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IPR033690 is a Adenylate kinase, conserved site.
<p>Adenylate kinase (EC 2.7.4.3) (AK) [[cite:PUB00000992]] is a small monomeric enzyme that catalyzes the reversible transfer of MgATP to AMP (MgATP + AMP = MgADP + ADP).</p> <p>In mammals there are three different isozymes:</p> <ul> <li>AK1 (or myokinase), which is cytosolic.</li> <li>AK2, which is located in the outer compartment of mitochondria.</li> <li>AK3 (or GTP:AMP phosphotransferase), which is located in the mitochondrial matrix and which uses MgGTP instead of MgATP.</li> </ul> <p>The sequence of AK has also been obtained from different bacterial species and from plants and fungi.</p> <p>Two other enzymes have been found to be evolutionary related to AK. These are:</p> <ul> <li>Yeast uridylate kinase (EC 2.7.4.-) (UK) (gene URA6) [[cite:PUB00000188]] which catalyzes the transfer of a phosphate group from ATP to UMP to form UDP and ADP.</li> <li>Slime mold UMP-CMP kinase (EC 2.7.4.14) [[cite:PUB00002614]] which catalyzes the transfer of a phosphate group from ATP to either CMP or UMP to form CDP or UDP and ADP.</li> </ul> <p>Several regions of AK family enzymes are well conserved, including the ATP- binding domains. This entry represents a conserved site that includes an aspartic acid residue that is part of the catalytic cleft of the enzyme and that is involved in a salt bridge. It also includes an arginine residue whose modification leads to inactivation of the enzyme.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: adenylate kinase B-like [Glycine max] gi|356513991|ref|XP_003525691.1| | 16 | ||
| – | PREDICTED: probable adenylate kinase 1, chloroplastic-like [Cicer arietinum] gi|502166858|ref|XP_004513998.1| | 11 | ||
| – | PREDICTED: probable adenylate kinase 1, chloroplastic-like [Cicer arietinum] gi|502111015|ref|XP_004493934.1| | 15 | ||
| – | PREDICTED: UMP/CMP kinase-like isoform X2 [Cicer arietinum] gi|502155651|ref|XP_004510144.1| | 15 | ||
| – | PREDICTED: adenylate kinase-like isoform X4 [Cicer arietinum] gi|502146789|ref|XP_004506608.1| | 15 | ||
| – | PREDICTED: adenylate kinase-like isoform X4 [Cicer arietinum] gi|502146789|ref|XP_004506608.1| | 12 | ||
| – | PREDICTED: adenylate kinase-like isoform X4 [Cicer arietinum] gi|502146789|ref|XP_004506608.1| | 15 | ||
| – | PREDICTED: probable adenylate kinase 2, chloroplastic-like [Cicer arietinum] gi|502146257|ref|XP_004506372.1| | 14 | ||
| – | PREDICTED: adenylate kinase B-like [Glycine max] gi|356513991|ref|XP_003525691.1| | 16 | ||
| – | Adenylate kinase family protein isoform 1 [Theobroma cacao] gi|508784072|gb|EOY31328.1| | 16 | ||
| – | Adenylate kinase; TAIR: AT5G63400.1 adenylate kinase 1; Swiss-Prot: sp|Q08480|KAD4_ORYSJ Adenylate kinase 4; TrEMBL-Plants: tr|I3SSY8|I3SSY8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0236500 | 16 | ||
| – | Adenylate kinase; TAIR: AT5G50370.1 Adenylate kinase family protein; Swiss-Prot: sp|Q08480|KAD4_ORYSJ Adenylate kinase 4; TrEMBL-Plants: tr|I3SSY8|I3SSY8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0236500 | 16 | ||
| – | Adenylate kinase; TAIR: AT5G63400.1 adenylate kinase 1; Swiss-Prot: sp|Q08480|KAD4_ORYSJ Adenylate kinase 4; TrEMBL-Plants: tr|I3SSY8|I3SSY8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0236500 | 16 | ||
| – | Adenylate kinase; TAIR: AT5G50370.1 Adenylate kinase family protein; Swiss-Prot: sp|Q08480|KAD4_ORYSJ Adenylate kinase 4; TrEMBL-Plants: tr|I3SSY8|I3SSY8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0236500 | 16 | ||
