Msh2 acts as a heterodimer with Msh6, which together function to recruit the Mlh (MutL homologue) - Pms (post-meiotic segregation) heterodimer, and to replace the mispaired base [[cite:PUB00014545]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Biological process | Mismatch repair | A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. | ||
| Molecular function | Mismatched DNA binding | Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: DNA mismatch repair protein Msh2-like [Glycine max] gi|356563103|ref|XP_003549805.1| | 25 | ||
| – | DNA mismatch repair protein MutS; TAIR: AT3G20475.1 MUTS-homologue 5; Swiss-Prot: sp|F4JEP5|MSH5_ARATH DNA mismatch repair protein MSH5; TrEMBL-Plants: tr|K7M4I0|K7M4I0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0027200 | 20 | ||
| – | DNA mismatch repair protein MutS; TAIR: AT3G20475.1 MUTS-homologue 5; Swiss-Prot: sp|F4JEP5|MSH5_ARATH DNA mismatch repair protein MSH5; TrEMBL-Plants: tr|K7M4I0|K7M4I0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0027200 | 20 | ||
| – | DNA mismatch repair protein mutS; TAIR: AT4G17380.1 MUTS-like protein 4; Swiss-Prot: sp|F4JP48|MSH4_ARATH DNA mismatch repair protein MSH4; TrEMBL-Plants: tr|K7LMU8|K7LMU8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0421600 | 23 | ||
| – | DNA mismatch repair protein mutS, putative; TAIR: AT4G17380.1 MUTS-like protein 4; Swiss-Prot: sp|F4JP48|MSH4_ARATH DNA mismatch repair protein MSH4; TrEMBL-Plants: tr|A0A151TJF2|A0A151TJF2_CAJCA MutS protein isogeny 4; Found in the gene: LotjaGi2g1v0421600 | 20 | ||
| – | DNA mismatch repair protein mutS; TAIR: AT4G17380.2 MUTS-like protein 4; Swiss-Prot: sp|F4JP48|MSH4_ARATH DNA mismatch repair protein MSH4; TrEMBL-Plants: tr|A0A0R0HJU3|A0A0R0HJU3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0421600 | 23 | ||
| – | DNA mismatch repair protein mutS; TAIR: AT4G17380.2 MUTS-like protein 4; Swiss-Prot: sp|F4JP48|MSH4_ARATH DNA mismatch repair protein MSH4; TrEMBL-Plants: tr|A0A0R0HJU3|A0A0R0HJU3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0421600 | 23 | ||
| – | DNA mismatch repair protein mutS; TAIR: AT3G18524.1 MUTS homolog 2; Swiss-Prot: sp|O24617|MSH2_ARATH DNA mismatch repair protein MSH2; TrEMBL-Plants: tr|I1MUG2|I1MUG2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0263800 | 30 | ||
| – | DNA mismatch repair protein mutS; TAIR: AT3G18524.1 MUTS homolog 2; Swiss-Prot: sp|O24617|MSH2_ARATH DNA mismatch repair protein MSH2; TrEMBL-Plants: tr|I1MUG2|I1MUG2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0263800 | 26 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd03285 | CDD | 1 | 11.11 |