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IPR006026 is a Peptidase, metallopeptidase.
This entry includes metallopeptidases associated with MEROPS peptidase families: M7, M8, M10 and M12, all of which are members of clan MA(M). <p>The majority of zinc-dependent metallopeptidases (with the notable exception of the carboxypeptidases) share a common pattern of primary structure [[cite:PUB00001563], [cite:PUB00001623]] in the part of their sequence involved in the binding of zinc, and can be grouped together as a superfamily,known as the metzincins, on the basis of this sequence similarity. They can be classified into around 40 distinct families [[cite:PUB00003579]].</p> <p>Over 70 metallopeptidase families have been identified to date. In these enzymes a divalent cation which is usually zinc, but may be cobalt, manganese or copper, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. In some families of co-catalytic metallopeptidases, two metal ions are observed in crystal structures ligated by five amino acids, with one amino acid ligating both metal ions. The known metal ligands are His, Glu, Asp or Lys. At least one other residue is required for catalysis, which may play an electrophillic role. Many metalloproteases contain an HEXXH motif, which has been shown in crystallographic studies to form part of the metal-binding site [[cite:PUB00003579]]. The HEXXH motif is relatively common, but can be more stringently defined for metalloproteases as 'abXHEbbHbc', where 'a' is most often valine or threonine and forms part of the S1' subsite in thermolysin and neprilysin, 'b' is an uncharged residue, and 'c' a hydrophobic residue. Proline is never found in this site, possibly because it would break the helical structure adopted by this motif in metalloproteases [[cite:PUB00003579]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. | ||
| Molecular function | Metallopeptidase activity | Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. | ||
| Molecular function | Zinc ion binding | Interacting selectively and non-covalently with zinc (Zn) ions. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Matrix metalloprotease [Medicago truncatula] gi|357486209|ref|XP_003613392.1| | 21 | ||
| – | Matrix metalloprotease [Medicago truncatula] gi|357486209|ref|XP_003613392.1| | 23 | ||
| – | PREDICTED: metalloendoproteinase 1-like [Cicer arietinum] gi|502141260|ref|XP_004504503.1| | 25 | ||
| – | Matrix metalloproteinase-28 [Medicago truncatula] gi|357482059|ref|XP_003611315.1| | 13 | ||
| – | Matrix metalloprotease [Medicago truncatula] gi|357486209|ref|XP_003613392.1| | 15 | ||
| – | Matrix metalloproteinase-27 [Medicago truncatula] gi|357512801|ref|XP_003626689.1| | 25 | ||
| – | Matrix metalloprotease [Medicago truncatula] gi|357486209|ref|XP_003613392.1| | 25 | ||
| – | PREDICTED: metalloendoproteinase 1-like [Glycine max] gi|356540528|ref|XP_003538740.1| | 24 | ||
| – | PREDICTED: metalloendoproteinase 1-like [Cicer arietinum] gi|502154901|ref|XP_004509890.1| | 25 | ||
| – | Metalloendoproteinase 1; TAIR: AT1G70170.1 matrix metalloproteinase; Swiss-Prot: sp|O04529|2MMP_ARATH Metalloendoproteinase 2-MMP; TrEMBL-Plants: tr|A0A151TFV0|A0A151TFV0_CAJCA Metalloendoproteinase 1; Found in the gene: LotjaGi2g1v0313400 | 27 | ||
| – | Matrix metalloproteinase; TAIR: AT1G70170.1 matrix metalloproteinase; Swiss-Prot: sp|O04529|2MMP_ARATH Metalloendoproteinase 2-MMP; TrEMBL-Plants: tr|V7CH34|V7CH34_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0313500_LC | 9 | ||
| – | Matrix metalloproteinase; TAIR: AT1G59970.1 Matrixin family protein; Swiss-Prot: sp|O04529|2MMP_ARATH Metalloendoproteinase 2-MMP; TrEMBL-Plants: tr|G7K5I7|G7K5I7_MEDTR Matrix metalloproteinase; Found in the gene: LotjaGi2g1v0313600 | 22 | ||
| – | Metalloendoproteinase 1; TAIR: AT4G16640.1 Matrixin family protein; Swiss-Prot: sp|O23507|1MMP_ARATH Metalloendoproteinase 1-MMP; TrEMBL-Plants: tr|I1LGQ7|I1LGQ7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0422500 | 25 | ||
| – | Metalloendoproteinase 1; TAIR: AT2G45040.1 Matrixin family protein; Swiss-Prot: sp|Q8GWW6|4MMP_ARATH Metalloendoproteinase 4-MMP; TrEMBL-Plants: tr|A0A151RA26|A0A151RA26_CAJCA Metalloendoproteinase 1; Found in the gene: LotjaGi3g1v0050100 | 26 | ||
| – | Matrix metalloproteinase; TAIR: AT1G70170.1 matrix metalloproteinase; Swiss-Prot: sp|O04529|2MMP_ARATH Metalloendoproteinase 2-MMP; TrEMBL-Plants: tr|V7C6E0|V7C6E0_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0142200 | 26 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd04278 | CDD | 1 | 6.67 |