| – | Adenylate kinase; TAIR: AT3G01820.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q8L7W7|KAD7_ARATH Probable adenylate kinase 7, mitochondrial; TrEMBL-Plants: tr|I3SZ93|I3SZ93_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0622100 | 11 | ||
| – | Adenylate kinase; TAIR: AT3G01820.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q8L7W7|KAD7_ARATH Probable adenylate kinase 7, mitochondrial; TrEMBL-Plants: tr|I3SZ93|I3SZ93_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0622100 | 11 | ||
| – | Adenylate kinase; TAIR: AT2G37250.1 adenosine kinase; Swiss-Prot: sp|Q9ZUU1|KAD1_ARATH Adenylate kinase 1, chloroplastic; TrEMBL-Plants: tr|I1NA44|I1NA44_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0694600 | 15 | ||
| – | Adenylate kinase; TAIR: AT5G26667.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|O04905|KCY3_ARATH UMP-CMP kinase 3; TrEMBL-Plants: tr|I3SIG7|I3SIG7_LOTJA UMP-CMP kinase; Found in the gene: LotjaGi3g1v0073100 | 15 | ||
| – | Adenylate kinase; TAIR: AT5G26667.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|O04905|KCY3_ARATH UMP-CMP kinase 3; TrEMBL-Plants: tr|I3SIG7|I3SIG7_LOTJA UMP-CMP kinase; Found in the gene: LotjaGi3g1v0073100 | 12 | ||
| – | Adenylate kinase; TAIR: AT5G26667.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|O04905|KCY3_ARATH UMP-CMP kinase 3; TrEMBL-Plants: tr|I3SIG7|I3SIG7_LOTJA UMP-CMP kinase; Found in the gene: LotjaGi3g1v0073100 | 12 | ||
| – | Adenylate kinase; TAIR: AT5G47840.1 adenosine monophosphate kinase; Swiss-Prot: sp|Q9FIJ7|KAD2_ARATH Adenylate kinase 2, chloroplastic; TrEMBL-Plants: tr|G7JRB1|G7JRB1_MEDTR Adenylate kinase; Found in the gene: LotjaGi3g1v0555600 | 14 | ||
| – | Adenylate kinase; TAIR: AT5G47840.1 adenosine monophosphate kinase; Swiss-Prot: sp|Q9FIJ7|KAD2_ARATH Adenylate kinase 2, chloroplastic; TrEMBL-Plants: tr|G7JRB1|G7JRB1_MEDTR Adenylate kinase; Found in the gene: LotjaGi3g1v0555600 | 14 | ||
| – | Adenylate kinase; TAIR: AT5G63400.1 adenylate kinase 1; Swiss-Prot: sp|Q08480|KAD4_ORYSJ Adenylate kinase 4; TrEMBL-Plants: tr|I3SRC9|I3SRC9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0223300 | 16 | ||
| – | Adenylate kinase; TAIR: AT5G63400.1 adenylate kinase 1; Swiss-Prot: sp|Q08480|KAD4_ORYSJ Adenylate kinase 4; TrEMBL-Plants: tr|I3SRC9|I3SRC9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0223300 | 16 | ||
| – | Adenylate kinase; TAIR: AT5G63400.1 adenylate kinase 1; Swiss-Prot: sp|Q08480|KAD4_ORYSJ Adenylate kinase 4; TrEMBL-Plants: tr|I3SRC9|I3SRC9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0223300 | 16 | ||
| – | Adenylate kinase; TAIR: AT2G37250.1 adenosine kinase; Swiss-Prot: sp|Q10S93|KAD1_ORYSJ Probable adenylate kinase 1, chloroplastic; TrEMBL-Plants: tr|I1LYZ7|I1LYZ7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0072700 | 14 | ||
| – | Adenylate kinase; TAIR: AT2G37250.1 adenosine kinase; Swiss-Prot: sp|Q10S93|KAD1_ORYSJ Probable adenylate kinase 1, chloroplastic; TrEMBL-Plants: tr|I1LYZ7|I1LYZ7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0072700 | 14 | ||
| – | Adenylate kinase; TAIR: AT5G35170.1 adenylate kinase family protein; Swiss-Prot: sp|Q8VYL1|KAD5_ARATH Adenylate kinase 5, chloroplastic; TrEMBL-Plants: tr|V7B0M9|V7B0M9_PHAVU Uncharacterized protein; Found in the gene: LotjaGi5g1v0329000 | 16 | ||
| – | Adenylate kinase; TAIR: AT5G35170.1 adenylate kinase family protein; Swiss-Prot: sp|Q8VYL1|KAD5_ARATH Adenylate kinase 5, chloroplastic; TrEMBL-Plants: tr|V7B0M9|V7B0M9_PHAVU Uncharacterized protein; Found in the gene: LotjaGi5g1v0329000 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01428 | CDD | 1 | 3.45 |