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IPR033739 is a Peptidase M10A, catalytic domain.
<p>This entry represents the matrix metalloproteinase (MMP) sub-family M10A catalytic domain. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate specification, cell migration, tissue repair, tumorigenesis, gain or loss of tissue-specific functions, and apoptosis [[cite:PUB00080248], [cite:PUB00080249], [cite:PUB00080250], [cite:PUB00080251], [cite:PUB00080252]]. In many instances, they are anchored to cell membranes via trans-membrane domains, and their activity is controlled via TIMPs (tissue inhibitors of metalloproteinases) [[cite:PUB00019054], [cite:PUB00080253], [cite:PUB00023695], [cite:PUB00080254]].</p> <p>Sequences having this domain are extracellular metalloproteases, such as collagenase and stromelysin, which degrade the extracellular matrix, are known as matrixins. They are zinc-dependent, calcium-activated proteases synthesised as inactive precursors(zymogens), which are proteolytically cleaved to yield the active enzyme [[cite:PUB00002514], [cite:PUB00001191]].</p> <p>All MMPs possess an N-terminal domain and a zinc-binding catalytic domain. The N-terminal domain peptide, cleaved during the activation step, includes a conserved PRCGVPDV octapeptide, known as the cysteine switch, whose Cys residue chelates the active site zinc atom, rendering the enzyme inactive [[cite:PUB00002456], [cite:PUB00002651]]. The catalytic domain contains a zinc ion, which is responsible for the peptide hydrolysis reaction. Another zinc ion and one to three calcium ions are present in the catalytic domain with a structural role [[cite:PUB00080268]]. All but two of the human MMPs (MMP-7 and MMP-26) also have a C-terminal hemopexin-like domain, and two MMPs (MMP-2 and MMP-9) contain fibronectin insertions into their catalytic domains [[cite:PUB00030100]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Metallopeptidase activity | Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. | ||
| Molecular function | Zinc ion binding | Interacting selectively and non-covalently with zinc (Zn) ions. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: metalloendoproteinase 1-like [Cicer arietinum] gi|502141260|ref|XP_004504503.1| | 25 | ||
| – | Matrix metalloproteinase-28 [Medicago truncatula] gi|357482059|ref|XP_003611315.1| | 13 | ||
| – | Matrix metalloproteinase-27 [Medicago truncatula] gi|357512801|ref|XP_003626689.1| | 25 | ||
| – | PREDICTED: metalloendoproteinase 1-like [Glycine max] gi|356540528|ref|XP_003538740.1| | 24 | ||
| – | PREDICTED: metalloendoproteinase 1-like [Cicer arietinum] gi|502154901|ref|XP_004509890.1| | 25 | ||
| – | Metalloendoproteinase 1; TAIR: AT1G70170.1 matrix metalloproteinase; Swiss-Prot: sp|O04529|2MMP_ARATH Metalloendoproteinase 2-MMP; TrEMBL-Plants: tr|A0A151TFV0|A0A151TFV0_CAJCA Metalloendoproteinase 1; Found in the gene: LotjaGi2g1v0313400 | 27 | ||
| – | Metalloendoproteinase 1; TAIR: AT4G16640.1 Matrixin family protein; Swiss-Prot: sp|O23507|1MMP_ARATH Metalloendoproteinase 1-MMP; TrEMBL-Plants: tr|I1LGQ7|I1LGQ7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0422500 | 25 | ||
| – | Metalloendoproteinase 1; TAIR: AT2G45040.1 Matrixin family protein; Swiss-Prot: sp|Q8GWW6|4MMP_ARATH Metalloendoproteinase 4-MMP; TrEMBL-Plants: tr|A0A151RA26|A0A151RA26_CAJCA Metalloendoproteinase 1; Found in the gene: LotjaGi3g1v0050100 | 26 | ||
| – | Matrix metalloproteinase; TAIR: AT1G70170.1 matrix metalloproteinase; Swiss-Prot: sp|O04529|2MMP_ARATH Metalloendoproteinase 2-MMP; TrEMBL-Plants: tr|V7C6E0|V7C6E0_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0142200 | 26 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd04278 | CDD | 1 | 11.11 |